FB2024_03 , released June 25, 2024
Allele: Dmel\hdUAS.cBa
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General Information
Symbol
Dmel\hdUAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Bandura
FlyBase ID
FBal0191504
Feature type
allele
Associated gene
Dmel\hd
Associated Insertion(s)
Carried in Construct
P{UAS-hd.B}
Key Links
Transgenic product class
cDNA
(Bandura, 2005)
wild_type
(Bandura, 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Bandura, 2005)
wild_type
(Bandura, 2005)
Mutagen
in vitro construct
(Bandura, 2005, Bandura et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-hd.B}
Cytology
Description

UASt sequences drive expression of the entire coding region of the hd gene (corresponding to cDNA clone RE04029).

(Bandura, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
hd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos from transheterozygous hd1/Df(3R)3-4 females expressing hdUAS.cBa under the control of Scer\GAL4c323 arrest during the first few nuclear cleavage cycles and have chromatin and centrosome abnormalities such as: chromatin bridges between nuclei, misshaped or multipolar spindles and an excess of centrosomes, either freed from the mitotic spindle or accumulated at spindle poles.

      (Lesly et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      hd1/Df(3R)3-4, Scer\GAL4c323, hdUAS.cBa has chromosome | maternal effect | cleavage stage phenotype, non-suppressible by plu3/plu3

      (Lesly et al., 2017)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      hdUAS.cBa/Scer\GAL4da.G32 rescues hd1

      (Bandura, 2005)

      hdUAS.cBa/Scer\GAL4c323 rescues hd1/Df(3R)3-4

      (Bandura, 2005)
      Partially rescues

      hdUAS.cBa/Scer\GAL4c323 partially rescues hd1/Df(3R)3-4

      (Lesly et al., 2017)
      Comments

      Expressing hdUAS.cBa under the control of Scer\GAL4c323 rescues eggshell synthesis in embryos from transheterozygous hd1/Df(3R)3-4 females, but fails to rescue embryo lethality.

      (Lesly et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      hdScer\UAS.cBa
      hdUAS.cBa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Bandura
      (Bandura, 2005)
      Secondary FlyBase IDs
        References (3)