FB2024_03 , released June 25, 2024
Allele: Dmel\Vm26AbQJ42
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General Information
Symbol
Dmel\Vm26AbQJ42
Species
D. melanogaster
Name
FlyBase ID
FBal0018017
Feature type
allele
Associated gene
Dmel\Vm26Ab
Associated Insertion(s)
Carried in Construct
Also Known As
fs(2)QJ42
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Schupbach and Wieschaus, 1991)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eggs laid by homozygous Vm26AbQJ42 females expressing Vm26AbC123S.C131S.C140S are collapsed and fail to hatch.

      Eggs laid by Vm26AbQJ42/Df(2L)Exel7024 females expressing Vm26AbC123S.C131S are collapsed and fail to hatch.

      Compared with wild-type , the hatching rate of eggs laid by homozygous Vm26AbQJ42 females expressing Vm26AbC123S.C140S is severely compromised. About half of the mutant eggs are collapsed and the remainder are slightly turgid, but clearly distinguishable from wild-type eggs.

      Most of the eggs laid by Vm26AbQJ42/Df(2L)Exel7024 or homozygous Vm26AbQJ42 females expressing Vm26AbC131S are either collapsed or only slightly turgid and fail to hatch.

      The hatching rate of Vm26AbC123S-expressing eggs derived from Vm26AbQJ42/Df(2L)Exel7024 females is somewhat lower than that of wild-type control.

      (Wu et al., 2010)

      Homozygous egg chambers show collapse of the endochorion in late oogenesis.

      (Elalayli et al., 2008)

      Eggs have a collapsed and flaccid shell due to the absence of a major vitelline membrane protein.

      (Schupbach and Wieschaus, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Vm26AbQJ42 is rescued by Vm26AbC140S

      (Wu et al., 2010)

      Vm26AbQJ42 is rescued by Vm26AbC140S/Df(2L)Exel7024

      (Wu et al., 2010)
      Partially rescued by

      Vm26AbQJ42 is partially rescued by Vm26AbC123S/Df(2L)Exel7024

      (Wu et al., 2010)
      Not rescued by

      Vm26AbQJ42 is not rescued by Vm26AbC123S.C131S/Df(2L)Exel7024

      (Wu et al., 2010)

      Vm26AbQJ42 is not rescued by Vm26AbC123S.C131S.C140S

      (Wu et al., 2010)

      Vm26AbQJ42 is not rescued by Vm26AbC131S/Df(2L)Exel7024

      (Wu et al., 2010)

      Vm26AbQJ42 is not rescued by Vm26AbC123S.C140S

      (Wu et al., 2010)
      Comments

      Eggs laid by homozygous Vm26AbQJ42 females expressing Vm26AbC123S.C131S.C140S are collapsed and fail to hatch.

      Eggs laid by Vm26AbQJ42/Df(2L)Exel7024 females expressing Vm26AbC123S.C131S are collapsed and fail to hatch.

      Compared with wild-type , the hatching rate of eggs laid by homozygous Vm26AbQJ42 females expressing Vm26AbC123S.C140S is severely compromised. About half of the mutant eggs are collapsed and the remainder are slightly turgid, but clearly distinguishable from wild-type eggs.

      Most of the eggs laid by Vm26AbQJ42/Df(2L)Exel7024 or homozygous Vm26AbQJ42 females expressing Vm26AbC131S are either collapsed or only slightly turgid and fail to hatch.

      The hatching rate of Vm26AbC123S-expressing eggs derived from Vm26AbQJ42/Df(2L)Exel7024 females is somewhat lower than that of wild-type control.

      The hatching rate of Vm26AbC140S-expressing eggs derived from Vm26AbQJ42/Df(2L)Exel7024 or homozygous Vm26AbQJ42 females is comparable to wild-type control.

      (Wu et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (12)