FlyBase Allele Report: Dmel\nanos[ΔBX]

General Information

Symbol

Dmel\nanos^ΔBX

Species

D. melanogaster

Name

FlyBase ID

FBal0056431

Feature type

allele

Associated gene

Dmel\nanos

Associated Insertion(s)

Carried in Construct

P{nanos(ΔBX)}

Also Known As

P^{mini-nos<up>+}</up>

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Dahanukar and Wharton, 1996)

Progenitor genotype

nanos^TCE.bcdUTR

(Dahanukar and Wharton, 1996)

Carried in construct

P{nanos(ΔBX)}

Cytology

Description

Construct: Deletion of the BglII-XhoI fragment from the nos 3' UTR, leaving essentially only the TCE.

(Dahanukar and Wharton, 1996)

Allele components

Component

Use(s)

Encoded product / tool

nanos

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Dahanukar and Wharton, 1996)

Phenotype Manifest In

embryonic abdominal segment, with nanos^BN

(Yu et al., 2010)

embryonic epidermis

(Dahanukar and Wharton, 1996)

Detailed Description

Statement

Reference

nos^ΔBX, nos^BN/nos^BN females produce embryos than have a reduction in the average number of abdominal segments.

(Yu et al., 2010)

In single copy partially complements the embryonic segmentation defects of nos^-, restoring 5-6 abdominal segments, rather than 8. Two copies of P{nos(ΔBX)} can restore 8 abdominal segments, and resulting adults are viable and fertile. Cannot restore abdominal segmentation to osk^- and vas^- embryos.

(Dahanukar and Wharton, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

nanos^ΔBX, nanos^BN has embryonic abdominal segment phenotype, enhanceable by nsl1¹/wah[+]

(Yu et al., 2010)

nanos^ΔBX, nanos^BN has embryonic abdominal segment phenotype, enhanceable by nsl1⁰⁶⁵³⁶/wah[+]

(Yu et al., 2010)

nanos^ΔBX, nanos^BN has embryonic abdominal segment phenotype, enhanceable by wah[+]/nsl1^c04892

(Yu et al., 2010)

nanos^ΔBX, nanos^BN has embryonic abdominal segment phenotype, enhanceable by Df(3R)Exel8162/+

(Yu et al., 2010)

nanos^ΔBX, nanos^BN has embryonic abdominal segment | maternal effect phenotype, enhanceable | maternal effect by Hsp83^A133D/Hsp83[+]

(Song et al., 2007)

nanos^ΔBX, nanos^BN has embryonic abdominal segment | maternal effect phenotype, enhanceable | maternal effect by Hsp83^e6D/Hsp83[+]

(Song et al., 2007)

nanos^ΔBX, nanos^BN has embryonic abdominal segment | maternal effect phenotype, enhanceable | maternal effect by Hsp83[+]/Hsp83^e6A

(Song et al., 2007)

NOT Enhanced by

Statement

Reference

nanos^ΔBX, nanos^BN has embryonic abdominal segment | maternal effect phenotype, non-enhanceable by Hsp83^j5C2/Hsp83[+]

(Song et al., 2007)

NOT suppressed by

Statement

Reference

nanos^ΔBX, nanos^BN has embryonic abdominal segment | maternal effect phenotype, non-suppressible by Hsp83^j5C2/Hsp83[+]

(Song et al., 2007)

Other

Statement

Reference

nanos^ΔBX, smg^+t13.5 has embryonic abdominal segment phenotype

(Dahanukar et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

nos^ΔBX, nos^BN/nos^BN females that are also heterozygous for wah¹ give rise to embryos that rarely hatch, concomitant with a reduction in the average number of abdominal segments from 3.7 to 1.9.

nos^ΔBX, nos^BN/nos^BN females that are also heterozygous for wah⁰⁶⁵³⁶, wah^c04892 or Df(3R)Exel8162 give rise to embryos with a reduction in the average number of abdominal segments.

(Yu et al., 2010)

The mutant abdominal segmentation phenotype seen in females carrying nos^ΔBX in a nos^BN/nos^BN background is enhanced (abdominal segmentation is abolished) if the females also carry one copy of Hsp83^A133D.

The mutant abdominal segmentation phenotype seen in females carrying nos^ΔBX in a nos^BN/nos^BN background is enhanced (abdominal segmentation is reduced) if the females also carry one copy of Hsp83^e6D or Hsp83^e6A.

The mutant abdominal segmentation phenotype seen in females carrying nos^ΔBX in a nos^BN/nos^BN background is not affected if the females also carry one copy of Hsp83^j5C2.

(Song et al., 2007)

No genetic interaction in terms of abdominal segmentation is seen in the cup^unspecified/nos^ΔBX ; nos^BN combination.

(Verrotti and Wharton, 2000)

Embryos carrying nos^ΔBX in a nos^- background and carrying two copies of smg^+t13.5 develop 5 to 6 abdominal segments. Embryos carrying nos^ΔBX in a nos^- background and carrying two copies of smg^+t13.5 develop 2 abdominal segments.

(Dahanukar et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

wah^+t9.9 rescues the reduced abdominal segments phenotype seen in embryos produced by nos^ΔBX, nos^BN/nos^BN females that are also heterozygous for wah¹.

(Yu et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

nanos^ΔBX

nos^ΔBX

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close