FlyBase Allele Report: Dmel\gcm[rA87]

(Cattenoz et al., 2016, Kammerer and Giangrande, 2001, Granderath et al., 2000, Jones, 1999.11.22, Vincent et al., 1996, Jones et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of infertility

CEA with gcm^rA87.P

(Cattenoz et al., 2016)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Pereanu et al., 2007)

decreased cell number | adult stage (with gcm^rA87.P)

(Cattenoz et al., 2016)

decreased fecundity | female (with gcm^rA87.P)

(Cattenoz et al., 2016)

female semi-sterile (with gcm^rA87.P)

(Cattenoz et al., 2016)

lethal (with Df(2L)30A-C)

(Kahsai and Cook, 2018)

lethal (with Df(2L)N22-3)

(Kahsai and Cook, 2018)

lethal (with Df(2L)N22-5)

(Kahsai and Cook, 2018)

lethal - all die during embryonic stage

(Pereanu et al., 2007)

some die during embryonic stage

(Pereanu et al., 2007)

viable

(Vincent et al., 1996, Jones et al., 1995)

Phenotype Manifest In

embryonic/larval ganglionic tracheal branch

(Pereanu et al., 2007)

embryonic/larval plasmatocyte

(Pereanu et al., 2007)

glial cell

(Pereanu et al., 2007)

sense organ & wing

(Vincent et al., 1996)

sense organ | ectopic

(Vincent et al., 1996)

spermatheca (with gcm^rA87.P)

(Cattenoz et al., 2016)

wing margin

(Vincent et al., 1996)

Detailed Description

Statement

Reference

gcm^rA87.P/gcm^rA87 transheterozygous females present a significant reduction in the numbers of eggs laid and progeny, but the corresponding males present no defects in the number of progeny, as compared to controls; most of the female's spermathecae exhibit a complete loss of secretory cells, although some remain in a few cases.

(Cattenoz et al., 2016)

Loss of gcm in gcm^rA87 mutants results in embryonic lethality accompanied by the almost complete absence of glial cells and reduction in macrophages.

The total loss of glia in gcm^rA87 mutant embryos causes neuronal pathfinding defects in stage 16 embryos. The cerebral trachea grows towards the dorsomedial surface of the neuropile normally. However, upon reaching the neuropile surface, it gives off numerous thick, long branches that are never observed in wild-type embryos.

(Pereanu et al., 2007)

Homozygotes exhibit an abnormal and variable number of ectopic sensory organs in the region of the twin sensillum on the wing margin (TSM).

(Vincent et al., 1996)

Transheterozygotes with gcm^- alleles are viable.

(Jones et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

gcm^rA87/gcm[+] is a non-enhancer of indirect flight muscle cell phenotype of Dys^RNAi.NH2.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2011)

gcm^rA87/gcm[+] is a non-enhancer of indirect flight muscle cell phenotype of Dg^RNAi.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

gcm Dys double heterozygous flies (gcm^rA87/Df(3R)Exel6184) do not exhibit indirect flight muscle degeneration.

One copy of gcm^rA87 does not enhance the indirect flight muscle degeneration seen when Dys^{dsRNA.NH2.Scer\UAS} is expressed under the control of Scer\GAL4^Act.PU.

One copy of gcm^rA87 does not enhance the indirect flight muscle degeneration seen when Dg^{dsRNA.Scer\UAS} is expressed under the control of Scer\GAL4^tub.PU.

gcm^rA87 Dg³²³ double heterozygous flies do not exhibit indirect flight muscle degeneration.

(Kucherenko et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5445

P{PZ}gcm^rA87/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

Comments

Lethal excision lines have been generated by Δ2-3 mediated P-element excision, gcm²⁶ and gcm³⁴.

(Vincent et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

gcm^RA87

(Shen et al., 2018)

gcm^rA87

(Kahsai and Cook, 2018, Cattenoz et al., 2016, Kucherenko et al., 2011, Pereanu et al., 2007)

gcm^ra87

(Mandalaywala et al., 2008)

glide/gcm^rA87

(van de Bor et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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