FlyBase Allele Report: Dmel\lawc[EF520]

General Information

Symbol

Dmel\lawc^EF520

Species

D. melanogaster

Name

FlyBase ID

FBal0007308

Feature type

allele

Associated gene

Dmel\lawc

Associated Insertion(s)

Carried in Construct

Also Known As

l(1)EF520

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Zorin et al., 1999)

Mutagen

ethyl methanesulfonate

(Zorin et al., 1999)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

cell lethal | germline clone

(Perrimon et al., 1989)

lethal

lethal | recessive

(Perrimon et al., 1989)

lethal - all die before end of larval stage | recessive

(Zorin et al., 1999)

some die during larval stage | recessive

(Zorin et al., 1999)

Phenotype Manifest In

arista

(Zorin et al., 1999)

Detailed Description

Statement

Reference

lawc^EF520 causes early larval lethality. The 3% of lawc^EF520/lawc^p1 females that eclose have a lawc mutant phenotype including arista to leg transformation.

(Zorin et al., 1999)

Lethal phase is during the embryonic to larval stages.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

lawc[+]/lawc^EF520 is an enhancer of visible | dominant | homeotic phenotype of brm², trx[+]/trx^E2

(Zorin et al., 1999)

lawc[+]/lawc^EF520 is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Zorin et al., 1999)

lawc[+]/lawc^EF520 is an enhancer of visible | dominant | homeotic phenotype of ash1[+]/ash1¹⁷, trx^B11

(Zorin et al., 1999)

lawc^EF520 is an enhancer of visible | homeotic phenotype of ash1¹⁷, trx^B11

(Zorin et al., 1999)

lawc[+]/lawc^EF520 is an enhancer of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Zorin et al., 1999)

NOT Enhancer of

Statement

Reference

lawc^EF520 is a non-enhancer of visible | dominant | homeotic phenotype of brm²

(Zorin et al., 1999)

lawc^EF520 is a non-enhancer of visible | dominant | homeotic phenotype of trx^B11

(Zorin et al., 1999)

lawc^EF520 is a non-enhancer of visible | dominant | homeotic phenotype of ash1¹⁷

(Zorin et al., 1999)

Other

Statement

Reference

ash1¹⁷, lawc^p1/lawc^EF520 has lethal phenotype

(Zorin et al., 1999)

brm², lawc^p1/lawc^EF520 has lethal phenotype

(Zorin et al., 1999)

lawc^p1/lawc^EF520, trx^B11 has lethal phenotype

(Zorin et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

lawc[+]/lawc^EF520 is an enhancer of haltere phenotype of ash1¹⁷, trx^B11/trx[+]

(Zorin et al., 1999)

lawc^EF520 is an enhancer of metathoracic leg phenotype of ash1¹⁷, trx^B11

(Zorin et al., 1999)

NOT Enhancer of

Statement

Reference

lawc^EF520 is a non-enhancer of eye phenotype of CycE^JP

(Brumby et al., 2002)

NOT Suppressor of

Statement

Reference

lawc^EF520 is a non-suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Does not enhance the frequency of homeotic transformations of trx^B11, brm² or ash1¹⁷ single heterozygotes. The frequency of homeotic transformations in trx^B11 ash1¹⁷ or brm² trx^E2 double heterozygotes is dominantly enhanced by lawc^EF520. lawc^p1/lawc^EF520 females are viable. However, in combination with trx^B11, brm² or ash1¹⁷, lawc^p1/lawc^EF520 results in lethality. lawc^p1/Df(1)RA2 females are viable. However, in combination with trx^B11, brm² or ash1¹⁷, lawc^p1/Df(1)RA2 results in lethality.

(Zorin et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Nrg^ibx

(Carhan et al., 2005)

Comments

The reduced female receptivity phenotype of Nrg^ibx is complemented by lawc^EF520.

(Carhan et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (2)

4682

107835

Notes on Origin

Discoverer

Lefevre.

Comments

Maternal germline clonal analysis demonstrates cell lethality in homozygous clones.

(Perrimon et al., 1989)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

EF520

(Perrimon et al., 1989)

l(1)520

(Simonova, 2002.8.21)

l(1)7Ea⁵

l(1)EF520

(Cherezov et al., 2020, Simonova et al., 1999, Simonova et al., 1999, Zorin et al., 1999, Simonova et al., 1998)

lawc^EF520

(Carhan et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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