FlyBase Allele Report: Dmel\Ubx[Cbx-2]

General Information

Symbol

Dmel\Ubx^Cbx-2

Species

D. melanogaster

Name

FlyBase ID

FBal0017564

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

Carried in Construct

Also Known As

Cbx²

Key Links

Allele class

neomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

neomorphic allele - genetic evidence

(Botas et al., 1988)

Mutagen

Progenitor genotype

Caused by aberration

In(3R)Cbx²

Cytology

Description

Breakpoint in the upstream region of Ubx.

(Botas et al., 1988)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Dura et al., 1985)

visible | dominant

(Gonzalez-Gaitan et al., 1990, Botas et al., 1988)

visible | dominant | homeotic

(Micol and Garcia-Bellido, 1988)

visible | recessive

(Bender et al., 1985)

Phenotype Manifest In

abdominal 1 ventral denticle belt | embryonic stage

(Bender et al., 1985)

adult mesothoracic segment

(Micol and Garcia-Bellido, 1988)

alula (with Ubx^Cbx-1RM)

(Micol and Garcia-Bellido, 1988)

haltere | ectopic

(Micol and Garcia-Bellido, 1988)

wing

(Gonzalez-Gaitan et al., 1990, Micol and Garcia-Bellido, 1988)

wing (with Ubx^Cbx-1RM)

(Micol and Garcia-Bellido, 1988)

Detailed Description

Statement

Reference

The mesothorax phenotype is reduced in combination with RpII215^Ubl or RpS17⁴. The dominant wing phenotype is 100% penetrant, occurring in the posterior compartment and variably in the anterior compartment. Ubx^Cbx-2/Ubx¹⁹⁵ transheterozygotes show transformation of T3 towards T2, and A1a towards T3a.

(Gonzalez-Gaitan et al., 1990)

Phenotype is partially penetrant in heterozygotes, and shows erratic specificity.

(Botas et al., 1988)

The Ubx^Cbx-2 mesothoracic phenotype varies in expressivity and penetrance. Phenotype shows transvection effects. Rearrangements at/near Ubx enhance the Ubx^Cbx-2 phenotype. Ubx^Cbx-2/Ubx^Cbx-1RM flies show the phenotype expected from transvection - weak effects on wing and alula plus low penetrance Ubx^Cbx-2 transformation phenotype.

(Micol and Garcia-Bellido, 1988)

Hemizygotes display ventral setal belt on the first abdominal segment is intermediate between the normal third thoracic belt and the normal first abdominal belts.

(Bender et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ubx^Cbx-2 has visible | dominant | homeotic phenotype, enhanceable by z^a693

(Micol and Garcia-Bellido, 1988)

Ubx^Cbx-2 has visible | dominant | homeotic phenotype, enhanceable by z^a692

(Micol and Garcia-Bellido, 1988)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ubx^Cbx-2 has adult mesothoracic segment phenotype, enhanceable by z^a693

(Micol and Garcia-Bellido, 1988)

Ubx^Cbx-2 has haltere | ectopic phenotype, enhanceable by z^a693

(Micol and Garcia-Bellido, 1988)

Ubx^Cbx-2 has wing phenotype, enhanceable by z^a693

(Micol and Garcia-Bellido, 1988)

Ubx^Cbx-2 has adult mesothoracic segment phenotype, enhanceable by z^a692

(Micol and Garcia-Bellido, 1988)

Ubx^Cbx-2 has haltere | ectopic phenotype, enhanceable by z^a692

(Micol and Garcia-Bellido, 1988)

Ubx^Cbx-2 has wing phenotype, enhanceable by z^a692

(Micol and Garcia-Bellido, 1988)

Other

Statement

Reference

Ubx^Cbx-2, ph-d² has wing phenotype

(Dura et al., 1985)

Ubx^Cbx-2, ph-d² has scutum phenotype

(Dura et al., 1985)

Additional Comments

Genetic Interactions

Statement

Reference

Semi-lethal in combination with ph-d². Escapers show complete transformation of wing to haltere and a marked reduction of the mesonotum.

(Dura et al., 1985)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Kreber.

(Lindsley and Zimm, 1992)

Comments

The Cbx mesothorax phenotype is reduced in a number of Cbx mutations in combination with RpII215^Ubl. This reduction of the Cbx phenotype follows the order: Ubx^Cbx-Hm > Ubx^Cbx-2RM = Ubx^Cbx-2 = Ubx^Cbx-M1 > Ubx^Cbx-1RM = Ubx^Cbx-1 = Ubx^Cbx-3 = Ubx^Cbx-Twt. The Cbx mesothorax phenotype is reduced in a number of Cbx mutations in combination with RpS17⁴. This reduction of the Cbx phenotype follows the order: Ubx^Cbx-2RM > Ubx^Cbx-2 = Ubx^Cbx-M1 > Ubx^Cbx-1 = Ubx^Cbx-1RM.

(Gonzalez-Gaitan et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cbx²

(Duncan, 2002, Gonzalez-Gaitan et al., 1990, Botas et al., 1988, Micol and Garcia-Bellido, 1988, Lipshitz et al., 1987, Bender et al., 1985, Dura et al., 1985, Bender et al., 1983)

Ubx^Cbx-2

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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