FB2024_03 , released June 25, 2024
Allele: Dmel\UbxCbx-1RM
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General Information
Symbol
Dmel\UbxCbx-1RM
Species
D. melanogaster
Name
Contrabithorax 1 revertant of Madrid
FlyBase ID
FBal0049241
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
Carried in Construct
Also Known As
Cbx1RM
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Gonzalez-Gaitan et al., 1990)
Progenitor genotype
UbxCbx-1
(Gonzalez-Gaitan et al., 1990, Micol and Garcia-Bellido, 1988)
Cytology

Polytene chromosomes normal.

(Gonzalez-Gaitan et al., 1990)
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      UbxCbx-1RM/Ubxlac1 transheterozygotes die before the third larval stage, unless rescued by Dp(3;1)P115.

      (Casares et al., 1997)

      The mesothorax phenotype is reduced in combination with RpII215Ubl or RpS174. The dominant wing phenotype is 99% penetrant, occurring in the posterior compartment and variably in the anterior compartment. UbxCbx-1RM heterozygotes also carrying a Ubx loss of function allele show transformation of T3 towards T2, and A1a towards T3a.

      (Gonzalez-Gaitan et al., 1990)

      UbxCbx-1RM/+ flies show a mesothoracic phenotype slightly weaker than for UbxCbx-1/+ Phenotype shows transvection effects. Rearrangements at/near Ubx reduce the UbxCbx-1RM phenotype. UbxCbx-2/UbxCbx-1RM flies show the phenotype expected from transvection - weak effects on wing and alula plus low penetrance UbxCbx-2 transformation phenotype.

      (Micol and Garcia-Bellido, 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      UbxCbx-1RM has visible | dominant | homeotic phenotype, suppressible by za693

      (Micol and Garcia-Bellido, 1988)

      UbxCbx-1RM has visible | dominant | homeotic phenotype, suppressible by za692

      (Micol and Garcia-Bellido, 1988)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      UbxCbx-1RM has adult mesothoracic segment phenotype, suppressible by za692

      (Micol and Garcia-Bellido, 1988)

      UbxCbx-1RM has adult mesothoracic segment phenotype, suppressible by za693

      (Micol and Garcia-Bellido, 1988)

      UbxCbx-1RM has haltere | ectopic phenotype, suppressible by za692

      (Micol and Garcia-Bellido, 1988)

      UbxCbx-1RM has haltere | ectopic phenotype, suppressible by za693

      (Micol and Garcia-Bellido, 1988)

      UbxCbx-1RM has wing phenotype, suppressible by za692

      (Micol and Garcia-Bellido, 1988)

      UbxCbx-1RM has wing phenotype, suppressible by za693

      (Micol and Garcia-Bellido, 1988)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      UbxCbx-1RM/Ubxlac1 transheterozygotes can be rescued by Dp(3;1)P115.

      (Casares et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The Cbx mesothorax phenotype is reduced in a number of Cbx mutations in combination with RpII215Ubl. This reduction of the Cbx phenotype follows the order: UbxCbx-Hm > UbxCbx-2RM = UbxCbx-2 = UbxCbx-M1 > UbxCbx-1RM = UbxCbx-1 = UbxCbx-3 = UbxCbx-Twt. The Cbx mesothorax phenotype is reduced in a number of Cbx mutations in combination with RpS174. This reduction of the Cbx phenotype follows the order: UbxCbx-2RM > UbxCbx-2 = UbxCbx-M1 > UbxCbx-1 = UbxCbx-1RM.

      (Gonzalez-Gaitan et al., 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Cbx1RM
      (Duncan, 2002, Casares et al., 1997, Gonzalez-Gaitan et al., 1990, Micol and Garcia-Bellido, 1988)
      UbxCbx-1RM
      Name Synonyms
      Contrabithorax 1 revertant of Madrid
      (Micol and Garcia-Bellido, 1988)
      Secondary FlyBase IDs
        References (4)