FlyBase Allele Report: Dmel\raw[02418]

General Information

Symbol

Dmel\raw⁰²⁴¹⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0044467

Feature type

allele

Associated gene

Dmel\raw

Associated Insertion(s)

P{PZ}raw⁰²⁴¹⁸

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Byars et al., 1999)

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}raw⁰²⁴¹⁸

Cytology

Description

P{PZ} insertion in an intron.

(Byars et al., 1999)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(BDGP Project Members, 1994-1999)

lethal - all die during embryonic stage | recessive

(Byars et al., 1999)

some die during embryonic stage | recessive

(Byars et al., 1999)

Phenotype Manifest In

embryo | dorsal closure stage

(Byars et al., 1999)

embryonic/first instar larval cuticle | dorsal

(Byars et al., 1999)

embryonic/first instar larval cuticle | ventral

(Byars et al., 1999)

presumptive embryonic/larval peripheral nervous system

(Byars et al., 1999)

Detailed Description

Statement

Reference

Homozygous embryos have defects in dorsal closure and ventral cuticle differentiation. The dorsal cuticle is reduced and the embryos have upturned tails and curved abdomens. Elongated neuronal cell bodies, thickened axon bundles and fasciculation defects are seen in the peripheral nervous system. The cells in the amnioserosa are not apoptotic in stage 8-14 embryos. Elongated leading edge cells are seen in homozygous embryos undergoing dorsal closure.

(Byars et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

raw⁰²⁴¹⁸/raw[+] is a suppressor | partially of partially lethal - majority die phenotype of slpr^BS06

(Polaski et al., 2006)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

raw⁰⁶⁸²⁵

(BDGP Project Members, 1994-1999)

Fails to complement

raw²

(Byars et al., 1999)

raw¹

(Byars et al., 1999)

raw^k01021

(Byars et al., 1999)

raw^k03514

(Byars et al., 1999)

raw^k01021

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

A. Spradling.

Comments

Excision of the P{PZ} element reverts the lethal phenotype.

(Byars et al., 1999)

Fails to complement: wg⁰³³²⁴.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

l(2)02418

(Byars et al., 1999)

l(2)06825⁰²⁴¹⁸

(BDGP Project Members, 1994-1999)

raw⁰²⁴¹⁸

(Polaski et al., 2006)

raw²⁴¹⁸

(Byars et al., 1999)

raw^P2418

(Polaski et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close