FB2024_03 , released June 25, 2024
Allele: Dmel\wor1
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General Information
Symbol
Dmel\wor1
Species
D. melanogaster
Name
FlyBase ID
FBal0008516
Feature type
allele
Associated gene
Dmel\wor
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)br35HG35
Key Links
Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Ashraf et al., 2004)

loss of function allele

(Parrish et al., 2006)
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Grau et al., 1984)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The class I da neurons of sna18 mutants show dorsal overextension of primary dendrites as well as a modest reduction in lateral branching.

      (Parrish et al., 2006)

      94% of homozygous embryos hatch. Most homozygotes die as second instar larvae (although this may be due to other mutations on the wor1 chromosome). 100% of wor1/wor3 embryos hatch. 32% of wor1/wor3 animals survive to adulthood. 57% of wor1/wor4 embryos hatch. 38% of wor1/wor4 animals survive to adulthood. 21% of wor1/Df(2L)osp29 embryos hatch. None of these animals survive to adulthood. 10% of wor1/Df(2L)do1 embryos hatch. Homozygous second instar larvae have longer brainstems than control larvae and the morphology of the mutant brain hemisphere is less well-defined than that of controls. wor1/wor3 larvae have longer brainstems than control larvae.

      (Ashraf et al., 2004)

      Larval denticle belt polarity disrupted.

      (Ashburner et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      wor[+]/wor1 is a non-enhancer of visible | dominant phenotype of gcmPyx

      (Popkova et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      wor[+]/wor1 is a non-suppressor of visible | dominant phenotype of gcmPyx

      (Popkova et al., 2012)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      wor[+]/wor1 is a non-enhancer of chaeta | increased number phenotype of gcmPyx

      (Popkova et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      wor[+]/wor1 is a non-suppressor of chaeta | increased number phenotype of gcmPyx

      (Popkova et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      wor3/wor1 is rescued by wor+t13

      (Ashraf et al., 2004)

      wor4/wor1 is rescued by wor+t13

      (Ashraf et al., 2004)

      Df(2L)osp29/wor1 is rescued by wor+t13

      (Ashraf et al., 2004)
      Partially rescued by

      wor3/wor1 is partially rescued by worhs.PA

      (Ashraf et al., 2004)

      wor4/wor1 is partially rescued by worhs.PA

      (Ashraf et al., 2004)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Harrington.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      References (14)