FB2024_03 , released June 25, 2024
Allele: Dmel\wakeEY02219
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General Information
Symbol
Dmel\wakeEY02219
Species
D. melanogaster
Name
FlyBase ID
FBal0157140
Feature type
allele
Associated gene
Dmel\wake
Associated Insertion(s)
P{EPgy2}wakeEY02219
Carried in Construct
Also Known As
EY02219, wakeP1
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Liu et al., 2014)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}wakeEY02219
Cytology
Description

Insertion within the wake coding region.

(Liu et al., 2014)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      wakeEY02219 homozygous adults exhibit a significant decrease in sleep duration during both day time and night time (ZT1-12 and ZT13-24, respectively) and a significant increase in sleep latency period (females only), as compared to controls.

      (Li et al., 2017)

      wakeEY02219/wakeGS17103 and homozygous wakeEY02219 females show a significant reduction in total daily sleep relative to controls. Sleep bout duration is significantly decreased but there is no significant change in sleep bout number. Sleep latency is significantly increased.

      (Liu et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      wakeEY02219 has short lived | male phenotype, suppressible by brp+t83.4

      (Huang et al., 2022)

      wakeEY02219 has abnormal sleep | adult stage phenotype, suppressible by Fbxl4Δ45/Fbxl4Δ45

      (Li et al., 2017)
      Suppressor of
      Statement
      Reference

      wakeEY02219/wakeEY02219 is a suppressor of abnormal sleep | adult stage phenotype of Fbxl4Δ45

      (Li et al., 2017)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      wakeEY02219, Fbxl4Δ45 double homozygotes do not exhibit the sleep defects exhibited by either of the single homozygotes.

      (Li et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      wakeGS17103

      (Liu et al., 2014)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the P{EPgy2}wakeEY02219 insertion reverts the reduced sleep and increased sleep latency seen in mutant flies.

      (Liu et al., 2014)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      CG17623EY02219
      CG42686EY02219
      CG45058EY02219
      EY02219
      (Huang et al., 2022, Zhang et al., 2015)
      wakeEY02219
      wakeP1
      (Huang et al., 2020, Liu et al., 2014)
      wakeey02219
      (Li et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)