FB2024_03 , released June 25, 2024
Allele: Dmel\Polr2IV
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General Information
Symbol
Dmel\Polr2IV
Species
D. melanogaster
Name
FlyBase ID
FBal0030150
Feature type
allele
Associated gene
Dmel\Polr2I
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gamma ray
(Harrison et al., 1992)
Progenitor genotype
Caused by aberration
Df(3R)su(Hw)V
Cytology
Description

Deletion extends from the 5' control region to the first Cys residue.

(Harrison et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RpII15Z23/RpII15V transheterozygote survival is dependent on temperature: flies reared at 18oC never produce viable adults, at 25oC few survive to adulthood.

      (Harrison et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Polr2IV is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

      (Maixner et al., 1998)
      Other
      Statement
      Reference

      Polr2IV, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype

      (Maixner et al., 1998)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by RpII15V.

      (Maixner et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Polr2IV is rescued by Polr2ItKa

      (Kim et al., 1996)

      Polr2IV is rescued by Polr2I+t5.3

      (Harrison et al., 1992)
      Comments

      The lethality of homozygotes is rescued by RpII15tKa.

      (Kim et al., 1996)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Polr2IV
      RpII15V
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0058325
      References (4)