FB2024_03 , released June 25, 2024
Allele: Dmel\hd1
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General Information
Symbol
Dmel\hd1
Species
D. melanogaster
Name
FlyBase ID
FBal0004710
Feature type
allele
Associated gene
Dmel\hd
Associated Insertion(s)
Carried in Construct
Also Known As
hd272-9
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Bandura, 2005)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: G463D.

(Bandura et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:5,372,994..5,372,994 [-]
Nucleotide change:

G5372994A

Amino acid change:

G463D | hd-PA; G463D | hd-PB

Reported amino acid change:

G463D

Comment:

Site of nucleic acid difference inferred by FlyBase based on reported amino acid change

(Bandura et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  syndrome
      CEA
      (Lesly et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females homozygous for hd1 or transheterozygous for hd1/Df(3R)3-4 produce eggs with severely thin shells that dehydrate and collapse after they are laid.

      Embryos from transheterozygous hd1/Df(3R)3-4 females arrest during the first few nuclear cleavage cycles.

      Embryos from transheterozygous hd1/Df(3R)3-4 females expressing hdUAS.cBa under the control of Scer\GAL4c323 arrest during the first few nuclear cleavage cycles and have chromatin and centrosome abnormalities such as: chromatin bridges between nuclei, misshaped or multipolar spindles and an excess of centrosomes, either freed from the mitotic spindle or accumulated at spindle poles.

      Early cleavage divisions in embryos homozygous for hdEGFP in a hd1/Df(3R)3-4 background appear normal, with mitotic defects becoming apparent during embryonic cycles 8/9.

      (Lesly et al., 2017)

      hd1 and hd1/Df(3R)3-4 females lay eggs with thin shells that do not hatch. BrdU incorporation shows that hd1 follicle cell nuclei have a severe defect in amplification.

      (Bandura et al., 2005)

      Egg shells produced by homozygous females extremely disrupted. Deficiency of endochorionic material. All six chorion proteins and their mRNA's present at reduced levels; deficiency in the level of chorion-gene amplification in follicle cells.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      hd1/Df(3R)3-4, Scer\GAL4c323, hdUAS.cBa has chromosome | maternal effect | cleavage stage phenotype, non-suppressible by plu3/plu3

      (Lesly et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      hd1 is rescued by hdUAS.cBa/Scer\GAL4da.G32

      (Bandura, 2005)

      hd1/Df(3R)3-4 is rescued by hdUAS.cBa/Scer\GAL4c323

      (Bandura, 2005)
      Partially rescued by

      hd1/Df(3R)3-4 is partially rescued by hdEGFP

      (Lesly et al., 2017)

      hd1/Df(3R)3-4 is partially rescued by hdUAS.cBa/Scer\GAL4c323

      (Lesly et al., 2017)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Nusslein-Volhard.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      fs(3)272-9
      (Bandura et al., 2005)
      fs(3)272-91
      hd1
      hd272-9
      (Lesly et al., 2017, Bandura, 2005, Bandura et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)