FlyBase Allele Report: Dmel\InR[353]

General Information

Symbol

Dmel\InR³⁵³

Species

D. melanogaster

Name

FlyBase ID

FBal0042641

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

Also Known As

dinr³⁵³

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Fernandez et al., 1995)

Mutagen

ethyl methanesulfonate

(Fernandez et al., 1995)

Progenitor genotype

Cytology

Description

Amino acid replacement: R1419C.

(Brogiolo et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:21,575,427..21,575,427 [-]

Nucleotide change:

C21575427T

Amino acid change:

R1467C | InR-PA; R1467C | InR-PB; R1467C | InR-PC; R1467C | InR-PD

Reported amino acid change:

R1419C

Comment:

Mutation affects an active site residue, which mediates insulin receptor kinase substrate specificity.

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

(Brogiolo et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with InR²⁷³)

(Song et al., 2003)

abnormal neuroanatomy | adult stage | somatic clone

(Luo et al., 2020)

abnormal neuroanatomy | somatic clone

(Song et al., 2003)

lethal (with InR⁰⁵⁵⁴⁵)

(Gao and Pan, 2001)

lethal - all die during embryonic stage | recessive

(Fernandez et al., 1995)

some die during embryonic stage | recessive

(Fernandez et al., 1995)

Phenotype Manifest In

dendrite | adult stage | somatic clone

(Luo et al., 2020)

distal medullary amacrine neuron Dm8 | adult stage | somatic clone

(Luo et al., 2020)

egg chamber | germline clone

(LaFever and Drummond-Barbosa, 2005)

embryonic/larval optic lobe | somatic clone

(Song et al., 2003)

female germline stem cell | germline clone

(LaFever and Drummond-Barbosa, 2005)

germline cyst | germline clone

(LaFever and Drummond-Barbosa, 2005)

lamina anlage (with InR²⁷³)

(Song et al., 2003)

medulla anlage

(Song et al., 2003)

medulla anlage (with InR²⁷³)

(Song et al., 2003)

photoreceptor cell & axon (with InR²⁷³)

(Song et al., 2003)

Detailed Description

Statement

Reference

64% of homozygous female germline cysts are developmentally delayed. Mutant germline stem cells (GSCs) have a reduced division rate compared to wild-type GSCs. 1 in 6 egg chambers in mosaic ovarioles in which the entire germline is homozygous fail to progress through vitellogenesis.

(LaFever and Drummond-Barbosa, 2005)

InR³⁵³ mutants show no defects in opsin regulation.

(Mikeladze-Dvali et al., 2005)

In mosaic larvae in which homozygous clones have been induced in the eye, photoreceptor cell axons project normally through the optic stalk but fail to target the optic lobe properly. Mutant photoreceptor cell growth cones fail to expand at their termination points in the medulla. Surviving InR²⁷³/InR³⁵³ third instar larvae have guidance defects in the photoreceptor cell axons; gaps in the lamina, crossing of axons and failure of growth cone expansion in the medulla are seen.

(Song et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

InR⁰⁵⁵⁴⁵/InR³⁵³ has lethal phenotype, suppressible by Tsc1²⁹

(Gao and Pan, 2001)

Other

Statement

Reference

InR⁰⁵⁵⁴⁵/InR³⁵³, Tsc1²⁹ has partially lethal - majority live phenotype

(Gao and Pan, 2001)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Tsc1²⁹ suppresses the lethality of InR³⁵³/InR⁰⁵⁵⁴⁵ animals, allowing 39% animals to survive to adults.

(Gao and Pan, 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

91548

ru¹ Diap1^th-1 st¹ kni^ri-1 rn^roe-1 p^p e^s InR³⁵³ ca¹/TM3, P{ftz-lacZ.ry⁺}TM3, Sb¹ ry^*

Notes on Origin

Discoverer

Comments

Alleles of InR form an allelic series based on phenotypic strength: InR³³⁹ > InR³¹ > InR²¹¹ > InR^E19 > InR³⁵³.

(Brogiolo et al., 2001)

When in trans with Df(3R)e-D7 the lethal phenotype can be rescue by P{hs-inr}.

(Fernandez et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DInR³⁵³

(Mikeladze-Dvali et al., 2005)

InR³⁵³

(Yamamoto et al., 2021, Luo et al., 2020, Kang et al., 2018, Kapuria et al., 2012, Biteau et al., 2010)

dinr³⁵³

(LaFever and Drummond-Barbosa, 2005, Song et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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