FlyBase Allele Report: Dmel\Rdl[1]

General Information

Symbol

Dmel\Rdl¹

Species

D. melanogaster

Name

FlyBase ID

FBal0030106

Feature type

allele

Associated gene

Dmel\Rdl

Associated Insertion(s)

Carried in Construct

Also Known As

Rdl-1

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(ffrench-Constant et al., 1991)

Progenitor genotype

Caused by aberration

In(3L)Rdl¹

Cytology

Description

Breakpoint in Rdl.

(Stilwell and ffrench-Constant, 1998)

Cytologically not visible.

(ffrench-Constant et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates epilepsy

modeled by kcc^DHS1

(Hekmat-Scafe et al., 2006)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Liu et al., 2007)

lethal - all die during embryonic stage | recessive

(Stilwell and ffrench-Constant, 1998)

some die during embryonic stage | recessive

(Stilwell and ffrench-Constant, 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

Rdl¹/Rdl¹¹ animals die during the late stages of embryogenesis.

(Stilwell and ffrench-Constant, 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Rdl[+]/Rdl¹ is a suppressor | partially of lethal - all die before end of P-stage phenotype of Adar^3.4.S.UAS, Scer\GAL4^Act5C.PI

(Li et al., 2014)

Rdl[+]/Rdl¹ is a suppressor of paralytic | recessive phenotype of kcc^DHS1

(Hekmat-Scafe et al., 2010)

Rdl[+]/Rdl¹ is a suppressor of bang sensitive | recessive phenotype of kcc^DHS1

(Hekmat-Scafe et al., 2006)

Other

Statement

Reference

Rdl¹, wake^GS17103 has abnormal sleep | dominant phenotype

(Liu et al., 2014)

Rdl¹, wake^D2 has abnormal sleep | dominant phenotype

(Liu et al., 2014)

Rdl¹, smi26D¹/smi26D[+] has abnormal locomotor behavior | dominant | female phenotype

(Anholt et al., 2003)

Rdl¹, smi26D¹/smi26D[+] has abnormal smell perception | dominant | female phenotype

(Anholt et al., 2003)

Rdl¹, smi26D¹ has abnormal locomotor behavior | dominant | female phenotype

(Anholt et al., 2003)

Rdl¹, smi26D¹ has abnormal smell perception | dominant | female phenotype

(Anholt et al., 2003)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Rdl¹/+ partially rescues the lethality of flies expressing Adar^{3.4.S.Scer\UAS} under the control of Scer\GAL4^Act5C.PI.

(Li et al., 2014)

Rdl¹/wake^D2 and Rdl¹/wake^GS17103 double heterozygotes show a significant increase in sleep latency compared to controls (this phenotype is not seen in any of the single heterozygotes).

qvr^EY04063/+ ; Rdl¹/+ and DAT^fmn/+ ; Rdl¹/+ double heterozygotes show no significant change in sleep latency compared to controls.

(Liu et al., 2014)

The bang-sensitive paralytic phenotype of homozygous kcc^DHS1 mutants is significantly suppressed by Rdl¹/+.

(Hekmat-Scafe et al., 2010)

The penetrance of the bang sensitive phenotype seen in kcc^DHS1 homozygous adults is reduced to 1% by Rdl¹/+.

(Hekmat-Scafe et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

1687

106453

Notes on Origin

Discoverer

Comments

Induced in a Rdl susceptible strain.

(ffrench-Constant et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rdl-1

(ffrench-Constant, 1993, ffrench-Constant et al., 1991)

Rdl¹

(Sanfilippo et al., 2024, Molina-Obando et al., 2019, Fisher et al., 2017, Li et al., 2014, Liu et al., 2014, Hekmat-Scafe et al., 2010, Christensen et al., 2007.10.29, Liu et al., 2007, Gresens et al., 2006.7.11, Hekmat-Scafe et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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