FlyBase Allele Report: Dmel\Psc[vgD]

General Information

Symbol

Dmel\Psc^vgD

Species

D. melanogaster

Name

FlyBase ID

FBal0045021

Feature type

allele

Associated gene

Dmel\Psc

Associated Insertion(s)

Carried in Construct

Also Known As

Psc^vg-D

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Simon et al., 1992)

Mutagen

Progenitor genotype

Caused by aberration

Df(2R)vg-D

Cytology

Description

Distal break of Df(2R)vg-D falls in the Psc transcription unit.

(Simon et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygous males do not have ectopic sex combs on the second and third legs.

(Qi et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Flies doubly heterozygous for Psc^vgD and Su(z)2^vgD show a slight increase in double strand break (DSB) repair via homologous recombination and a corresponding decrease in DSB repair by nonhomologous end-joining compared to controls in a somatic DSB repair assay, when either w^hd80k17 or w^hd-y+ is used as the recipient allele bearing the target break site.

(Holmes et al., 2006)

rept⁰⁶⁹⁴⁵ shows little or no interaction (in terms of ectopic sex comb phenotype) when in double heterozygous combination with Psc^vgD.

(Qi et al., 2006)

No significant modification of the number of sex combs is seen in Psc^vgD/+ corto⁴²⁰/+ double heterozygotes compared to Psc^vgD/+ single heterozygotes.

(Lopez et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Psc¹

(Brunk et al., 1991)

Psc^Arp.1

(Brunk et al., 1991)

Comments

Images (0)