FB2024_03 , released June 25, 2024
Allele: Dmel\phoc
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General Information
Symbol
Dmel\phoc
Species
D. melanogaster
Name
FlyBase ID
FBal0039758
Feature type
allele
Associated gene
Dmel\pho
Associated Insertion(s)
gypsy{}phoc
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Breen and Duncan, 1986)

hypomorphic allele - genetic evidence

(Brown et al., 1998, Pelegri and Lehmann, 1994)
Mutagen
spontaneous
(Breen and Duncan, 1986)
Progenitor genotype
Associated Insertion(s)
gypsy{}phoc
Cytology
Description

7.5kb gypsy insertion within an 86bp intron in the 5' non-coding region of the transcript.

(Brown et al., 1998)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes, hemizygotes and heteroallelic with phoc die as pharate adults. Pupae exhibit transformation of antenna into legs, partial transformation of meso- and metathoracic legs into prothoracic, pattern duplications (presence of a sixth tarsal segment) and deficiencies in the legs (partial claw formation), partial transformation of abdominal segments to a more posterior identity and transformation of parovaria into spermathecia.

      (Girton and Jeon, 1994)

      pupal lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      phoc is a suppressor of phenotype of nanosunspecified

      (Pelegri and Lehmann, 1994)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Duncan.

      Comments
      Comments

      Homozygotes die before pharate adult stage and hemizygotes survive with a weak pho phenotype. This suggests lethality could be due to a second site lethal. Recombinants were isolated, one gave a homozygous viable pho phenotype, the pho allele is referred to as phocv, it is not known if this is a partial revertant of phoc or removal of the second site lethal.

      (Girton and Jeon, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      l(4)102EFc4
      l(4)29c
      (Breen and Duncan, 1986)
      pho102EFc-4
      phoc
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0011504
      References (4)