FB2024_03 , released June 25, 2024
Allele: Dmel\mle5
Open Close
General Information
Symbol
Dmel\mle5
Species
D. melanogaster
Name
FlyBase ID
FBal0012338
Feature type
allele
Associated gene
Dmel\mle
Associated Insertion(s)
Carried in Construct
Also Known As
mleRoma
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Kernan et al., 1991)
Progenitor genotype
Cytology
Description

Deletion in mle.

(Kernan et al., 1991)

2.5kb deletion.

(Kuroda et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      mle5/mle1 is a suppressor of ovary phenotype of ovoD1rv23

      (Oliver and Pauli, 1998)

      mle5/mle1 is a suppressor of germline cell phenotype of ovoD1rv22/ovoD1rv23

      (Oliver et al., 1993)
      Other
      Statement
      Reference

      SxlM1, mle5/mle1, ovoD1rv23 has ovary phenotype

      (Oliver and Pauli, 1998)

      SxlM1, mle5, ovoD1rv23 has ovary phenotype

      (Oliver and Pauli, 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ovaries of homozygous ovoD1rv23 females contain germline chambers in less than 20% of cases. This phenotype is partially suppressed if the females are also carrying mle1/mle5. ovoD1rv23/ovoD1rv23; mle1/mle5 ovaries most often contain germ cells of male morphology rather than female morphology. This phenotype is partially suppressed by SxlM1; ovaries more often contain germ cells of female morphology rather than male morphology.

      (Oliver and Pauli, 1998)

      The survival of 2X ovoD1rv23/ovoD1rv22 germline cells is enhanced in an mle1/mle5 background. Surviving cells usually form small ovarian tumours.

      (Oliver et al., 1993)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Mutant phenotype can be rescued by P element mediated transformation of a wild type mle gene copy.

      (Kernan et al., 1991)

      Allelism inferred from map position at 2-55.2.

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mle5
      mleRoma
      (Oliver et al., 1993, Kernan et al., 1991, Kuroda et al., 1991)
      mll
      Name Synonyms
      Secondary FlyBase IDs
        References (5)