FlyBase Allele Report: Dmel\brm[1]

General Information

Symbol

Dmel\brm¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001295

Feature type

allele

Associated gene

Dmel\brm

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Elfring et al., 1998)

Mutagen

ethyl methanesulfonate

(Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Elfring et al., 1998, Brizuela et al., 1994, Kennison and Tamkun, 1988)

Phenotype Manifest In

Detailed Description

Statement

Reference

brm¹/brm¹⁶ heterozygous females have greatly reduced fertility.

(Brizuela et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

brm¹ is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

brm¹/brm[+] is a suppressor of visible | homeotic phenotype of Antp^Ns, Pc²

(Kennison and Tamkun, 1988)

Other

Statement

Reference

Hcf^HR1, brm¹/brm[+] has visible phenotype

(Rodriguez-Jato et al., 2011)

γTub23C^Pl-2, brm¹ has visible | dominant phenotype

(Vázquez et al., 2008)

Ras85D^V12.sev, brm¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Suppressor of

Statement

Reference

brm¹/brm[+] is a suppressor of eye phenotype of Scer\GAL4^ey.PH, asf1^UAS.cMa

(Moshkin et al., 2002)

brm¹/brm[+] is a suppressor of antenna phenotype of Antp^Ns, Pc²

(Kennison and Tamkun, 1988)

Other

Statement

Reference

Hcf^HR1, brm¹/brm[+] has leg phenotype

(Rodriguez-Jato et al., 2011)

γTub23C^Pl-2, brm¹ has wing phenotype

(Vázquez et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Hcf^HR1 shows leg defects when in double heterozygous combination with brm¹ (20% penetrance).

(Rodriguez-Jato et al., 2011)

γTub23C^Pl-2 results in a held-out wing phenotype in double heterozygous combination with brm¹ (35% penetrance).

(Vázquez et al., 2008)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by brm¹.

(Maixner et al., 1998)

Suppresses the antenna to leg transformation phenotype of Pc², Antp^Ns/+. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

brm¹ is rescued by brm^+t14.4

(Elfring et al., 1998)

Not rescued by

brm¹ is not rescued by brm^{Δ549-610.Tag:HA}

(Elfring et al., 1998)

Comments

Homozygous and hemizygous lethality is rescued by brm^+t14.4. Four copies of brm^{Δ549-610.T:Ivir\HA1} fail to rescue the lethality of brm¹ homozygotes.

(Elfring et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

brm¹

(Di Stefano et al., 2011, Rodriguez-Jato et al., 2011, Vázquez et al., 2008, Chang et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

Open Close