FB2024_03 , released June 25, 2024
Allele: Dmel\14-3-3εS-1259
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General Information
Symbol
Dmel\14-3-3εS-1259
Species
D. melanogaster
Name
FlyBase ID
FBal0048993
Feature type
allele
Associated gene
Dmel\14-3-3ε
Associated Insertion(s)
Carried in Construct
Also Known As
14-3-3εF199Y
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Chang and Rubin, 1997, Karim et al., 1996)
Progenitor genotype
Cytology
Description

Amino acid replacement: F199Y.

(Chang and Rubin, 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:18,248,032..18,248,032 [+]
Nucleotide change:

T18248032A

Amino acid change:

F199Y | 14-3-3epsilon-PA; F199Y | 14-3-3epsilon-PB; F199Y | 14-3-3epsilon-PC; F199Y | 14-3-3epsilon-PD

Reported amino acid change:

F199Y

(Chang and Rubin, 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes have no detectable phenotype in a wild-type background.

      (Chang and Rubin, 1997)

      Homozygotes are subviable.

      (Karim et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      14-3-3εS-1259, Raf12 has lethal | dominant phenotype

      (Chang and Rubin, 1997)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      14-3-3epsilon[+]/14-3-3εS-1259 is a suppressor of eye phenotype of Ras85DV12.sev

      (Chang and Rubin, 1997)

      14-3-3εS-1259 is a suppressor of phenotype of Ras85DV12.sev

      (Karim et al., 1996)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Many 14-3-3ζP1188 germ-line clones in 14-3-3εS-1259/+ females have defects in oocyte specification.

      (Benton et al., 2002)

      Suppresses the rough eye phenotype of Ras85DV12.sev.

      (Karim et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      14-3-3εF199Y
      (Benton et al., 2002, Chang and Rubin, 1997)
      14-3-3εS-1259
      SR3-91259
      (Chang and Rubin, 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)