FlyBase Allele Report: Dmel\ase[UAS.cBa]

General Information

Symbol

Dmel\ase^UAS.cBa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Brand

FlyBase ID

FBal0030517

Feature type

allele

Associated gene

Dmel\ase

Associated Insertion(s)

Carried in Construct

P{UAS-ase.B}

Also Known As

UAS-ase

Key Links

Transgenic product class

wild_type

(Brand et al., 1993)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Brand et al., 1993)

Mutagen

in vitro construct

(Brand et al., 1993)

Progenitor genotype

Carried in construct

P{UAS-ase.B}

Cytology

Description

UASt regulatory sequences drive expression of ase.

(Brand et al., 1993)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

ase

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates brain cancer

modeled by tll^UAS.cKa

(Hakes and Brand, 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^71B

(Wallace et al., 2000)

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

(Wildonger and Mann, 2005)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Wildonger and Mann, 2005)

visible, with Scer\GAL4^455.2

(Fuse et al., 1999)

visible, with Scer\GAL4^C-765

(Villa-Cuesta et al., 2003)

Phenotype Manifest In

chaeta | ectopic & mesothoracic tergum, with Scer\GAL4^C-765

(Villa-Cuesta et al., 2003)

embryonic/larval optic lobe, with Scer\GAL4^71B

(Wallace et al., 2000)

macrochaeta, with Scer\GAL4^hs.PB

(Brand et al., 1993)

macrochaeta | ectopic, with Scer\GAL4^455.2

(Fuse et al., 1999)

mechanosensory chaeta | ectopic, with Scer\GAL4^hs.PB

(Ayyar et al., 2010)

microchaeta, with Scer\GAL4^hs.PB

(Brand et al., 1993)

sense organ, with Scer\GAL4^hs.PB

(Brand et al., 1993)

sensillum campaniformium | ectopic & wing, with Scer\GAL4^C-765

(Villa-Cuesta et al., 2003)

sensory mother cell, with Scer\GAL4^pnr-MD237

(Wildonger and Mann, 2005)

wing sensillum | ectopic, with Scer\GAL4^C-765

(Villa-Cuesta et al., 2003)

Detailed Description

Statement

Reference

Expressing ase^UAS.cBa under the control of Scer\GAL4^{FRT.Rnor\Cd2.Act5C} has no effect on the mode of division of type III neuroblasts in FLP-out somatic clones in the optic lobe of third instar larvae.

(Mora et al., 2018)

No extra neuroblasts are seen when ase^Scer\UAS.cBa is expressed under the control of Scer\GAL4^wor.PA or Scer\GAL4^elav.PU.

(San-Juán and Baonza, 2011)

Flies expressing ase^Scer\UAS.cBa under the control of Scer\GAL4^hs.PB display in total an average of 10.9 ectopic bristles.

(Ayyar et al., 2010)

Ectopic expression of ase^Scer\UAS.cBa, driven by Scer\GAL4^pnr-MD237, stimulates sensory organ precursor development in the wing disc to a greater level than wild type.

(Wildonger and Mann, 2005)

Expression of ase^Scer\UAS.cBa under the control of Scer\GAL4^C-765 results in the formation of ectopic sensory organs, including ectopic bristles on the notum and ectopic bristles and sensilla campaniformia on the wing.

(Villa-Cuesta et al., 2003)

Expression of ase^Scer\UAS.cBa under the control of Scer\GAL4^71B results in a breakdown of the mitotic domain pattern that is present in the outer proliferation center (OPC) of the developing optic lobe.

(Wallace et al., 2000)

Expression of ase^Scer\UAS.cBa under the control of Scer\GAL4^455.2 results in extra macrochaetae.

(Fuse et al., 1999)

Penetrance and expressivity of bristle phenotype increased with respect to that of ase^hs.PB, but the spatial and temporal specificity of the effect is unaltered.

(Brand et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, ase^UAS.cBa has lethal | pupal stage phenotype, suppressible by nvy^UAS.cWa

(Wildonger and Mann, 2005)

Scer\GAL4^455.2, ase^UAS.cBa has visible phenotype, suppressible by esg^UAS.cFa

(Fuse et al., 1999)

Suppressor of

Statement

Reference

ase^UAS.cBa/Scer\GAL4^{FRT.Rnor\Cd2.Act5C} is a suppressor of abnormal neuroanatomy | somatic clone | third instar larval stage phenotype of Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, ato^UAS.cJa

(Mora et al., 2018)

ase^UAS.cBa/Scer\GAL4^{FRT.Rnor\Cd2.Act5C} is a suppressor of abnormal cell polarity | somatic clone | third instar larval stage phenotype of Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, ato^UAS.cJa

(Mora et al., 2018)

ase^UAS.cBa, Scer\GAL80^ts.αTub84B, Scer\GAL4^insc-Mz1407 is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4^insc-Mz1407, Scer\GAL80^ts.αTub84B, pnt^UAS.P1.cZa

(Zhu et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, ase^UAS.cBa has sensory mother cell phenotype, suppressible | partially by nvy^UAS.cWa

(Wildonger and Mann, 2005)

Scer\GAL4^455.2, ase^UAS.cBa has macrochaeta | ectopic phenotype, suppressible by esg^UAS.cFa

(Fuse et al., 1999)

Suppressor of

Statement

Reference

ase^UAS.cBa/Scer\GAL4^{FRT.Rnor\Cd2.Act5C} is a suppressor of inner optic anlage neuroblast | somatic clone | third instar larval stage phenotype of Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, ato^UAS.cJa

(Mora et al., 2018)

ase^UAS.cBa, Scer\GAL80^ts.αTub84B, Scer\GAL4^insc-Mz1407 is a suppressor | partially of embryonic/larval brain | ventral | larval stage phenotype of Scer\GAL4^insc-Mz1407, Scer\GAL80^ts.αTub84B, pnt^UAS.P1.cZa

(Zhu et al., 2011)

ase^UAS.cBa, Scer\GAL80^ts.αTub84B, Scer\GAL4^insc-Mz1407 is a suppressor | partially of larval ventral nerve cord | larval stage phenotype of Scer\GAL4^insc-Mz1407, Scer\GAL80^ts.αTub84B, pnt^UAS.P1.cZa

(Zhu et al., 2011)

ase^UAS.cBa, Scer\GAL80^ts.αTub84B, Scer\GAL4^insc-Mz1407 is a suppressor | partially of intermediate neuronal progenitor | ectopic | larval stage phenotype of Scer\GAL4^insc-Mz1407, Scer\GAL80^ts.αTub84B, pnt^UAS.P1.cZa

(Zhu et al., 2011)

ase^UAS.cBa/Scer\GAL4^hs.PB is a suppressor of mechanosensory chaeta | ectopic phenotype of sc^ase-1

(Ayyar et al., 2010)

ase^UAS.cBa is a suppressor | partially of adult thorax | dorsal & mechanosensory sensory organ phenotype of Scer\GAL4^pnr-MD237, nvy^UAS.cWa

(Wildonger and Mann, 2005)

ase^UAS.cBa is a suppressor | partially of sensory mother cell phenotype of Scer\GAL4^pnr-MD237, nvy^UAS.cWa

(Wildonger and Mann, 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of ase^Scer\UAS.cBa largely suppresses the production of ectopic intermediate neural progenitor-like cells seen in the type I neuroblasts of the ventral brain and ventral nerve cord when pnt^{Scer\UAS.P1.cZa} is expressed under the control of Scer\GAL4^insc-Mz1407.

(Zhu et al., 2011)

Expression of ase^Scer\UAS.cBa under the control of Scer\GAL4^hs.PB suppresses the mechanosensory bristle defects found in sc^ase-1 mutants. The number of defective bristles in sc^ase-1 flies is reduced from an average of 9.7 to 2.5 bristles per fly.

(Ayyar et al., 2010)

Co-expression of ase^Scer\UAS.cBa and nvy^Scer\UAS.cWa, both under the control of Scer\GAL4^pnr-MD237, leads to a phenotype that is an intermediate of the two phenotypes seen when each is expressed separately. Resulting larvae have few sensory organ precursors in the wing disc and adults have some bristles on the thorax.

(Wildonger and Mann, 2005)

The phenotype caused by expression of ase^Scer\UAS.cBa under the control of Scer\GAL4^455.2 is strongly suppressed by co-expression of esg^Scer\UAS.cFa.

(Fuse et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ase^Scer\UAS.cBa

ase^UAS.cBa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Brand

Secondary FlyBase IDs

References (22)

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