FlyBase Allele Report: Dmel\fru[0-1]

General Information

Symbol

Dmel\fru^0-1

Species

D. melanogaster

Name

FlyBase ID

FBal0043077

Feature type

allele

Associated gene

Dmel\fru

Associated Insertion(s)

P{wA^R}fru^0-1

Carried in Construct

Also Known As

fru²

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Moses et al., 1989)

Progenitor genotype

Associated Insertion(s)

P{wA^R}fru^0-1

Cytology

Description

Insertion between the 5' exons of the P3 and P4 promoters.

(Anand et al., 2001)

Insertion lies between the P1 promoter and the common coding region.

(Goodwin et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal copulation | male (with fru^NP0021)

(Sato et al., 2020)

abnormal courtship behavior | male

(Villella et al., 1997)

abnormal courtship behavior | male (with Df(3R)fru^w24)

(Anand et al., 2001)

abnormal courtship behavior | male (with fru^4-40)

(Anand et al., 2001)

abnormal courtship behavior | male (with fru^NP0021)

(Sato et al., 2020)

abnormal courtship behavior | male (with fru^w9)

(Anand et al., 2001)

abnormal courtship behavior | male (with fru^w12)

(Anand et al., 2001)

abnormal courtship behavior | male (with fru^w27)

(Anand et al., 2001)

abnormal courtship behavior | male | recessive

(Gailey and Hall, 1989)

abnormal mating

(Lee et al., 2001)

abnormal mating (with fru¹)

(Lee et al., 2001)

abnormal neuroanatomy | adult stage | male (with fru^sat)

(Sato et al., 2020)

fertile

(Lee and Hall, 2001)

male fertile

(Anand et al., 2001)

male fertile (with fru¹)

(Anand et al., 2001)

male fertile (with fru^M5)

(Anand et al., 2001)

male semi-sterile (with fru³)

(Anand et al., 2001)

male semi-sterile (with fru^4-40)

(Anand et al., 2001)

male semi-sterile (with fru⁴)

(Anand et al., 2001)

male semi-sterile (with fru^sat15)

(Anand et al., 2001)

male sterile (with Df(3R)fru^w24)

(Anand et al., 2001)

male sterile (with fru^w9)

(Anand et al., 2001)

male sterile (with fru^w12)

(Anand et al., 2001)

male sterile (with fru^w27)

(Anand et al., 2001)

viable

(Lee and Hall, 2001, Goodwin et al., 2000)

Phenotype Manifest In

muscle cell of male abdominal 5 muscle

(Anand et al., 2001, Taylor and Knittel, 1995)

muscle cell of male abdominal 5 muscle (with Df(3R)fru^w24)

(Anand et al., 2001)

muscle cell of male abdominal 5 muscle (with fru^w9)

(Anand et al., 2001)

muscle cell of male abdominal 5 muscle (with fru^w12)

(Anand et al., 2001)

muscle cell of male abdominal 5 muscle (with fru^w27)

(Anand et al., 2001)

Detailed Description

Statement

Reference

fru^0-1/fru^sat males exhibit reduced midline crossing of ppk23- expressing axons.

fru^0-1/fru^NP0021 males exhibit reduced courtship activity and copulation success.

(Sato et al., 2020)

Only 10% of the expected number of fru^0-1/Df(3R)fru^w24 adults are found compared to control siblings. 7% of fru^0-1/fru^w9 males are fertile. 24% of fru^0-1/fru^4-40 males are fertile. 33% of fru^0-1/fru^sat15 males are fertile (this may reflect genetic background effects). 93% of fru^0-1/fru^M5 males are fertile. 23% of fru^0-1/fru³ males are fertile. 25% of fru^0-1/fru⁴ males are fertile. Male-female courtship as measured by wing extension index (WEI) is almost completely abolished in fru^0-1/fru^w9, fru^0-1/fru^w12, fru^0-1/Df(3R)fru^w24 or fru^0-1/fru^w27 males. fru^0-1/fru^w9, fru^0-1/fru^w12 or fru^0-1/fru^4-40 males show substantial chaining. Homozygotes develop a nearly wild-type muscle of Lawrence.

(Anand et al., 2001)

The numbers of serotonergic-abdominal ganglion neurons and their projections in mutant adult males appear normal or nearly so (in terms of 5-HT expression).

(Lee and Hall, 2001)

fru^0-1/fru^0-1 and fru^0-1/fru¹ males show longer than normal mating-initiation latencies compared to heterozygous controls when mated to a single virgin wild-type female. The mating duration is not significantly different from wild type.

The density of varicosities of the sAbg neurons which are associated with the reproductive organs is nearly normal in fru^0-1 males.

(Lee et al., 2001)

Males are more stimulated to court females than fru³ or fru⁴. All males that exhibit any courtship do exhibit tapping behaviour (tapping of the female with the forelegs). Males, when presented with both sexes simultaneously, will show a courtship bias toward females. Mutant females are courted by wild-type males at normal levels.

(Villella et al., 1997)

A normal size muscle of Lawrence (MOL) often forms in homozygous males. There are slightly more adult muscle nuclei in MOL-position fibres than medial fibres, but these fibres still have significantly fewer nuclei than wild-type male MOL fibres. The number of myoblasts in unaffected.

(Taylor and Knittel, 1995)

Homozygous males form courtship chains and behaviourally sterile: failure to curl abdomen in attempted copulation. Some males are fertile and have no 'muscle of Lawrence' (MOL) at all or have an intermediate MOL phenotype: slight thickening or slightly altered insertion sites of the longitudinal muscles. Male heterozygotes with In(3R)fru formed courtship chains but were fully fertile and had an abnormal MOL.

(Gailey et al., 1991)

Homozygous males appear normal in size and mobility. Homozygous males show chain behaviour and show incomplete penetrance of fru-like sterility. Heterozygotes never form courtship chains and are fully fertile. fru¹/fru^0-1 males show chain behaviour, although not as intensely as either fru¹ or fru^0-1 homozygotes, but are essentially normal in fertility.

(Gailey and Hall, 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fru^sat/fru^0-1 has abnormal neuroanatomy | adult stage | male phenotype, enhanceable by tei^EY11779/Scer\GAL4^Poxn.PU

(Sato et al., 2020)

fru^NP0021/fru^0-1 has abnormal courtship behavior | male phenotype, enhanceable by tei^EY11779/Scer\GAL4^NP0021

(Sato et al., 2020)

fru^NP0021/fru^0-1 has abnormal copulation | male phenotype, enhanceable by tei^EY11779/Scer\GAL4^NP0021

(Sato et al., 2020)

Suppressed by

Statement

Reference

fru^sat/fru^0-1 has abnormal neuroanatomy | male | adult stage phenotype, suppressible | partially by Scer\GAL4^Poxn.PU/tei^RNAi.ex4.UAS

(Sato et al., 2020)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

ARO-1

(Gailey and Hall, 1989)

fru2

(Davis and Ito, 2001)

fru^0-1

fru²

(Sato et al., 2020, Sato et al., 2019, Chowdhury et al., 2017, Ito et al., 2012, Song et al., 2002, Anand et al., 2001, Baker et al., 2001, Lee and Hall, 2001, Lee et al., 2001, Goodwin et al., 2000, Greenspan and Ferveur, 2000, Ryner et al., 1996, Taylor and Knittel, 1995, Gailey et al., 1991)

fru^ARO-1

Name Synonyms

Secondary FlyBase IDs

FBal0031284

References (23)

Report Sections

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