FB2024_03 , released June 25, 2024
Allele: Dmel\otu104
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General Information
Symbol
Dmel\otu104
Species
D. melanogaster
Name
FlyBase ID
FBal0044234
Feature type
allele
Associated gene
Dmel\otu
Associated Insertion(s)
Carried in Construct
P{otu-104}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Sass et al., 1995)
Progenitor genotype
otu+t5.4
(Sass et al., 1995)
Carried in construct
P{otu-104}
Cytology
Description

AccI genomic fragment of otu containing the alternatively spliced exon 6a is replaced with the corresponding fragment from cDNA that lacks exon 6a.

(Sass et al., 1995)
Allele components
Component
Use(s)
Regulatory region(s)
otu
Encoded product / tool
otu
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      otu104 is a suppressor of visible | germline clone | egg stage phenotype of glo162x

      (Kalifa et al., 2009)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      otu104 is a suppressor of dorsal appendage | germline clone phenotype of glo162x

      (Kalifa et al., 2009)

      otu104 is a suppressor | partially of nurse cell | germline clone phenotype of glo162x

      (Kalifa et al., 2009)

      otu104 is a suppressor | partially of nurse cell & nuclear chromosome phenotype of Hrb27C377/Hrb27C02647

      (Goodrich et al., 2004)

      otu104 is a suppressor of nurse cell & nuclear chromosome phenotype of sqd1

      (Goodrich et al., 2004)

      otu104 is a suppressor of karyosome phenotype of hfp9

      (Van Buskirk and Schupbach, 2002)

      otu104 is a suppressor of nurse cell & nuclear chromosome phenotype of hfp9

      (Van Buskirk and Schupbach, 2002)

      otu104 is a suppressor of egg chamber phenotype of hfp9

      (Van Buskirk and Schupbach, 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Multiple copies of the otu104 transgene facilitate further development of poly2 homozygous ovaries.

      (Klusza and Deng, 2010)

      A single copy of otu104 completely eliminates the dorsal appendage defects of late oocytes dissected from glo162x ovaries and reduces the nurse cell chromatin defect from 88% to 56% of egg chambers.

      (Kalifa et al., 2009)

      otu104 suppresses the penetrance of the chromosome morphology phenotype of sqd1 homozygous nurse cells from 98% to 17%.

      (Goodrich et al., 2004)

      otu104 rescues the nurse cell and oocyte nuclear morphology and germline division defects of pUf689 mutant females.

      (Van Buskirk and Schupbach, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      otu104 rescues otu[+]/otu13

      (Klusza et al., 2013)
      Comments

      Expression of otu104 rescues the nurse cell chromatin dispersal failure seen in otu13/+ mutant females.

      (Klusza et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Encodes the otu 104kD isoform. Capable of restoring fertility to all otu mutants. Morphological analysis of otu10 P{otu-98} ovaries reveals the construct restores wild type ovarian morphology.

      (Sass et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      otu104
      Name Synonyms
      Secondary FlyBase IDs
        References (6)