FB2024_03 , released June 25, 2024
Allele: Dmel\sd1
Open Close
General Information
Symbol
Dmel\sd1
Species
D. melanogaster
Name
FlyBase ID
FBal0015347
Feature type
allele
Associated gene
Dmel\sd
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Paumard-Rigal et al., 1998)
Mutagen
X ray
(Campbell et al., 1991)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Campbell et al., 1991)
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sd1/+ adults exhibit jagged wing margins.

      (Dutta and Li, 2017)

      sd1 mutant flies have scalloped wings.

      (Jin et al., 2013)

      sd1/Df(1)Exel6251, sd1/sdΔB and sd1/sdΔC flies have rudimentary wings.

      (Zhang et al., 2008)

      Homozygotes have gaps in the wing margin.

      (Paumard-Rigal et al., 1998)

      Pupae display gaps around the entire wing margin.

      (Jack and DeLotto, 1992)

      Ectopic bristles are never seen on the wing veins.

      (Campbell et al., 1991)

      RK1. Wing margins scalloped and veins thickened. Eyes slightly roughened. Does not overlap wild type. Additional defects noted are uplifting of posterior scutellar bristles, haltere diminution and ectopic bristles on the wing blade.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      sd1 has visible phenotype, enhanceable by brm2

      (Jin et al., 2013)

      sd1 has visible phenotype, enhanceable by osa2

      (Jin et al., 2013)

      sd1 has visible | recessive phenotype, enhanceable by vg79d5

      (Paumard-Rigal et al., 1998)
      NOT suppressed by
      Statement
      Reference

      sd1 has visible | dominant phenotype, non-suppressible by tara1/tara[+]

      (Dutta and Li, 2017)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      sd1 has wing phenotype, enhanceable by brm2

      (Jin et al., 2013)

      sd1 has wing phenotype, enhanceable by osa2

      (Jin et al., 2013)

      sd1 has wing phenotype, enhanceable by vg79d5

      (Paumard-Rigal et al., 1998)
      NOT suppressed by
      Statement
      Reference

      sd1 has wing phenotype, non-suppressible by tara1/tara[+]

      (Dutta and Li, 2017)
      NOT Enhancer of
      Statement
      Reference

      sd[+]/sd1 is a non-enhancer of wing vein | ectopic phenotype of Snr1E1

      (Marenda et al., 2004)
      NOT Suppressor of
      Statement
      Reference

      sd[+]/sd1 is a non-suppressor of wing vein | ectopic phenotype of Snr1E1

      (Marenda et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of brm2 enhances the scalloped wing phenotype seen in sd1 mutant males.

      One copy of osa2 enhances the scalloped wing phenotype seen in sd1 mutant males.

      (Jin et al., 2013)

      sd1 vg79d5 double homozygotes show a significant reduction in wing size. Flies heterozygous for vg79d5 in a sd1 background have a phenotype almost as strong as sd1 vg79d5 double homozygotes.

      (Paumard-Rigal et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (1)
      Stocks (16)
      Notes on Origin
      Discoverer

      Gruneberg, 20th Oct. 1928.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (18)