FlyBase Allele Report: Dmel\pho[cv]

General Information

Symbol

Dmel\pho^cv

Species

D. melanogaster

Name

FlyBase ID

FBal0039759

Feature type

allele

Associated gene

Dmel\pho

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

pho^c

(Brown et al., 1998)

Cytology

Description

As for pho^c : 7.5kb gypsy insertion within an 86bp intron in the 5' non-coding region of the transcript. Presumably a second lesion has occurred, and is responsible for the altered behavior of pho^cv.

(Brown et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Brown et al., 1998)

lethal - all die during embryonic stage | maternal effect | recessive

(Girton and Jeon, 1994)

some die during embryonic stage | recessive | maternal effect | recessive

(Girton and Jeon, 1994)

viable

(Brown et al., 1998)

Phenotype Manifest In

adult abdominal segment 4 | maternal effect

(Girton and Jeon, 1994)

antenna (with pho¹)

(Atchison et al., 2003)

embryonic abdominal segment 6 | maternal effect

(Girton and Jeon, 1994)

embryonic abdominal segment 7 | maternal effect

(Girton and Jeon, 1994)

embryonic abdominal segment 8 | ectopic | maternal effect

(Choi et al., 2000)

embryonic abdominal segment | maternal effect

(Choi et al., 2000)

embryonic head | maternal effect

(Girton and Jeon, 1994)

embryonic thoracic segment | maternal effect

(Choi et al., 2000)

embryonic thorax | maternal effect

(Girton and Jeon, 1994)

presumptive embryonic/larval central nervous system | maternal effect

(Girton and Jeon, 1994)

presumptive embryonic/larval peripheral nervous system | maternal effect

(Girton and Jeon, 1994)

sex comb (with pho¹)

(Atchison et al., 2003)

unguis (with pho¹)

(Atchison et al., 2003)

Detailed Description

Statement

Reference

Maternal effect pho^cv/pho^cv embryos raised at the restrictive temperature of 25[o]C show transformation of the denticle belts of thoracic segments to the first abdominal segments and the posterior abdominal segments to the eighth segment.

(Choi et al., 2000)

Embryos display incomplete head involution with the appearance of extra copies of anterior structures. Homeotic transformation of the thoracic segments to a more posterior identity, but not beyond the first abdominal segment. Homeotic transformation of abdominal segments 6 and 7 to the identity of the eighth. Strong effect on the overall organisation and development of the CNS and PNS. A small fraction survive to larval hatching and adulthood. Some males have small darkly pigmented patches of cuticle in the fourth abdominal segment, a partial transformation of the fourth segment to a more posterior segment.

(Girton and Jeon, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ecol\lacZ^abd-A.1.7, pho^cv has visible phenotype

(Shimell et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

pho^cv/pho¹ has sex comb phenotype, suppressible by Hsap\YY1^G4DBD.Hsp70

(Atchison et al., 2003)

pho^cv/pho¹ has unguis phenotype, suppressible | partially by Hsap\YY1^G4DBD.Hsp70

(Atchison et al., 2003)

pho^cv/pho¹ has antenna phenotype, suppressible by Hsap\YY1^G4DBD.Hsp70

(Atchison et al., 2003)

NOT suppressed by

Statement

Reference

pho^cv/pho¹ has antenna phenotype, non-suppressible by Hsap\YY1^arm.PA

(Atchison et al., 2003)

pho^cv/pho¹ has sex comb phenotype, non-suppressible by Hsap\YY1^arm.PA

(Atchison et al., 2003)

pho^cv/pho¹ has unguis phenotype, non-suppressible by Hsap\YY1^arm.PA

(Atchison et al., 2003)

Suppressor of

Statement

Reference

pho^cv is a suppressor of phenotype of w^iab-2(1.7)

(Shimell et al., 2000)

Other

Statement

Reference

Ecol\lacZ^abd-A.1.7, pho^cv has pigment cell phenotype

(Shimell et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

pho¹/pho^cv suppresses the pairing-dependent silencing of w^iab-7PRE.860 seen in flies homozygous for P{iab-7PRE-w.860}P24.

(Mishra et al., 2001)

The addition of homozygous pho^cv reduces the pairing sensitive suppression of w gene expression seen in homozygous w^iab-2(1.7) flies.

(Shimell et al., 2000)

The addition of pho¹/pho^cv strongly suppresses the Pairing sensitive silencing effect seen in w^Mcp.10, w^Mcp.13,w^{Mcp.scs'.12:15} and w^Mcp.scs'.11. the addition of pho¹/pho^cv has no effect on the Pairing sensitive silencing effect seen in w^Mcp.11, and w^Mcp.scs'.14. The addition pho¹/pho^cv very strongly suppresses the Pairing sensitive silencing effect seen in the w^Mcp.scs'.14/ w^Mcp.13 (P{Mcp-w#14}AP-2^stummelbein/+, P{Mcp-w#13}116/+) double heterozygous insertion.

(Muller et al., 1999)

Eye colour encoded by w^en.8 is darker in pho¹/pho¹ or pho¹/pho^cv background.

(Brown et al., 1998)

Xenogenetic Interactions

Statement

Reference

When heatshocked twice daily, Hsap\YY1^{Hsp70.T:Scer\GAL4} nearly completely corrects the antennal and sex comb defects in pho¹/pho^cv mutant flies. Segmentation is largely normal, although pigmentation on tergite 5 is not always complete. Correction of claw structures is variable ranging from complete to partial correction.

(Atchison et al., 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Homozygotes die before pharate adult stage and hemizygotes survive with a weak pho phenotype. This suggests lethality could be due to a second site lethal. Recombinants were isolated, one gave a homozygous viable pho phenotype, the pho allele is referred to as pho^cv, it is not known if this is a partial revertant of pho^c or removal of the second site lethal.

(Girton and Jeon, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

pho^cv

(Bhatia et al., 2010, González et al., 2008, Choi et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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