FlyBase Allele Report: Dmel\Ser[Bd-3]

General Information

Symbol

Dmel\Ser^Bd-3

Species

D. melanogaster

Name

FlyBase ID

FBal0015418

Feature type

allele

Associated gene

Dmel\Ser

Associated Insertion(s)

roo{}Ser^Bd-3

Carried in Construct

Also Known As

Bd^G, Ser^Bd-G

Key Links

Allele class

cold sensitive antimorphic allele - genetic evidence

Mutagen

heat

Nature of the Allele

Allele class

cold sensitive antimorphic allele - genetic evidence

(Hukriede and Fleming, 1997)

Mutagen

heat

(Lindsley and Zimm, 1992)

Progenitor genotype

Associated Insertion(s)

roo{}Ser^Bd-3

Cytology

Description

Partial duplication of the Ser locus in close proximity to the normal Ser location and insertion of roo into the coding region. roo insertion causes premature truncation of the transcript deleting the extracellular Cys-rich region and transmembrane and intracellular domains.

(Hukriede and Fleming, 1997)

Molecular polymorphisms at 0 to 1.0 and 14 to 17 kb.

(Lindsley and Zimm, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval crystal cell

(Lebestky et al., 2003)

embryonic head

(Hukriede et al., 1997)

eye

(Lindsley and Zimm, 1992)

femur

(Hukriede et al., 1997)

haltere (with Ser^+r83k)

(Gu et al., 1995)

leg

(Hukriede et al., 1997)

mesothoracic metatarsus (with Ser^+r83k)

(Gu et al., 1995)

mesothoracic tarsal segment 2 (with Ser^+r83k)

(Gu et al., 1995)

metathoracic metatarsus (with Ser^+r83k)

(Gu et al., 1995)

metathoracic tarsal segment 2 (with Ser^+r83k)

(Gu et al., 1995)

mouth hook

(Hukriede et al., 1997)

prothoracic metatarsus (with Ser^+r83k)

(Gu et al., 1995)

prothoracic tarsal segment 2 (with Ser^+r83k)

(Gu et al., 1995)

tibia

(Hukriede et al., 1997)

wing

(Helms et al., 1999, Hukriede et al., 1997, Lindsley and Zimm, 1992, Fleming et al., 1990)

wing (with Ser^+r83k)

(Gu et al., 1995)

wing | anterior

(Hukriede and Fleming, 1997)

wing | distal

(Hukriede and Fleming, 1997)

wing | heat sensitive

(Couso et al., 1995)

wing blade

(Sachan et al., 2013)

wing margin

(Sachan et al., 2013)

Detailed Description

Statement

Reference

Heterozygous mutants have significantly fewer circulating crystal cells.

(Lebestky et al., 2003)

The combination of the Ser^Bd-3 and Ser^+r83k alleles in trans results in the development of a vestigial wing.

(Brennan et al., 1999)

Strong synergistic effects are seen in flies expressing H^Scer\UAS.cGa under the control of Scer\GAL4^T113 and also carrying Ser^Bd-3.

(Go et al., 1998)

Heterozygotes exhibit loss of anterior wing margin material with associated bristles and hairs. Ser^Bd-3/Ser^D transheterozygotes exhibit loss of distal wing margin material, similar to Ser^D heterozygotes. Heterozygotes with Ser^rev6-1 or Df(3R)Bd appear phenotypically identical to Ser^Bd-3 heterozygotes Heterozygotes with Df(3R)Dl-BX6 are lethal (due in part to a second site lethal on the Ser chromosome), a 'cleaned up' e Ser^Bd-3 chromosome when heterozygous with Df(3R)Dl-BX6 has reduced viability and survivors exhibit rough eyes, duplicated bristles and greatly reduced wing blades. Further replacement of proximal chromosomal regions (recombining P{lacZ-un3}Y488 insertion onto Ser chromosome) allows full viability when heterozygous with Df(3R)Dl-BX6, but still with severe wing phenotypes. Heterozygotes with Ser^Bd-3, Df(3R)Dl-M2, Df(3R)Dl-BX12 and Dl^B2 are viable and exhibit a severe wing phenotype. Ser^Bd-3/Ser^+r83k transheterozygotes are pupal lethal.

(Hukriede and Fleming, 1997)

Homozygotes die at the late embryo/early larval stage and exhibit defects in head structures, particularly in the development of the mouth hooks.

Heterozygotes with Ser^+r83k die as pharate adults with abnormalities in the leg such as fusion of the femur and tibial segments and loss of the wing blade.

(Hukriede et al., 1997)

Flies exposed to the restrictive temperature between 48-96 hours AEL display a ripped wing phenotype. Overall shape of the wing is also affected, narrower spacing between the longitudinal veins.

(Couso et al., 1995)

Ser^Bd-3 Ser^+r83k combination is lethal, flies die as pupae and when dissected from the pupal case they exhibit eye roughening, lack of wing blade and haltere material and fusion of the first and second tarsal segment of all six legs.

(Gu et al., 1995)

Like Ser^Bd-1 but more extreme; not overlapping wild type in stock. Balancers also reduced with no overlap. Partially suppressed by H. Schultz and Curry report recurrent small or welt-like eye effect that is not well understood but is in chromosome 3 and may be an effect of Ser^Bd-3. Ser^Bd-3/Ser^Bd-1 lethal. Dominant wing phenotype.

(Lindsley and Zimm, 1992)

Wing nicking phenotype.

(Fleming et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ser^Bd-3 has visible | adult stage phenotype, enhanceable by Kap-α3^S033513

(Sachan et al., 2013)

Ser^Bd-3 has visible | adult stage phenotype, enhanceable by Kap-α3^D93

(Sachan et al., 2013)

Ser^Bd-3 has visible | adult stage phenotype, enhanceable by Kap-α3^D165

(Sachan et al., 2013)

Suppressed by

Statement

Reference

Ser^Bd-3/Ser^+r83k has visible phenotype, suppressible | partially by N⁴¹⁴

(Brennan et al., 1999)

Ser^Bd-3/Ser^+r83k has visible phenotype, suppressible | partially by N^l93

(Brennan et al., 1999)

Ser^Bd-3/Ser^+r83k has visible phenotype, suppressible | partially by N^l1N-B

(Brennan et al., 1999)

Enhancer of

Statement

Reference

Ser^Bd-3 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

NOT Enhancer of

Statement

Reference

Ser^Bd-3 is a non-enhancer of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

NOT Suppressor of

Statement

Reference

Ser^Bd-3 is a non-suppressor of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Other

Statement

Reference

Hsc70-4¹⁹⁵, Ser^Bd-3/Ser[+] has lethal phenotype

(Hing et al., 1999)

Hsc70-4¹⁹⁵, Ser^Bd-3 has lethal phenotype

(Hing et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ser^Bd-3 has wing blade phenotype, enhanceable by Kap-α3^S033513

(Sachan et al., 2013)

Ser^Bd-3 has wing margin phenotype, enhanceable by Kap-α3^S033513

(Sachan et al., 2013)

Ser^Bd-3 has wing blade phenotype, enhanceable by Kap-α3^D93

(Sachan et al., 2013)

Ser^Bd-3 has wing margin phenotype, enhanceable by Kap-α3^D93

(Sachan et al., 2013)

Ser^Bd-3 has wing blade phenotype, enhanceable by Kap-α3^D165

(Sachan et al., 2013)

Ser^Bd-3 has wing margin phenotype, enhanceable by Kap-α3^D165

(Sachan et al., 2013)

Ser^Bd-3 has phenotype, enhanceable by M285^M285

(Go and Artavanis-Tsakonas, 1998)

Suppressed by

Statement

Reference

Ser^Bd-3/Ser^+r83k has wing phenotype, suppressible | partially by N⁴¹⁴

(Brennan et al., 1999)

Ser^Bd-3/Ser^+r83k has wing phenotype, suppressible | partially by N^l93

(Brennan et al., 1999)

Ser^Bd-3/Ser^+r83k has wing phenotype, suppressible | partially by N^l1N-B

(Brennan et al., 1999)

NOT Enhancer of

Statement

Reference

Ser^Bd-3 is a non-enhancer of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

NOT Suppressor of

Statement

Reference

Ser^Bd-3 is a non-suppressor of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The large nicks in the anterior wing margin observed in Ser^Bd-3 heterozygous adult flies are exacerbated by combination with single copy of any of the following alleles: Kap-α3^D93, Kap-α3^D165 or Kap-α3^S033513 leading to a substantial loss of wing material in the anterior part of the blade.

(Sachan et al., 2013)

The addition of Df(1)N-81k1 or N^Ax-59d has no effect on the Ser^Bd-3/Ser^+r83k wing phenotype. The addition of N^l1N-B, N⁴¹⁴ or N^l93 partially suppresses the phenotype.

(Brennan et al., 1999)

Heterozygous Ser^Bd-3 flies exhibit a wing nicking phenotype. Heterozygous Ser^Bd-3 enhances the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96.

(Helms et al., 1999)

Flies heterozygous for Ser^Bd-3 and Dp(3;3)bxd¹¹⁰ have wing blades that are indistinguishable from those with normal Dl doses.

(Hukriede et al., 1997)

Ser^Bd-3/Ser⁺ wg^l-12/wg⁺ flies raised at 17^oC have wings reduced to a stump.

(Couso et al., 1995)

In combination with N^l93 or Df(1)N-54l9, Ser^Bd-3/Ser^+r83k escapers exhibit phenotypically normal eyes and legs but lack halteres and had wing blades one half normal size.

(Gu et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Ser^Bd-3/Ser^+r83k is rescued by Scer\GAL4^Ser.6.PY/Ser^UAS.cGa

(Yan et al., 2004)

Ser^Bd-3/Ser^+r83k is rescued by Scer\GAL4^Ser.7.PY/Ser^UAS.cGa

(Yan et al., 2004)

Ser^Bd-3/Ser^+r83k is rescued by Ser^UAS.cGa/Scer\GAL4^Ser.5.PY

(Yan et al., 2004)

Partially rescued by

Ser^Bd-3/Ser^+r83k is partially rescued by Ser^UAS.cGa/Scer\GAL4^Ser.3.PY

(Yan et al., 2004)

Not rescued by

Ser^Bd-3/Ser^+r83k is not rescued by Scer\GAL4^Ser.1.PY/Ser^UAS.cGa

(Yan et al., 2004)

Ser^Bd-3/Ser^+r83k is not rescued by Scer\GAL4^Ser.2.PY/Ser^UAS.cGa

(Yan et al., 2004)

Ser^Bd-3/Ser^+r83k is not rescued by Scer\GAL4^Ser.4.PY/Ser^UAS.cGa

(Yan et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

4356

Pri^L Ser^Bd-3/TM6B, Tb¹

Kyoto

107703

Pri^L Ser^Bd-3/TM6B, Tb¹

105916

Ser^Bd-3/In(3R)C, sprd¹ l(3)a¹

Availability

Stated to be lost.

(Goldschmidt, 1944)

Notes on Origin

Discoverer

Goldschmidt, 1934.

(Lindsley and Zimm, 1992)

R.B. Goldschmidt.

(Goldschmidt, 1944)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

Bd-3

(Mukherjee et al., 2006)

Bd³

(Lindsley and Zimm, 1992)

Bd^G

(Brennan et al., 1999, Helms et al., 1999, Hing et al., 1999, Go et al., 1998, Hukriede and Fleming, 1997, Hukriede et al., 1997, Hukriede and Fleming, 1996, Couso et al., 1995, Gu et al., 1995, Lindsley and Zimm, 1992, Thomas et al., 1991, Fleming et al., 1990, Gottschewski, 1935)

BdG

(Haberman et al., 1999)

BgG

(Go and Artavanis-Tsakonas, 1998)

Ser^Bd-3

Ser^Bd-G

(Sachan et al., 2015, Sachan et al., 2013)

Ser^Bd3

(Lebestky et al., 2003)

SerBG

(Griffiths et al., 2007)

Serrate^Bd-3

(Zhu et al., 2017)

Name Synonyms

Beaded of Goldschmidt

(Haberman et al., 2000, Haberman et al., 1998, Hukriede and Fleming, 1997, Lindsley and Zimm, 1992)

Secondary FlyBase IDs

References (27)

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