FlyBase Allele Report: Dmel\rut[2080]

General Information

Symbol

Dmel\rut²⁰⁸⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0032625

Feature type

allele

Associated gene

Dmel\rut

Associated Insertion(s)

P{lArB}rut²⁰⁸⁰

Carried in Construct

Also Known As

rutabaga²⁰⁸⁰, P{lArB}rut²⁰⁸⁰

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

P-element activity

(Levin et al., 1992)

Delta2-3 transposase

(Han et al., 1996)

Progenitor genotype

P{lArB}A4.1M2

(Han et al., 1996)

Associated Insertion(s)

P{lArB}rut²⁰⁸⁰

Cytology

Description

P{lArB} insertion within 200bp upstream of the presumed transcription start site.

(Han et al., 1996)

Allele components

Component

Use(s)

Inserted element

P{lArB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of alcohol use disorder

CEA

(Moore et al., 1998)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurofibromatosis

modeled by Nf1^P2

(Tong et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Blow et al., 2005)

abnormal learning

(Liu et al., 2009, Beck et al., 2000, Zars et al., 2000)

abnormal memory

(Buchanan and Davis, 2010, Tan et al., 2010, Blum et al., 2009, Claridge-Chang et al., 2009, Lu et al., 2007, Liu et al., 2006, Honjo and Furukubo-Tokunaga, 2005, Mao et al., 2004, McGuire et al., 2003, Schwaerzel et al., 2003, Schwaerzel et al., 2002, Zars et al., 2000, Zars et al., 2000)

abnormal memory (with rut¹)

(Blum et al., 2009)

abnormal memory | adult stage

(Murakami et al., 2017, Xie et al., 2013)

abnormal memory | larval stage

(Silva et al., 2015)

abnormal memory | recessive

(Gervasi et al., 2010)

abnormal neuroanatomy | third instar larval stage

(Koon and Budnik, 2012)

abnormal neurophysiology | adult stage

(van Swinderen, 2007)

abnormal optomotor response | adult stage

(van Swinderen, 2007)

abnormal smell perception

(Honjo and Furukubo-Tokunaga, 2005)

abnormal starvation stress response | third instar larval stage

(Koon et al., 2011)

abnormal taste perception

(Honjo and Furukubo-Tokunaga, 2005)

abnormal visual behavior | adult stage

(van Swinderen, 2007)

chemical sensitive

(Moore et al., 1998)

Phenotype Manifest In

adult brain

(van Swinderen, 2007)

axon & motor neuron | conditional ts

(Zhong and Wu, 2004)

embryonic/larval neuromuscular junction | third instar larval stage

(Koon and Budnik, 2012, Koon et al., 2011)

multidendritic neuron | third instar larval stage

(Koon et al., 2011)

Detailed Description

Statement

Reference

rut²⁰⁸⁰ homozygous mutant adults have a similar increase in aversive olfactory 24 h memory observed when the recall environment better matches the training environment (presence of copper grid) to controls.

(Zhao et al., 2019)

rut²⁰⁸⁰ homozygous adults display a significant decrease in intermediate-term (3h after conditioning) olfactory memory, regardless of whether the individuals are subjected or not to cold-shock anesthesia after conditioning, as compared to controls.

(Murakami et al., 2017)

rut²⁰⁸⁰ mutant larvae have a significantly reduced ability to form aversive associative olfactory memories in response to high salt concentration compared to wild-type controls.

(Silva et al., 2015)

As in wild type, rut²⁰⁸⁰ mutant males exhibit inhibition of female contact-induced male-male aggression seen in wild type males that have previously been exposed to females.

(Yuan et al., 2014)

rut²⁰⁸⁰ mutant adults fail to form 3 h aversive memory, unlike controls; they do not have difference in naive preferences for odors, shock or sugar, compared to controls.

(Xie et al., 2013)

Mutant third instar larvae show a significant decrease in the number of natural synaptopods (motile filopodia-like extensions) at type II neuromuscular junctions compared to wild type, but the number of type II boutons is normal.

(Koon and Budnik, 2012)

rut²⁰⁸⁰ mutant third instar larval neuromuscular junctions display significantly fewer natural synaptopods than wild-type flies.

Application of 10υM octopamine induces synaptopod formation in rut²⁰⁸⁰ homozygous neuromuscular junctions.

rut²⁰⁸⁰ mutant larvae display normal locomotor activity but exhibit an elimination of the starvation response.

(Koon et al., 2011)

In training trial assays, where flies are repeatedly trained with odor avoidance assays, rut²⁰⁸⁰ flies perform poorly even after 15 trials, at which point their performance is not significantly different to controls. As early as 30 minutes after training, the memory of rut²⁰⁸⁰ flies is abolished.

(Buchanan and Davis, 2010)

rut²⁰⁸⁰/Y males show a defect in 2 hour memory compared to wild type.

(Gervasi et al., 2010)

Mutants show a significant impairment in 3 minute memory after olfactory conditioning compared to wild-type flies.

(Tan et al., 2010)

Homozygous and rut¹/rut²⁰⁸⁰ adults show severely reduced 2 minute memory after a single aversive Pavlovian training session. These adults also show severely reduced memory performance 24 hours after either ten massed or ten spaced sessions of training.

(Blum et al., 2009)

Mutant flies trained by associating an odour with an electric shock do not avoid the odour after training, in contrast to wild-type flies.

Mutant flies are defective in action-contingent olfactory learning.

(Claridge-Chang et al., 2009)

Recently eclosed flies, mutant for rut²⁰⁸⁰ show increased sleep after social enrichment, although sleep in 3-4 day old adult rut²⁰⁸⁰ mutants does not respond to changes in the social environment.

(Donlea et al., 2009)

rut²⁰⁸⁰ flies show significantly lower learning after aversive olfactory conditioning (flies trained to associate odors with an electric shock) compared to controls.

(Liu et al., 2009)

Immediate memory after one training session and one-day memory after spaced training is impaired in homozygous flies in a Pavlovian olfactory learning assay.

(Lu et al., 2007)

rut²⁰⁸⁰ mutants exhibit significantly shorter life spans compared to controls.

(Tong et al., 2007)

Mutant flies show some responsiveness to a novel visual stimulus after a transition (assayed by measuring local field potential activity in the brain), but without the sustained 9-second selection characteristic of wild-type flies, and the mutant flies also respond strongly in the 10- to 20-Hz range.

Mutant animals are not distracted by a competing visual stimulus added to an optomotor assay, in contrast to wild-type flies.

(van Swinderen, 2007)

rut²⁰⁸⁰ abolishes the ability of socially enriched adult flies to show decreases in sleep after exposure to social impoverishment.

(Ganguly-Fitzgerald et al., 2006)

Mutant flies have normal visual flight control, heat avoidance and pattern discrimination in a visual pattern memory assay, but visual pattern memory is impaired.

(Liu et al., 2006)

rut²⁰⁸⁰ mutant flies show resistance to V. cholerae infection compared to controls.

(Blow et al., 2005)

rut²⁰⁸⁰ mutant larvae, trained with LIN/SUC, LIN with DW, or SUC alone fail to exhibit a Response Index (RI) increase, unlike wild-type flies. The gustatory response for SUC is slightly lower in rut²⁰⁸⁰ larvae than in wild-type flies.

(Honjo and Furukubo-Tokunaga, 2005)

rut²⁰⁸⁰ flies show a lower calcium response from the dorsal paired neurons than wild-type flies following training consisting of 10s of CS odour, a single electric shock 9s late, 30s fresh air and a further 10s of CS odor.

(Yu et al., 2005)

Shows normal anasthesia resistant memory (ARM).

(Isabel et al., 2004)

rut²⁰⁸⁰ mutants show significantly impaired performance in tests of 3 minute memory after classical conditioning for odors.

(Mao et al., 2004)

When raised at room temperature or at 25^oC, the motor axon terminals of rut²⁰⁸⁰ larvae show a similar level of arborization to wild-type larvae. However, the motor nerve termini of wild-type larvae raised at 30^oC show greatly increased levels of branching and variscosities, while no such large increase in terminal projection.

(Zhong and Wu, 2004)

The volume of the antennal lobe and of individual DM2, V and DM6 glomeruli in 6 day old adults is not altered compared to wild type.

The response of mutant flies to benzaldehyde is not affected by previous exposure to the odorant. The volume of the antennal lobe neuropile and the DM2, V and DM6 glomeruli is not altered in response to benzaldehyde, in contrast to the adaptive response seen in wild-type flies in response to benzaldehyde.

(Devaud et al., 2003)

rut²⁰⁸⁰ flies have impaired olfactory learning compared to wild-type flies; they are less likely to learn to avoid an odor having experienced it together with an electric shock and are also less likely to be attracted to an odor if it has been combined with a sugar reward. These flies have the same ability as wild type to respond spontaneously to electric shocks, sugar and the odorants EA and IA.

(Schwaerzel et al., 2003)

rut²⁰⁸⁰ mutant flies exhibit memory defects that increase over time, decaying from about 30% of the wild-type level at 3 mins to 20% at 30 mins, and to about zero by 3 hours after training.

(Schwaerzel et al., 2002)

Larval molting profile of rut²⁰⁸⁰/rut²⁰⁸⁰ and rut²⁰⁸⁰/rut¹⁷⁸ larvae appears normal.

(Venkatesh et al., 2001)

Single-trial short program training in an olfactory learning assay shows that rut²⁰⁸⁰ flies perform poorly immediately after conditioning. The mutants are sensitive to two-trial, spaced conditioning over two-trial, massed conditioning, behaving in this respect qualitatively like control flies. After mock training, odour avoidance to benzaldehyde or octanol is not significantly different to wild-type flies.

(Beck et al., 2000)

Both training and memory test avoidance performances are lower in rut mutant flies. The test is based on a spatial learning paradigm with a heat punishment procedure. Thermosensitivity of rut²⁰⁸⁰ flies is indistingushable from that of wild type flies over the temperature ranges employed in the paradigm.

(Zars et al., 2000)

Mutants show defective olfactory short term memory.

(Zars et al., 2000)

Hemizygous males show increased sensitivity to ethanol in an inebriometer assay.

(Moore et al., 1998)

After presentation of electric shock with a first odour, rut²⁰⁸⁰ flies show a strongly reduced avoidance of a second, different odour compared to wild-type flies.

(Preat, 1998)

In an odour avoidance paradigm exhibits significantly reduced learning.

(Levin et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

rut²⁰⁸⁰ has abnormal memory | adult stage phenotype, enhanceable by Rgk1^Δ/Rgk1^Δ

(Murakami et al., 2017)

Suppressed by

Statement

Reference

rut²⁰⁸⁰ has chemical sensitive phenotype, suppressible by amn^chpd

(Moore et al., 1998)

NOT suppressed by

Statement

Reference

rut²⁰⁸⁰ has abnormal learning phenotype, non-suppressible by Scer\GAL4^c747/Rdl^{RNAi.8-10.UAS}

(Liu et al., 2009)

Enhancer of

Statement

Reference

rut²⁰⁸⁰ is an enhancer of abnormal memory | adult stage | recessive phenotype of Rgk1^Δ

(Murakami et al., 2017)

rut²⁰⁸⁰/rut¹⁷⁸ is an enhancer of abnormal developmental rate | recessive phenotype of Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut¹⁷⁸ is an enhancer of lethal | larval stage | recessive phenotype of Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut²⁰⁸⁰ is an enhancer of abnormal developmental rate | recessive phenotype of Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut²⁰⁸⁰ is an enhancer of lethal | pupal stage | recessive phenotype of Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut²⁰⁸⁰ is an enhancer of abnormal developmental rate | recessive phenotype of Itpr^90B.0

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut²⁰⁸⁰ is an enhancer of lethal | larval stage | recessive phenotype of Itpr^90B.0

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut¹⁷⁸ is an enhancer of lethal | pupal stage | recessive phenotype of Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut¹⁷⁸ is an enhancer of abnormal developmental rate phenotype of Itpr^90B.0/Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut¹⁷⁸ is an enhancer of lethal | larval stage phenotype of Itpr^90B.0/Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut¹⁷⁸ is an enhancer of lethal | pupal stage phenotype of Itpr^90B.0/Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut²⁰⁸⁰ is an enhancer of abnormal developmental rate phenotype of Itpr^90B.0/Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut²⁰⁸⁰ is an enhancer of lethal | larval stage phenotype of Itpr^90B.0/Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

rut²⁰⁸⁰/rut²⁰⁸⁰ is an enhancer of lethal | pupal stage phenotype of Itpr^90B.0/Itpr⁰⁵⁶¹⁶

(Venkatesh et al., 2001)

Suppressor of

Statement

Reference

rut²⁰⁸⁰ is a suppressor of chemical sensitive | recessive phenotype of amn^chpd

(Moore et al., 1998)

Other

Statement

Reference

Itpr⁰⁵⁶¹⁶, rut²⁰⁸⁰ has lethal | recessive | larval stage phenotype

(Venkatesh et al., 2001)

Phenotype Manifest In

Other

Statement

Reference

Itpr⁰⁵⁶¹⁶, rut²⁰⁸⁰/rut¹⁷⁸ has embryonic/larval tracheal system phenotype

(Venkatesh et al., 2001)

Itpr⁰⁵⁶¹⁶, rut²⁰⁸⁰ has embryonic/larval tracheal system phenotype

(Venkatesh et al., 2001)

Itpr^90B.0, rut²⁰⁸⁰/rut¹⁷⁸ has embryonic/larval tracheal system phenotype

(Venkatesh et al., 2001)

Itpr^90B.0, rut²⁰⁸⁰ has embryonic/larval tracheal system phenotype

(Venkatesh et al., 2001)

Itpr^90B.0/Itpr⁰⁵⁶¹⁶, rut²⁰⁸⁰ has embryonic/larval tracheal system phenotype

(Venkatesh et al., 2001)

Itpr^90B.0/Itpr⁰⁵⁶¹⁶, rut²⁰⁸⁰/rut¹⁷⁸ has embryonic/larval tracheal system phenotype

(Venkatesh et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Adult males that are both hemizygous for rut²⁰⁸⁰ and homozygous for Rgk1^Δ exhibit a severe decrease in cold-shock anesthesia-resistant intermediate-term olfactory memory (3h after conditioning) as compared to adult males that are only hemizygous for rut²⁰⁸⁰ or only homozygous for Rgk1^Δ.

(Murakami et al., 2017)

The reduction in the number of natural synaptopods (motile filopodia-like extensions) at the type II neuromuscular junction which is seen in rut²⁰⁸⁰ third instar larvae is not altered if the larvae are also mutant for oa2¹.

(Koon and Budnik, 2012)

Scer\GAL4^c747-mediated expression of Rdl^{dsRNA.8-10.Scer\UAS} does not suppress the low learning performance of rut²⁰⁸⁰ flies after aversive olfactory conditioning.

(Liu et al., 2009)

amn^chpd rut²⁰⁸⁰ double mutants do not show increased sensitivity to ethanol in an inebriometer assay, although each single mutant does show increased sensitivity to ethanol in an inebriometer assay.

(Moore et al., 1998)

Xenogenetic Interactions

Statement

Reference

Expression of Bper\ptxA^act.Scer\UAS for 2 hours at 32[o]C (under the control of both Scer\GAL4^Mef2.247 and Scer\GAL80^ts.αTub84B) in a rut²⁰⁸⁰ heterozygous background results in a reduction in learning compared to in a wild-type background, although this is not significant, indicating an additive interaction.

(Ferris et al., 2006)

Complementation and Rescue Data

Fails to complement

rut¹

(Levin et al., 1992)

Rescued by

rut²⁰⁸⁰ is rescued by Scer\GAL4^Tdc2.PC/rut^UAS.cZa

(Koon et al., 2011)

rut²⁰⁸⁰ is rescued by rut^UAS.cZa/Scer\GAL4^P2.4.Pdf

(Donlea et al., 2009)

rut²⁰⁸⁰ is rescued by Scer\GAL4^{elav.Switch.PO}/rut^UAS.cZa

(Donlea et al., 2009)

rut²⁰⁸⁰ is rescued by Scer\GAL4^Mz717/rut^UAS.cZa

(Donlea et al., 2009)

rut²⁰⁸⁰ is rescued by Scer\GAL4^121Y/rut^UAS.cZa

(Liu et al., 2006)

rut²⁰⁸⁰ is rescued by rut^UAS.cZa/Scer\GAL4^elav.PLu

(Liu et al., 2006)

rut²⁰⁸⁰ is rescued by Scer\GAL4^104Y/rut^UAS.cZa

(Liu et al., 2006)

rut²⁰⁸⁰ is rescued by rut^UAS.cZa

(Blow et al., 2005)

rut²⁰⁸⁰ is rescued by Scer\GAL4^{Mef2.247.Switch}/rut^UAS.cZa

(Mao et al., 2004)

rut²⁰⁸⁰ is rescued by Scer\GAL4^c747/rut^UAS.cZa

(McGuire et al., 2003)

rut²⁰⁸⁰ is rescued by Scer\GAL4^Mef2.247/rut^UAS.cZa

(McGuire et al., 2003)

rut²⁰⁸⁰ is rescued by Scer\GAL4^Mef2.247/rut^UAS.cZa

(Schwaerzel et al., 2002)

rut²⁰⁸⁰ is rescued by Scer\GAL4^c271/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is rescued by Scer\GAL4^c522/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is rescued by Scer\GAL4^c747/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is rescued by rut^UAS.cZa/Scer\GAL4^elav.PLu

(Zars et al., 2000)

rut²⁰⁸⁰ is rescued by Scer\GAL4^238Y/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is rescued by Scer\GAL4^30Y/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is rescued by Scer\GAL4^H24/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is rescued by Scer\GAL4^c747/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is rescued by Scer\GAL4^Mef2.247/rut^UAS.cZa

(Zars et al., 2000)

Partially rescued by

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^5-HT1B.PY/rut^UAS.cZa

(Xie et al., 2013)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^Tab2-201Y/rut^UAS.cZa

(Blum et al., 2009)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^Mef2.247/rut^UAS.cZa

(Blum et al., 2009)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^ey-OK107/rut^UAS.cZa

(Blum et al., 2009)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^c309/rut^UAS.cZa

(Blum et al., 2009)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^NP6510/rut^UAS.cZa

(Liu et al., 2006)

rut²⁰⁸⁰ is partially rescued by rut^UAS.cZa/Scer\GAL4^NP6561

(Liu et al., 2006)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^c205/rut^UAS.cZa

(Liu et al., 2006)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^4G/rut^UAS.cZa

(Zhong and Wu, 2004)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^Mef2.247/rut^UAS.cZa

(Schwaerzel et al., 2003)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^c115/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^Tab2-201Y/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is partially rescued by Scer\GAL4^elav-C155/rut^UAS.cZa

(Zars et al., 2000)

Not rescued by

rut²⁰⁸⁰ is not rescued by Scer\GAL80^Mef2.mb247/Scer\GAL4^5-HT1B.PY/rut^UAS.cZa

(Xie et al., 2013)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^c305a/rut^UAS.cZa

(Xie et al., 2013)

rut²⁰⁸⁰ is not rescued by rut^UAS.cZa/Scer\GAL4^GH146

(Blum et al., 2009)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^NP2320/rut^UAS.cZa

(Liu et al., 2006)

rut²⁰⁸⁰ is not rescued by rut^UAS.cZa/Scer\GAL4^BG487

(Zhong and Wu, 2004)

rut²⁰⁸⁰ is not rescued by rut^UAS.cZa/Scer\GAL4^103Y

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^121Y/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^insc-Mz1407/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^238Y/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^30Y/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^dbr-72Y/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^Alp4-c232/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^Tab2-201Y/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^H24/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^c492b/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by rut^UAS.cZa/Scer\GAL4^lilli-189Y

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by Scer\GAL4^Alp4-c232/rut^UAS.cZa

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by rut^UAS.cZa/Scer\GAL4^lilli-189Y

(Zars et al., 2000)

rut²⁰⁸⁰ is not rescued by rut^UAS.cZa/Scer\GAL4^17d

(Zars et al., 2000)

Comments

Expression of rut^Scer\UAS.cZa under the control of Scer\GAL4^Tdc2.PC rescues the decrease in synaptopods seen at third instar larval neuromuscular junctions in rut²⁰⁸⁰ mutants.

Expression of rut^Scer\UAS.cZa under the control of Scer\GAL4^Tdc2.PC rescues the response to starvation block seen in rut²⁰⁸⁰ mutants.

(Koon et al., 2011)

Expression of rut^Scer\UAS.cZa under the control of Scer\GAL4^P2.4.Pdf restores the increase in daytime sleep and daytime sleep-bout duration in rut²⁰⁸⁰ mutants.

Expression of rut^Scer\UAS.cZa under the control of Scer\GAL4^{elav.Switch.PO} restores the increase in daytime sleep and daytime sleep-bout duration in rut²⁰⁸⁰ mutants.

(Donlea et al., 2009)

Expression of rut^Scer\UAS.cZa is able to suppress the increased resistance to V. cholerae infection seen in rut²⁰⁸⁰ mutant flies in the absence of a Scer\GAL4 driver.

(Blow et al., 2005)

The short term memory deficit of rut²⁰⁸⁰ mutants is rescued by rut^Scer\UAS.cZa; Scer\GAL4^{Mef2.247.Switch} after feeding with 500μM RU486 for 2 days as adults. Shorter RU486 treatments produced incomplete rescue. Animals treated with RU486 during development but not as adults show no rescue 7-10 days after eclosion.

(Mao et al., 2004)

Expression of rut^Scer\UAS.cZa in a sunset of nerves, under the control of Scer\GAL4^4G, increases levels of motor axon termini arborization in rut²⁰⁸⁰ larvae raied at 30^oC, but does not increase levels to those seen in wild-type larvae.

(Zhong and Wu, 2004)

Expression of rut^Scer\UAS.cZa under the control of Scer\GAL4^Mef2.247 rescues the limited olfactory learning phenotype of rut²⁰⁸⁰ mutants.

(Schwaerzel et al., 2003)

MB-rescued rut²⁰⁸⁰ mutant flies (through expression of rut^Scer\UAS.cZa by Scer\GAL4²⁴⁷) show extinction and extinction control performance indistinguishable from wild-type flies.

(Schwaerzel et al., 2002)

Rescue statements based on rescue of the learning and 3 minute memory defect of rut²⁰⁸⁰ flies. Rescue of rut²⁰⁸⁰ by Scer\GAL4^c522 depends on specific insertion of P{UAS-rut.Z}. Rescue is evident with P{UAS-rut.Z}1 but not P{UAS-rut.Z}2.

(Zars et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9405

P{lArB}rut²⁰⁸⁰; P{UAS-rut.Z}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Rut²⁰⁸⁰

(Yu et al., 2021)

rut2080

(Blow et al., 2005, Gerber et al., 2003)

rut²⁰⁸⁰`

(Knapek et al., 2011)

rut^MB2080

rut^P2080

(Preat, 1998)

rutabaga²⁰⁸⁰

(Song et al., 2019, Claridge-Chang et al., 2009)

Name Synonyms

Rutabaga

(Blow et al., 2005)

rutabaga

(Blow et al., 2005)

rutabaga2080

(Ferris et al., 2006)

Secondary FlyBase IDs

FBal0032629

References (52)

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