FlyBase Allele Report: Dmel\vg[79d5]

General Information

Symbol

Dmel\vg^79d5

Species

D. melanogaster

Name

FlyBase ID

FBal0017947

Feature type

allele

Associated gene

Dmel\vg

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Paumard-Rigal et al., 1998)

Mutagen

gamma ray

(Williams and Bell, 1988, Alexandrov and Alexandrova, 1987)

neutron

(Williams and Bell, 1988, Alexandrov and Alexandrova, 1987)

irradiation

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)

spontaneous

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Alexandrov and Alexandrova, 1987)

Description

Small deletion within the vg locus.

(Heslip and Hodgetts, 1994)

Deletion of the 3' end of intron 2 and the 5' end of exon 2.

(Silber et al., 1993)

Small deletion within the Ddc locus.

(Heslip et al., 1992)

Deletion removes 5' end of exon 3.

(Williams et al., 1991)

400bp deletion of vg sequences. Distal endpoint removes 28bp of the downstream exon.

(Williams et al., 1990)

deletion from + 7 to + 8; '+' values to right (distal); 0 coordinate assigned to insert position of vg²¹; Williams, Atkin and Bell (1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:12,891,094..12,891,494 [+]

Comment:

~400bp deletion in intron2/exon3. The downstream endpoint is mapped at the sequence level (FBrf0052606). The 5' endpoint is approximate, (400 bases upstream of sequenced endpoint).

(Williams et al., 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive

(Silber et al., 1993)

female fertile

(Alexandrov and Alexandrova, 1987)

male fertile

(Alexandrov and Alexandrova, 1987)

viable

(Williams et al., 1990)

visible

(Rabinow and Birchler, 1990, Williams et al., 1990)

visible | recessive

(Paumard-Rigal et al., 1998)

visible | recessive | cold sensitive

(Silber et al., 1997)

Phenotype Manifest In

wing

(Paumard-Rigal et al., 1998, Rabinow and Birchler, 1990, Williams et al., 1990, Alexandrov and Alexandrova, 1987)

wing | cold sensitive

(Silber et al., 1997)

Detailed Description

Statement

Reference

Homozygotes have gaps in the wing margin.

(Paumard-Rigal et al., 1998)

Flies have notches at the wing tips. Wing length increases with increasing temperature.

(Silber et al., 1997)

vg^79d5 males that are also mutant for mle⁴ show less severe phenotype than females also mutant for mle⁴.

(Hiebert and Birchler, 1994)

Homozygotes display sensitivity to aminopterin.

(Silber et al., 1993)

Strapped wing phenotype.

(Heslip et al., 1992)

Mild nicking of wing margin.

(Williams et al., 1991)

Homozygotes exhibit notched wings.

(Rabinow and Birchler, 1990)

Strap wing phenotype.

(Williams et al., 1990)

Homozygotes have a vg^np wing phenotype. Postscutellars and halteres are wild-type. vg^79d5/vg^83b27 transheterozygotes have wild-type wings, halteres and postscutellars.

(Alexandrov and Alexandrova, 1987)

homozygous wing phenotype like that of vg^np halteres present postscutellar bristles present homozygous viable female-fertile?

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

vg^79d5 is an enhancer of visible | recessive phenotype of sd¹

(Paumard-Rigal et al., 1998)

vg^79d5 is an enhancer of visible | recessive phenotype of sd^ETX4

(Paumard-Rigal et al., 1998)

Phenotype Manifest In

Suppressed by

Statement

Reference

sd^ETX4, vg^79d5/vg¹ has wing phenotype, suppressible by sd::vg^UAS.sdTEA/Scer\GAL4^vg.PM

(Srivastava et al., 2002)

Enhancer of

Statement

Reference

vg^79d5/vg¹ is an enhancer of wing phenotype of sd^ETX4

(Srivastava et al., 2002)

vg^79d5 is an enhancer of wing phenotype of sd¹

(Paumard-Rigal et al., 1998)

vg^79d5 is an enhancer of wing phenotype of sd^ETX4

(Paumard-Rigal et al., 1998)

vg^79d5 is an enhancer of adult thorax & macrochaeta phenotype of sd^ETX4

(Paumard-Rigal et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

sd^ETX4, vg¹/vg^79d5 wings are very small and deformed. The addition of sd::vg^{Scer\UAS.sdTEA} (driven by Scer\GAL4^vg.PM) significantly rescues the wing defects.

(Srivastava et al., 2002)

sd^ETX4 vg^79d5 double homozygotes show a significant reduction in wing size and an uplifting of the postscutellar bristles, similar to the phenotype of vg¹ homozygotes. A similar phenotype is seen in sd¹ vg^79d5 double homozygotes. Flies heterozygous for vg^79d5 in a sd^ETX4 or sd¹ background have a phenotype almost as strong as sd^ETX4 vg^79d5 or sd¹ vg^79d5 double homozygotes.

(Paumard-Rigal et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Induced in: Mature spermatozoon.

(Alexandrov and Alexandrova, 1987)

Comments

Weak vg allele.

(Williams et al., 1991)

"irradiation" was stated as tentative. "spontaneous" was stated as tentative.

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

vg^79d5

Name Synonyms

Secondary FlyBase IDs

References (15)

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