FB2024_03 , released June 25, 2024
Allele: Dmel\esg35Ce-1
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General Information
Symbol
Dmel\esg35Ce-1
Species
D. melanogaster
Name
FlyBase ID
FBal0003842
Feature type
allele
Associated gene
Dmel\esg
Associated Insertion(s)
Carried in Construct
Also Known As
esgVS2
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Samakovlis et al., 1996)
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Samakovlis et al., 1996, Roote, 1995.5.4, Hayashi et al., 1993)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      esg05729/esg35Ce-1 pharate pupae have well-differentiated testes. The stem cells and spermatogenic cells that are normally found at the tip of the testis are missing in the mutants, with the mutant testes containing only sperm bundles and motile sperm.

      (Streit et al., 2002)

      The dorsal branch fusion cells form discrete branches that never meet or join. These cells go on to form additional branches that resemble normal terminal branches in the larva. Lateral trunk fusion branches are completely missing leaving a gap in each segment of the lateral trunk.

      (Samakovlis et al., 1996)

      Many heteroallelic combinations studied. Where flies die as pharate adults sternite/tergites partially or completely deleted and/or legs are twisted. Where flies are viable, they have held out wings, and may have twisted legs, sternite/tergites partially deleted and be sickly. Abdominal histoblasts examined in heteroallelic combinations and found to have nuclei 3.4 fold times larger (revealed by Ecol\lacZ expression from esg05729 allele) and with 7-16 times as much DNA (DAPI fluorescence) as wild type histoblast nuclei.

      (Hayashi et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      esg35Ce-1/esg[+] is a suppressor of visible | dominant phenotype of gcmPyx

      (Popkova et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      esg35Ce-1/esg[+] is a non-suppressor of bang sensitive phenotype of parabss1

      (Hekmat-Scafe et al., 2005)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      esg35Ce-1/esg[+] is a suppressor of chaeta | increased number phenotype of gcmPyx

      (Popkova et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      eas2/+ ; esg35Ce-1/+ double heterozygous females show no bang sensitivity. The bang sensitivity of bss1/+ flies is not significantly altered by esg35Ce-1/+.

      (Hekmat-Scafe et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Simpson.

      P. Simpson.

      (Roote, 1995.5.4)

      Induced on: l(2)CA61VS.

      (Roote, 2005.7.11, Roote, 1997.8.13)
      Comments
      Comments

      Phenotypic data included in FBrf0051973.

      (Roote, 1995.5.4)

      Strong esg allele.

      (Samakovlis et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (8)
      References (18)