FB2024_03 , released June 25, 2024
Allele: Dmel\Fkbp1400734
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General Information
Symbol
Dmel\Fkbp1400734
Species
D. melanogaster
Name
FlyBase ID
FBal0007956
Feature type
allele
Associated gene
Dmel\Fkbp14
Associated Insertion(s)
P{PZ}Fkbp1400734
Carried in Construct
Also Known As
l(2)00734, Fkbp13P962
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}Fkbp1400734
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  muscular dystrophy
      modeled by Dg323
      (Kucherenko et al., 2011)
      modeled by DgO86
      (Kucherenko et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      FlyBase curator comment: Interactions with Dg[086] and/or Dg[323] were detected in a Dg[086]/+ or Dg[323]/+ background which exhibits no obvious changes in muscle morphology. Nonetheless, these interactions have been captured as 'modifier' ('exacerbates') annotations here to best capture the experimental finding and the authors' intention.

      (Kucherenko et al., 2011)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fkbp1400734/+ mutant flies do not exhibit temperature-induced mobility defects.

      (Kucherenko et al., 2011)

      Fkbp1300734 mutants display ISNb bypass at a similar rate to wild-type embryos.

      (Fox and Zinn, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Fkbp14[+]/Fkbp1400734 is a non-enhancer of indirect flight muscle cell phenotype of DysRNAi.NH2.UAS, Scer\GAL4Act.PU

      (Kucherenko et al., 2011)

      Fkbp14[+]/Fkbp1400734 is a non-enhancer of indirect flight muscle cell phenotype of DgRNAi.UAS, Scer\GAL4Act.PU

      (Kucherenko et al., 2011)

      Fkbp1400734 is a non-enhancer of anterior fascicle & axon | ectopic phenotype of Larbypass

      (Fox and Zinn, 2005)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Fkbp14 Dys double heterozygous flies (Fkbp1400734/Df(3R)Exel6184) do not exhibit indirect flight muscle degeneration.

      Fkbp1400734 DgO86 double heterozygous flies exhibit indirect flight muscle degeneration.

      One copy of Fkbp1400734 does not enhance the indirect flight muscle degeneration seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU.

      One copy of Fkbp1400734 does not enhance the indirect flight muscle degeneration seen when DgdsRNA.Scer\UAS is expressed under the control of Scer\GAL4tub.PU.

      Fkbp1400734 Dg323 double heterozygous flies exhibit indirect flight muscle degeneration.

      (Kucherenko et al., 2011)

      The Fkbp1300734 mutation does not increase the frequency of the Larbypass ISNb bypass phenotype.

      (Fox and Zinn, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Reversion analysis proved that the P{PZ} is responsible for the lethal phenotype.

      (Beaton, 2000.1.31)

      Complements: MESK201467. Complements: l(2)0360503605. Complements: MESK208827. Complements: MESK208882. Complements: Sdc10608. Complements: l(2)k10317k10317.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      FKBP13PZ00734
      (Bokel et al., 2006)
      Fkbp1300734
      Fkbp13P962
      (Kucherenko et al., 2011, Marrone et al., 2011)
      Fkbp1400734
      fkbp13M34
      (Fox and Zinn, 2005)
      l(2)00734
      (Johnson et al., 2004, Spradling et al., 1999)
      l(2)0073400734
      (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)