FlyBase Allele Report: Dmel\Psc[Arp.1]

General Information

Symbol

Dmel\Psc^Arp.1

Species

D. melanogaster

Name

FlyBase ID

FBal0030047

Feature type

allele

Associated gene

Dmel\Psc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Cheng et al., 1994, Sharp et al., 1994, Adler et al., 1991, Brunk et al., 1991)

loss of function allele

(Martin and Adler, 1993)

Mutagen

P-element activity

(Brunk et al., 1991)

Progenitor genotype

Su(z)2^Arp1

(Martin and Adler, 1993, Brunk et al., 1991)

Cytology

Polytene chromosomes normal.

(Martin and Adler, 1993, Brunk et al., 1991)

Description

Approximately 20kb deletion at the 5' end of Psc.

(Adler et al., 1991)

Approximately 20kb deletion extending proximally from the site of the distal breakpoint in In(2R)Arp1. Single gene deletion of Psc.

(Brunk et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Brunk et al., 1991)

lethal - all die during embryonic stage | recessive

(Martin and Adler, 1993)

some die during embryonic stage | recessive

(Martin and Adler, 1993)

some die during larval stage | recessive

(Brunk et al., 1991)

Phenotype Manifest In

Detailed Description

Statement

Reference

No homeotic phenotype and the mutation cannot enhance the homeotic phenotypes of Pc group mutants (FBrf0049524).

(Cheng et al., 1994)

Abdominal clones fail to show clear evidence of bristle abnormalities or segmental transformations.

(Sharp et al., 1994)

Psc^Arp.1/Df(2R)Su(z)2-1.b8 embryos have severe head defects.

(Martin and Adler, 1993)

Psc^Arp.1 embryos in combination with Df(2R)Arp1.Fbf1a, Df(2R)vg-D or Df(2R)vg62 have a similar phenotype to Psc^Arp.1 homozygotes. Psc^Arp.1/Df(2R)Su(z)2-1.b8 or Psc^Arp.1/Df(2R)vg-B embryos have a similar phenotype to Df(2R)Arp1.Fbf1a/Df(2R)Su(z)2-1.b8 embryos. Embryos doubly mutant for Psc^Arp.1 and Asx⁵ show strong posteriorly directed segmental transformations; in most embryos the thoracic ventral setal belts (VSBs) resemble typical abdominal VSBs, and from two to eight VSBs have a typical A8 shape. Many embryos have abdominal-like VSBs on the head. Embryos doubly mutant for Psc^Arp.1 and Scm^D1 show strong posteriorly directed segmental transformations. There is severe erosion of the ventral setae in the second and third thoracic segments, any setae present on these segments appear to be primarily or entirely abdominal. Ectopic Fell hairs are seen in more than 75% of cases. Embryos doubly mutant for Psc^Arp.1 and Pcl⁵ show posteriorly directed segmental transformations. There is medial erosion of the ventral setae and ectopic Fell hairs are seen in approximately 60% of cases. Embryos doubly mutant for Psc^Arp.1 and pho^b show a mild anterior to posterior segmental transformation. There is medial erosion of the ventral setae and ectopic Fell hairs are seen in more than 75% of cases. Approximately 10% of embryos have large cuticular holes. Embryos doubly mutant for Psc^Arp.1 and Sce¹ have ectopic Fell hairs in approximately 30% of cases, and medial erosion of the VSBs. The Sce¹ phenotype of lack (or partial lack) of the fourth abdominal segment VSB is substantially enhanced.

(Adler et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Psc^Arp.1 is an enhancer of abdominal 4 ventral denticle belt phenotype of Sce¹

(Adler et al., 1991)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

Psc^14P4

(Brunk et al., 1991)

Fails to complement

Psc¹

(Brunk et al., 1991)

Psc^1.d20

(Brunk et al., 1991)

Psc^vgD

(Brunk et al., 1991)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Revertant.

(Brunk et al., 1991)

Comments

Fails to complement: Su(z)2^D.c16. Complements: Su(z)2¹. Complements: Su(z)2^1.a1. Complements: Su(z)2^1.b7. Complements: Su(z)2^Arp.1. Complements: Su(z)2^Arp.2. Complements: Su(z)2⁴. Complements: Su(z)3¹. Fails to complement: Su(z)3^1.y. Complements: Su(z)2^Arp1. Complements: Su(z)2^Arp.4. Complements: l(2)49Dc¹. Complements lethality of Su(z)2^Arp.1.

(Brunk et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Arp^1.DC11

(Brunk et al., 1991)

Psc^Arp-1

(Rastelli et al., 1993)

Psc^Arp.1

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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