FlyBase Allele Report: Dmel\fray[07551]

General Information

Symbol

Dmel\fray⁰⁷⁵⁵¹

Species

D. melanogaster

Name

FlyBase ID

FBal0009600

Feature type

allele

Associated gene

Dmel\fray

Associated Insertion(s)

P{PZ}fray⁰⁷⁵⁵¹

Carried in Construct

Also Known As

l(3)07551

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Leiserson et al., 2000, Spradling et al., 1999, Maixner et al., 1998, Petitt, 1998.3.3, Russell et al., 1998, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{PZ}fray⁰⁷⁵⁵¹

Cytology

Description

The P{PZ} insertion in the first intron of fray in the 5' UTR.

(Leiserson et al., 2000)

The P{PZ}fray⁰⁷⁵⁵¹ insertion maps within both fray and CG7694 (transcription units with non-overlapping ORFs which share untranslated sequences).

(FlyBase, 1996-)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:18,585,629..18,585,629 [+]

(Ryder and Roote, 2004.11.10, Leiserson et al., 2000, Spradling et al., 1999, Maixner et al., 1998, Petitt, 1998.3.3, Russell et al., 1998, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | maternal effect

(Perrimon et al., 1996)

lethal | larval stage | recessive

(Perrimon et al., 1996)

lethal | recessive

(Spradling et al., 1999)

lethal - all die before end of larval stage | recessive

(Russell et al., 1998)

some die during larval stage | recessive

(Russell et al., 1998)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Russell et al., 1998)

embryonic/first instar larval cuticle | maternal effect

(Perrimon et al., 1996)

embryonic/larval peripheral nervous system

(Leiserson et al., 2000)

Detailed Description

Statement

Reference

The segmental nerves exhibit a frayed nerve phenotype - localised bulging and swellings are seen i the nerve. Defects range from mild bulging to immense bulges that exceed 300μm in length and 50μm in diameter.

(Leiserson et al., 2000)

Homozygotes die during the second larval instar stage. Embryos derived from homozygous female germ line clones show poor cuticle development.

(Russell et al., 1998)

Germline clones produce eggs with poor cuticle development.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

fray[+]/fray⁰⁷⁵⁵¹ is a suppressor of visible phenotype of Scer\GAL4^hh.PU, Wnk^EY10165

(Sato and Shibuya, 2013)

fray⁰⁷⁵⁵¹ is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Other

Statement

Reference

Ras85D^V12.sev, fray⁰⁷⁵⁵¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Suppressor of

Statement

Reference

fray[+]/fray⁰⁷⁵⁵¹ is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^hh.PU, Wnk^EY10165

(Sato and Shibuya, 2013)

fray[+]/fray⁰⁷⁵⁵¹ is a suppressor of wing vein L4 phenotype of Scer\GAL4^hh.PU, Wnk^EY10165

(Sato and Shibuya, 2013)

Additional Comments

Genetic Interactions

Statement

Reference

fray⁰⁷⁵⁵¹/+ partially suppresses the penetrance of the wing phenotypes (additional veins around vein 5 and delta phenotypes at vein 4) caused by expression of Wnk^EY10165 under the control of Scer\GAL4^hh.PU.

(Sato and Shibuya, 2013)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by fray⁰⁷⁵⁵¹.

(Maixner et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

fray^s2427

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11721

ry⁵⁰⁶ P{PZ}fray⁰⁷⁵⁵¹ CG7694⁰⁷⁵⁵¹/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

FlyBase curator comment: Lethality described may be due to disruption of fray or overlapping CG7694 - both disrupted by FBti0005585.

(Ryder and Roote, 2004.11.10)

Complements: l(3)08126⁰⁸¹²⁶. Complements: l(3)08126^j2B3.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

fray⁰⁷⁵⁵¹

(Sato and Shibuya, 2013, Christensen et al., 2008.4.15)

fray^PZ07551

(Pueyo et al., 2016)

fray^PZ

(Pueyo et al., 2016)

l(3)07551

(Spradling et al., 1999, Maixner et al., 1998, Russell et al., 1998)

l(3)07551⁰⁷⁵⁵¹

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

Open Close