FB2024_03 , released June 25, 2024
Allele: Dmel\wakeGS17103
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General Information
Symbol
Dmel\wakeGS17103
Species
D. melanogaster
Name
FlyBase ID
FBal0295777
Feature type
allele
Associated gene
Dmel\wake
Associated Insertion(s)
P{GSV6}wakeGS17103
Carried in Construct
Also Known As
wakeD1
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - molecular evidence

    (Liu et al., 2014)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV6}wakeGS17103
    Cytology
    Description

    Insertion within the wake coding region, plus a deletion of approximately 1kb which includes the fifth coding exon of the CG42686 annotation (this annotation corresponded to part of wake).

    (Liu et al., 2014)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV6}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        wakeEY02219/wakeGS17103 and homozygous wakeGS17103 females show a significant reduction in total daily sleep relative to controls. Sleep bout duration is significantly decreased but there is no significant change in sleep bout number. Sleep latency is significantly increased. The reduction in total sleep and increase in sleep latency persist under constant darkness conditions in wakeGS17103 homozygotes. Sleep rebound is not reduced compared to controls in wakeGS17103 homozygotes.

        Under constant darkness conditions, period length and rhythm strength of circadian activity show no significant difference compared to controls.

        (Liu et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Other
        Statement
        Reference

        Rdl1, wakeGS17103 has abnormal sleep | dominant phenotype

        (Liu et al., 2014)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Rdl1/wakeGS17103 double heterozygotes show a significant increase in sleep latency compared to controls (this phenotype is not seen in either single heterozygote).

        qvrEY04063/+ ; wakeGS17103/+ and DATfmn/+ ; wakeGS17103/+ double heterozygotes show no significant change in sleep latency compared to controls.

        (Liu et al., 2014)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        wakeD1
        (Huang et al., 2020, Liu et al., 2014)
        wakeGS17103
        (Chen et al., 2022)
        wakeD1
        (Axelrod et al., 2023)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)