FB2024_03 , released June 25, 2024
Allele: Dmel\N414
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General Information
Symbol
Dmel\N414
Species
D. melanogaster
Name
FlyBase ID
FBal0066009
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypermorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypermorphic allele - genetic evidence

    (Brennan et al., 1997)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: D1577G. Amino acid replacement: Q1641R. D1577 and Q1641 are in and just after the third lin-12 repeat, respectively.

    (Brennan et al., 1997)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:3,167,358..3,167,358 [+]
    Nucleotide change:

    A3167358G

    Amino acid change:

    D1577G | N-PA; D1577G | N-PB

    Reported amino acid change:

    D1577G

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of two mutations in this strain; other mutation reported as Q1641R but cannot be mapped due to inconsistency between sequences.

    (Brennan et al., 1997)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Hemizygous lethal. Heterozygotes have an antineurogenic phenotype and have a reduced number of thoracic bristles compared to wild-type. The number of thoracic bristles is reduced further in double heterozygous combination with either Dp(1;2)51b.

        (Brennan et al., 1997)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        N414 has visible | dominant phenotype, enhanceable by wgS107

        (Brennan et al., 1997)
        Suppressor of
        Statement
        Reference

        N414 is a suppressor | partially of visible phenotype of SerBd-3/Ser+r83k

        (Brennan et al., 1999)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        N414 has adult thoracic sensillum phenotype, enhanceable by wgS107

        (Brennan et al., 1997)
        Suppressor of
        Statement
        Reference

        N414 is a suppressor | partially of wing phenotype of SerBd-3/Ser+r83k

        (Brennan et al., 1999)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The addition of this allele partially suppresses the vestigial wing phenotype seen in SerBd-3/Ser+r83k flies.

        (Brennan et al., 1999)

        The number of thoracic bristles is reduced further in double heterozygous combination with wgS107.

        (Brennan et al., 1997)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        N414
        Name Synonyms
        Secondary FlyBase IDs
          References (2)