FlyBase Allele Report: Dmel\Delta[X]

General Information

Symbol

Dmel\Delta^X

Species

D. melanogaster

Name

extreme

FlyBase ID

FBal0002638

Feature type

allele

Associated gene

Dmel\Delta

Associated Insertion(s)

Carried in Construct

Also Known As

Dl^x

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Lieber et al., 1993, Abmayr et al., 1992)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Thumm and Kadowaki, 2001)

Phenotype Manifest In

dMP2 neuron | ectopic | germline clone

(Rusconi and Corbin, 1999)

dorsal acute muscle cell | ectopic

(Carmena et al., 2002)

dorsal acute muscle cell | ectopic | precursor

(Carmena et al., 2002)

embryonic/larval somatic muscle cell

(Rusconi and Corbin, 1998)

embryonic/larval somatic muscle cell | germline clone

(Rusconi and Corbin, 1998)

larval RP2 motor neuron | ectopic | germline clone

(Rusconi and Corbin, 1999)

pericardial cell | ectopic

(Carmena et al., 2002)

pericardial cell | ectopic | precursor

(Carmena et al., 2002)

rhabdomere

(Ma et al., 1996)

RP2sib neuron | germline clone

(Rusconi and Corbin, 1999)

U neuron | ectopic | germline clone

(Rusconi and Corbin, 1999)

Usib neuron | germline clone

(Rusconi and Corbin, 1999)

vMP2 neuron | ectopic | germline clone

(Rusconi and Corbin, 1999)

wing vein

(Thumm and Kadowaki, 2001)

wing vein L2

(Thumm and Kadowaki, 2001)

Detailed Description

Statement

Reference

Extra EPCs (eve-positive heart associated or pericardial cells) and DA1 founders (and subsequently muscles) are seen in most hemisegments of mutant embryos.

(Carmena et al., 2002)

Heterozygotes show wing vein thickenings of L2 and terminal deltas.

(Thumm and Kadowaki, 2001)

The number of ftz expressing MP2 neurons increases compared to wild-type (About 15 on each side of the midline, as compared to 2 in wild-type) in homozygous embryos derived from homozygous female germ-line clones (lacking both maternal and zygotic function). In homozygous embryos derived from homozygous female germ-line clones (lacking both maternal and zygotic function), RP2sib neurons become eve expressing RP2 neurons. Occasionally a third RP2-like cell is observed. Usib neurons also appear to become U neurons.

(Rusconi and Corbin, 1999)

The number of cells in the nau-expressing muscle precursor clusters is increased compared to wild-type in homozygous embryos and in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function).

(Rusconi and Corbin, 1998)

Homozygotes exhibit ommatidia containing an increased number of rhabdomere-bearing cells.

(Ma et al., 1996)

Extreme neurogenic phenotype.

(Lieber et al., 1993)

Dl^X shows severe neural hypertrophy, a 6--9 fold increase in nau expressing cells per cluster relative to wild type. Clusters of βTub85D producing cells also enlarge and merge together but they cannot assume correct morphology as they don't fuse properly, they are also displaced. In addition Mhc protein is highly expressed and the Mhc expressing cells are arranged in irregular clusters.

(Corbin et al., 1991)

RK2.

(Craymer, 1980)

extreme allele

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Delta^X has visible | dominant phenotype, enhanceable by CG6194[+]/Atg4b^P0997

(Thumm and Kadowaki, 2001)

Enhancer of

Statement

Reference

Dl[+]/Delta^X is an enhancer of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

Delta^X has dorsal acute muscle cell | precursor | ectopic phenotype, enhanceable by aos^Δ7

(Carmena et al., 2002)

Delta^X has pericardial cell | ectopic phenotype, enhanceable by aos^Δ7

(Carmena et al., 2002)

Delta^X has pericardial cell | precursor | ectopic phenotype, enhanceable by aos^Δ7

(Carmena et al., 2002)

Delta^X has dorsal acute muscle cell | ectopic phenotype, enhanceable by aos^Δ7

(Carmena et al., 2002)

Delta^X has wing vein L2 phenotype, enhanceable by CG6194[+]/Atg4b^P0997

(Thumm and Kadowaki, 2001)

Delta^X has wing vein phenotype, enhanceable by CG6194[+]/Atg4b^P0997

(Thumm and Kadowaki, 2001)

Enhancer of

Statement

Reference

Dl[+]/Delta^X is an enhancer of eye phenotype of Scer\GAL4^ey.PH, fng^UAS.cKa

(Dominguez et al., 2004)

Dl[+]/Delta^X is an enhancer of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Delta^X is an enhancer of dorsal acute muscle cell | precursor | ectopic phenotype of aos^Δ7

(Carmena et al., 2002)

Delta^X is an enhancer of pericardial cell | ectopic phenotype of aos^Δ7

(Carmena et al., 2002)

Delta^X is an enhancer of pericardial cell | precursor | ectopic phenotype of aos^Δ7

(Carmena et al., 2002)

Delta^X is an enhancer of dorsal acute muscle cell | ectopic phenotype of aos^Δ7

(Carmena et al., 2002)

Suppressor of

Statement

Reference

Delta^X is a suppressor of dorsal oblique muscle cell phenotype of Egfr^DN.UAS, Scer\GAL4^twi.PB

(Carmena et al., 2002)

Delta^X is a suppressor of pericardial cell phenotype of Egfr^DN.UAS, Scer\GAL4^twi.PB

(Carmena et al., 2002)

Delta^X is a suppressor | partially of presumptive embryonic/larval central nervous system phenotype of N^{ΔLNR.lexA.UAS}, Scer\GAL4^da.G32

(Lieber et al., 2002)

Delta^X is a suppressor | partially of presumptive embryonic/larval central nervous system phenotype of N^{ΔLN.lexA.UAS}, Scer\GAL4^da.G32

(Lieber et al., 2002)

NOT Suppressor of

Statement

Reference

Delta^X is a non-suppressor of presumptive embryonic/larval central nervous system phenotype of N^{Intra1790.lexA.UAS}, Scer\GAL4^da.G32

(Lieber et al., 2002)

Other

Statement

Reference

Delta^X, stl[+]/stl⁴ has ovariole phenotype

(Ozdowski et al., 2009)

Delta^X, aos^Δ7 has dorsal oblique muscle cell | ectopic phenotype

(Carmena et al., 2002)

Delta^X, aos^Δ7 has dorsal oblique muscle cell | precursor | ectopic phenotype

(Carmena et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

58.3% of stl⁴/+ ; Dl^X/+ ovarioles have compound or morphologically disrupted follicles.

(Ozdowski et al., 2009)

One copy of Dl^X enhances the small eye phenotype of flies in which fng^Scer\UAS.cKa is expressed under the control of Scer\GAL4^ey.PH.

(Dominguez et al., 2004)

The EPC and DA1 phenotype seen in argos^Δ7 and Dl^X exhibit a synergistic effect on each other when combined. An increase in the number of DO2 muscles is also seen.

(Carmena et al., 2002)

The wing vein thickenings of L2 and terminal deltas seen in Dl^X/+ flies is enhanced by CG6194^P0997/+.

(Thumm and Kadowaki, 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

4209

Delta^X/In(3L)P, In(3R)P

60336

Delta^X/TM3, Sb¹

Kyoto

107632

Delta^X/In(3L)P, In(3R)P

Notes on Origin

Discoverer

Stern, 1932.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Delta^X

(Michaud and Tanguay, 2003)

Dl^X

(Ozdowski et al., 2009, Estrada et al., 2007, Estrada et al., 2006)

Dl^x

(Kidd and Lieber, 2002, Lieber et al., 2002, Thumm and Kadowaki, 2001, Wesley and Saez, 2000, Kidd et al., 1998, Lord et al., 1995)

Name Synonyms

extreme

(Craymer, 1980)

Secondary FlyBase IDs

References (28)

Report Sections

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