FlyBase Allele Report: Dmel\Su(H)[16]

General Information

Symbol

Dmel\Su(H)¹⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0016317

Feature type

allele

Associated gene

Dmel\Su(H)

Associated Insertion(s)

Carried in Construct

Also Known As

Su(H)^S5, l(2)br7^S5

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Schweisguth and Lecourtois, 1998)

Mutagen

ethyl methanesulfonate

(Ashburner et al., 1999.10.12, Furukawa et al., 1992, Woodruff and Ashburner, 1979)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G1611A. Amino acid replacement: R222H.

(Furukawa et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:15,041,507..15,041,507 [+]

Nucleotide change:

G15041507A

Amino acid change:

R266H | Su(H)-PA; R266H | Su(H)-PC

(Furukawa et al., 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Woodruff and Ashburner, 1979)

visible

(Price et al., 1997)

visible | recessive | somatic clone

(Schweisguth and Lecourtois, 1998)

Phenotype Manifest In

macrochaeta | somatic clone

(Schweisguth and Lecourtois, 1998)

mesothoracic tergum & sensory organ cell & pupa | somatic clone

(Schweisguth and Lecourtois, 1998)

sensory organ cell | P-stage | somatic clone

(Schweisguth and Lecourtois, 1998)

wing

(Price et al., 1997)

Detailed Description

Statement

Reference

Homozygous clones produce "loss of bristle" and "multiple shaft" cuticular phenotypes. Homozygous clones in the pupal notum have an excess of sensory organ cells.

(Schweisguth and Lecourtois, 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Su(H)¹⁶ has visible phenotype, suppressible by E(Egfr)C12^C12

(Price et al., 1997)

Su(H)¹⁶ has visible phenotype, suppressible by E(Egfr)C22^C22

(Price et al., 1997)

Su(H)¹⁶ has visible phenotype, suppressible by H^C21

(Price et al., 1997)

Su(H)¹⁶ has visible phenotype, suppressible by H^C24

(Price et al., 1997)

Su(H)¹⁶ has visible phenotype, suppressible by H^C57

(Price et al., 1997)

Su(H)¹⁶ has visible phenotype, suppressible by H^C73

(Price et al., 1997)

Su(H)¹⁶ has visible phenotype, suppressible by vn^C221

(Price et al., 1997)

Su(H)¹⁶ has visible phenotype, suppressible by gro^C105

(Price et al., 1997)

Su(H)¹⁶ has visible phenotype, suppressible by E(Egfr)B56^B56

(Price et al., 1997)

Enhancer of

Statement

Reference

Su(H)¹⁶ is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

Su(H)¹⁶ has wing phenotype, suppressible by H^C21

(Price et al., 1997)

Su(H)¹⁶ has wing phenotype, suppressible by H^C24

(Price et al., 1997)

Su(H)¹⁶ has wing phenotype, suppressible by H^C57

(Price et al., 1997)

Su(H)¹⁶ has wing phenotype, suppressible by H^C73

(Price et al., 1997)

Su(H)¹⁶ has wing phenotype, suppressible by vn^C221

(Price et al., 1997)

Su(H)¹⁶ has wing phenotype, suppressible by gro^C105

(Price et al., 1997)

Su(H)¹⁶ has wing phenotype, suppressible by E(Egfr)B56^B56

(Price et al., 1997)

Su(H)¹⁶ has wing phenotype, suppressible by E(Egfr)C12^C12

(Price et al., 1997)

Su(H)¹⁶ has wing phenotype, suppressible by E(Egfr)C22^C22

(Price et al., 1997)

Enhancer of

Statement

Reference

Su(H)¹⁶ is an enhancer of wing phenotype of N^nd-1

(Rollins et al., 1999)

Su(H)¹⁶ is an enhancer of phenotype of mam¹⁰

(Fortini and Artavanis-Tsakonas, 1994)

Su(H)[+]/Su(H)¹⁶ is an enhancer of wing phenotype of N^nd-1

(Fortini and Artavanis-Tsakonas, 1994)

NOT Enhancer of

Statement

Reference

Su(H)¹⁶ is a non-enhancer of macrochaeta phenotype of N^spl-1

(Rollins et al., 1999)

Suppressor of

Statement

Reference

Su(H)¹⁶ is a suppressor of wing vein phenotype of N^Ax-E2

(Rollins et al., 1999)

Su(H)¹⁶ is a suppressor of eye phenotype of N^spl-1

(Rollins et al., 1999)

NOT Suppressor of

Statement

Reference

Su(H)¹⁶ is a non-suppressor of macrochaeta phenotype of N^spl-1

(Rollins et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous Su(H)¹⁶ enhances the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96 flies.

(Helms et al., 1999)

Suppresses the eye phenotype of N^spl-1 but has little or no effect on the bristle phenotype.

(Rollins et al., 1999)

Notched wing phenotype of N^nd-1 dominantly enhanced by Su(H)¹⁶. Heterozygotes for mam¹⁰ also heterozygous for Su(H)¹⁶ show wing nicks. Su(H)¹⁶ dominantly suppresses the lethality of N^Ax-E2/N^Ax-9 transheterozygotes.

(Fortini and Artavanis-Tsakonas, 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Su(H)^226.1

(Rollins et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Littlewood.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

(Furukawa et al., 1992)

Su(H)¹⁶

Su(H)^S5

(Johannes and Preiss, 2002, Helms et al., 1999, Nellesen et al., 1998, Schweisguth and Lecourtois, 1998, Price et al., 1997, Furukawa et al., 1995, Fortini and Artavanis-Tsakonas, 1994)

l(2)br7^S5

(Ashburner, 1982, Woodruff and Ashburner, 1979)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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