FlyBase Allele Report: Dmel\N[l1N-B]

General Information

Symbol

Dmel\N^l1N-B

Species

D. melanogaster

Name

FlyBase ID

FBal0012886

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

Also Known As

l(1)N^B, l(1)N^β

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

hypomorphic allele - genetic evidence

hypermorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

gain of function allele

(Lyman and Yedvobnick, 1995)

hypermorphic allele - genetic evidence

(Brennan et al., 1997)

hypomorphic allele - genetic evidence

(de Celis et al., 1996)

Mutagen

X ray

(Lyman and Young, 1993, Lindsley and Zimm, 1992)

Progenitor genotype

Cytology

Description

Amino acid replacement: G1573V.

(Ju et al., 2000)

Point mutation in the third lin-12/Notch repeat.

(Brennan et al., 1997)

Amino acid replacement: T1561S. Amino acid replacement: G1572V.

(Lyman and Young, 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:3,167,343..3,167,343 [+]

Nucleotide change:

G3167343T

Amino acid change:

G1572V | N-PA; G1572V | N-PB

Reported amino acid change:

G1573V

Comment:

Position of mutation on reference sequence inferred by FlyBase curator.

(Ju et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult midgut

(de Navascués et al., 2012)

adult thoracic sensillum

(Indrasamy et al., 2000, Brennan et al., 1997)

enteroblast of posterior adult midgut epithelium

(de Navascués et al., 2012)

eye

(Indrasamy et al., 2000, Lindsley and Zimm, 1992, Welshons, 1965)

intestinal stem cell of posterior adult midgut epithelium

(de Navascués et al., 2012)

leg | somatic clone

(de Celis et al., 1998)

macrochaeta

(Lindsley and Zimm, 1992, Welshons, 1965)

macrochaeta & scutum

(Lyman and Yedvobnick, 1995)

macrochaeta | somatic clone

(Arnheim, 1967)

microchaeta & scutum

(Lyman and Yedvobnick, 1995)

orbital bristle

(Indrasamy et al., 2000)

scutum & macrochaeta

sensory mother cell

(Lyman and Yedvobnick, 1995)

thorax

wing | somatic clone

(de Celis et al., 1996)

wing cell | somatic clone

(de Celis et al., 1996)

wing vein | somatic clone

(de Celis et al., 1996)

Detailed Description

Statement

Reference

Midguts from N^l1N-B heterozygotes at 10 days of age show abnormal intestinal stem cell to enteroblast ratio, imbalanced towards the latter.

(de Navascués et al., 2012)

Females have small eye and bald areas on the thorax.

N^l1N-B mutants show significantly reduced mean character size for orbital bristles compared to Canton-S flies.

(Indrasamy et al., 2000)

The formation of proneural clusters are wild-type in N^l1N-B wing discs.

(Brennan et al., 1999)

In homozygous clones in the leg that span a joint, the homozygous cells do not form any joint tissue, although wild-type cells that are in contact with the clone can form joint structures, resulting in incomplete joints. The effect of the N^l1N-B mutation on joint formation appears to be autonomous.

(de Celis et al., 1998)

Heterozygotes have an antineurogenic phenotype and have a reduced number of thoracic bristles compared to wild-type. The number of thoracic bristles is reduced further in double heterozygous combination with Dp(1;2)51b.

(Brennan et al., 1997)

Homozygous clones on the ventral surface of the wing abutting the wing margin cause extensive scalloping, dorsal clones differentiate a normal margin. Mosaic wings also exhibit altered spacing between the veins.

(de Celis et al., 1996)

Suppresses sensory organ precursor specification. Heterozygotes with N^Ax-9 exhibit a T-shaped pattern of mechanosensory bristles on the notum, due to bristle loss. Heterozygotes with a wild type chromosome show mild loss of microchaetae on the mesonotum.

(Lyman and Yedvobnick, 1995)

The dominant bristle effect is more extreme in N^l1N-B/Y;Dp(1;2)51b males than in N^l1N-B/+ females. Heterozygotes with N^fa-1 have fa-like eyes and, frequently, nicked wings; with N^nd-1, they show notched wings and thickened veins; with N^nd-3, they are viable, fertile and fa-like.

(Lindsley and Zimm, 1992)

Male flies carrying Dp(1;2)51bV76e show wing-notching and lateral incisions, leg defects and tarsal reductions, missing or multiple bristles, missing or fused ocelli and variegated or roughened eyes, at varying frequencies.

(Poulson and Lefevre, 1982)

Lethal in combination with N^l1N-ts1 at 29^oC.

(Shellenbarger and Mohler, 1975)

Bristle effect autonomous in N^l1N-B cells; homozygous mutant cells survive in mosaics.

(Arnheim, 1967)

N^l1N-B/Y males die during early larval life.

(Poulson et al., 1967)

N^l1N-B females have small eyes, fewer mesonotal bristles, and, sometimes, bald areas on the thorax.

(Welshons, 1965)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

N^l1N-B has visible | dominant phenotype, enhanceable by wg^S107

(Brennan et al., 1997)

Suppressor of

Statement

Reference

N^l1N-B is a suppressor | partially of visible phenotype of Ser^Bd-3/Ser^+r83k

(Brennan et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

N^l1N-B has adult thoracic sensillum phenotype, enhanceable by wg^S107

(Brennan et al., 1997)

N^l1N-B has phenotype, enhanceable by H¹

(Lyman and Yedvobnick, 1995)

N^l1N-B has microchaeta & scutum phenotype, enhanceable by H¹

(Lyman and Yedvobnick, 1995)

NOT Enhanced by

Statement

Reference

N^l1N-B has phenotype, non-enhanceable by Su(H)²

(Brennan et al., 1999)

Suppressed by

Statement

Reference

N^Ax-9/N^l1N-B has microchaeta phenotype, suppressible by H¹

(Lyman and Yedvobnick, 1995)

NOT suppressed by

Statement

Reference

N^l1N-B has phenotype, non-suppressible by Su(H)²

(Brennan et al., 1999)

Suppressor of

Statement

Reference

N^l1N-B is a suppressor | partially of wing phenotype of Ser^Bd-3/Ser^+r83k

(Brennan et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of Su(H)² has no effect on the proneural clusters in the wing disc in N^l1N-B flies. The addition of N^l1N-B partially suppresses the vestigial wing phenotype seen in Ser^Bd-3/Ser^+r83k flies.

(Brennan et al., 1999)

The number of thoracic bristles is reduced further in double heterozygous combination with wg^S107.

(Brennan et al., 1997)

The loss microchaetae on the mesonotum seen in N^l1N-B/+ flies is enhanced in a H¹/+ background. H^hs.PB largely restores microchaetae specification to a wild type pattern in a N^l1N-B/N^Ax-9 background.

(Lyman and Yedvobnick, 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Abrahamson.

(Lindsley and Zimm, 1992)

Comments

Abolishes the fng-N interaction through Lin-Notch repeats.

(Ju et al., 2000)

Mapped by genetic recombination to between N^spl-1 and N^Co.

(Lyman and Young, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

N^B

(Blair, 2000)

N^l1N-B

l(1)N^B

(de Navascués et al., 2012, Indrasamy et al., 2001, Indrasamy et al., 2000, Ju et al., 2000, Brennan et al., 1999, Brennan et al., 1997, Lyman and Yedvobnick, 1995, Lyman and Young, 1993, Lindsley and Zimm, 1992, Shellenbarger and Mohler, 1975)

l(1)N^β

(de Celis et al., 1998, de Celis et al., 1996)

l^NB

(Poulson and Lefevre, 1982)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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