FlyBase Allele Report: Dmel\wor[4]

General Information

Symbol

Dmel\wor⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0008519

Feature type

allele

Associated gene

Dmel\wor

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ashburner et al., 1999.10.12)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage 11 (with Df(2L)ED1054)

(Arefin et al., 2019)

decreased cell number | embryonic stage 11 (with Df(2L)ED1054)

(Arefin et al., 2019)

decreased cell number | embryonic stage 13 (with Df(2L)ED1054)

(Bahrampour et al., 2017)

decreased cell number | embryonic stage 14 (with Df(2L)ED1054)

(Bahrampour et al., 2017)

decreased occurrence of cell division | embryonic stage 13 (with Df(2L)ED1054)

(Bahrampour et al., 2017)

decreased occurrence of cell division | embryonic stage 14 (with Df(2L)ED1054)

(Bahrampour et al., 2017)

lethal (with Df(2L)do1)

(Ashraf et al., 2004)

lethal (with Df(2L)osp29)

(Ashraf et al., 2004)

lethal - all die during embryonic stage | recessive

(Ashburner et al., 1990)

partially lethal - majority die (with wor¹)

(Ashraf et al., 2004)

partially lethal - majority die (with wor³)

(Ashraf et al., 2004)

partially lethal - majority die | recessive

(Ashraf et al., 2004)

some die during embryonic stage | recessive

(Ashburner et al., 1990)

Phenotype Manifest In

embryonic ganglion mother cell | embryonic stage 14 (with Df(2L)ED1054)

(Bahrampour et al., 2017)

embryonic neuroblast | embryonic stage 11 (with Df(2L)ED1054)

(Arefin et al., 2019)

embryonic neuroblast | embryonic stage 13 (with Df(2L)ED1054)

(Bahrampour et al., 2017)

embryonic neuroblast | embryonic stage 14 (with Df(2L)ED1054)

(Bahrampour et al., 2017)

Detailed Description

Statement

Reference

wor⁴/Df(2L)ED1054 stage 11 mutants exhibit reduced neuroblast numbers when compared to control embryos.

(Arefin et al., 2019)

wor⁴/Df(2L)ED1054 transheterozygotes present a significant decrease in the number of dividing neuroblasts during stages 13 and 14 of embryogenesis and a significant decrease in the number of dividing neuroblast daughters during stage 14, but not stage 13, of embryogenesis, as compared to controls; there is a significantly decreased neuroblast number at both embryonic stages, as compared to controls. These mutants do not show defects in neuroblast in lineage progression at stage 17 embryos, as compared to controls.

(Bahrampour et al., 2017)

4% of homozygous embryos hatch (this lethality may be attributed partly to additional mutations on the wor⁴ chromosome). 57% of wor¹/wor⁴ embryos hatch. 38% of wor¹/wor⁴ animals survive to adulthood. 84% of wor³/wor⁴ embryos hatch. 17% of wor³/wor⁴ animals survive to adulthood. wor⁴/Df(2L)do1 embryos do not hatch. wor⁴/Df(2L)osp29 animals do not survive to adulthood.

(Ashraf et al., 2004)

Larval denticle belt polarity disrupted.

(Ashburner et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

wor⁴/Df(2L)ED1054 has decreased occurrence of cell division | embryonic stage 14 phenotype, suppressible by Scer\GAL4^elav-C155/CycE^UAS.cLa

(Bahrampour et al., 2017)

Other

Statement

Reference

CycE^AR95/CycE[+], Df(3R)Exel6186, Df(3R)Exel6212/+, wor⁴ has decreased cell number | embryonic stage 17 phenotype

(Bahrampour et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

wor⁴/Df(2L)ED1054 has embryonic neuroblast | embryonic stage 14 phenotype, suppressible by Scer\GAL4^elav-C155/CycE^UAS.cLa

(Bahrampour et al., 2017)

wor⁴/Df(2L)ED1054 has embryonic ganglion mother cell | embryonic stage 14 phenotype, suppressible by Scer\GAL4^elav-C155/CycE^UAS.cLa

(Bahrampour et al., 2017)

Other

Statement

Reference

CycE^AR95/CycE[+], Df(3R)Exel6186, Df(3R)Exel6212/+, wor⁴ has thoracic neuroblast NB5-6 | embryonic stage 17 phenotype

(Bahrampour et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Df(1)BSC530 wor (wor⁴/Df(2L)ED1054) stage 11 double mutants display a near-complete loss of neuroblasts, below the numbers observed in each single mutant when compared to control embryos.

(Arefin et al., 2019)

The decreased neuroblast/neuroblast daughter divisions observed in wor⁴/Df(2L)ED1054 transheterozygous stage 14 embryos is suppressed by the expression of CycE^Scer\UAS.cLa under the control of Scer\GAL4^elav-C155.

wor⁴/+, CycE^AR95/+, Df(3R)Exel6186/+, Df(3R)Exel6212/+ quadruple heterozygous stage 17 (air-filled trachea) embryos show defects in neuroblast in lineage progression, as illustrated by the frequent loss of the last-born cell in the NB5-6T lineage, as compared to controls.

(Bahrampour et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

wor⁴/wor³ is rescued by wor^+t13

(Ashraf et al., 2004)

wor⁴/wor¹ is rescued by wor^+t13

(Ashraf et al., 2004)

Df(2L)osp29/wor⁴ is rescued by wor^+t13

(Ashraf et al., 2004)

Partially rescued by

wor⁴/wor¹ is partially rescued by wor^hs.PA

(Ashraf et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25170

wor⁴ cn¹ bw¹ speck¹/CyO

Notes on Origin

Discoverer

Simpson.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

B27

l(2)35Da⁴

(Ashburner et al., 1999.10.12)

l(2)35Da^B27

(Ashraf et al., 2004)

l(2)^B27

(Ashburner et al., 1990)

wor⁴

(Arefin et al., 2019, Bahrampour et al., 2019, Bahrampour et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close