FB2024_03 , released June 25, 2024
Allele: Dmel\Psc1.d20
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General Information
Symbol
Dmel\Psc1.d20
Species
D. melanogaster
Name
FlyBase ID
FBal0030043
Feature type
allele
Associated gene
Dmel\Psc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Wu and Howe, 1995)
Mutagen
gamma ray
(Martin and Adler, 1993, Brunk et al., 1991)
X ray
(Wu and Howe, 1995)
Progenitor genotype
Psc1
(Wu and Howe, 1995, Brunk et al., 1991)
Caused by aberration
T(2;3)Psc1.d20
Cytology
Description

Break falls within Psc transcription unit.

(Martin and Adler, 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One copy of Psc1.d20 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)wm4.

      One copy of Psc1.d20 moderately suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

      (Doheny et al., 2008)

      A significant change in repression of the wH19.UZA gene compared to offspring from the same cross carrying the balancer chromosome is observed in Psc1.d20 flies.

      (Erhardt et al., 2003)

      Can show a dominant suppression on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosomes. Has no effect on pericentric and fourth chromosome insertions.

      (Cryderman et al., 1999)

      Isolated on the basis of reverting the lethal interaction of Psc1 with Su(z)21. In a z1, wis/Y background, Psc1.d20 produces an orange eye color slightly darker than that of z1, wis/Y;+/+ males.

      (Wu and Howe, 1995)

      Embryonic lethal or semi-lethal when heterozygous with ph-d2. Unhatched larvae carry segmentation defects or polarity defects.

      (McKeon et al., 1994)

      Reverts the lethal interaction of Psc1 and Su(z)21.

      (Martin and Adler, 1993)

      Reverts the lethal interaction of Psc1 with Su(z)21.

      (Brunk et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Psc1.d20 is a non-suppressor of visible phenotype of MycUAS.cZa, Scer\GAL4GMR.PF

      (Secombe et al., 2007)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Psc1.d20 is a non-suppressor of eye phenotype of MycUAS.cZa, Scer\GAL4GMR.PF

      (Secombe et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complements: Su(z)21. Complements: Su(z)2Arp.1.

      (Brunk et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      678.hhsm
      (Brunk et al., 1991)
      Psc1.d20
      (Doheny et al., 2008, Secombe et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)