FB2024_03 , released June 25, 2024
Allele: Dmel\Abd-BMcp-1
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General Information
Symbol
Dmel\Abd-BMcp-1
Species
D. melanogaster
Name
FlyBase ID
FBal0000145
Feature type
allele
Associated gene
Dmel\Abd-B
Associated Insertion(s)
Carried in Construct
Also Known As
Mcp1, Mcp, Abd-BMcp
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Jeong et al., 2006, Karch et al., 1994)
Mutagen
spontaneous
(Karch et al., 1985)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Kuhn et al., 1993, Karch et al., 1985)
Description

The deletion uncovers the nuclease hypersensitive region of the Mcp, continuing distally towards the iab-5 region.

(Muller et al., 1999)

3.5kb deletion in the cis regulatory region, removing a silencer element MCP725.

(Busturia et al., 1997)

Deletion of a 3.6kb DNA segment from the region in between iab-4 and iab-5 cis-regulatory domains (from map position +94 to +97.6kb in the bithorax complex).

(Karch et al., 1994)

Alteration at coordinate +94-97.6kb, proximal to the Abd-B transcript.

(Kuhn et al., 1993)

94-97.6 kb deleted.

(Karch et al., 1985)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
X78982
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference

      Abd-BMcp-1 embryos exhibit in parasegment 9 a pattern of Abd-B expression that is normally seen in parasegment 10, both in the epidermis and in the ventral nerve cord.

      (Sanchez-Herrero, 1991)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      abdominal segment 4

      (Bejarano and Busturia, 2004, Karch et al., 1994)

      abdominal segment 5 | ectopic

      (Bejarano and Busturia, 2004)

      adult cuticle & abdominal segment 3 | male

      (Kopp et al., 2000)

      adult cuticle & abdominal segment 4 | male

      (Kopp et al., 2000)
      Detailed Description
      Statement
      Reference

      heterozygous mutant adults have a pigments abdominal segment 4, showing a transformation of the a4 to a5. This is seen in 100% of mutants, with constant and high expressivity.

      (Bejarano and Busturia, 2004)

      Heterozygous males show a decrease in the total amount of both monoene and 7,11-diene cuticular hydrocarbons compared to wild-type males. Heterozygous females show a significant increase in the level of monoene cuticular hydrocarbons and a significant decrease in the level of 7,11-diene cuticular hydrocarbons compared to wild-type females.

      (Wicker-Thomas and Jallon, 2001)

      In males homozygous for Abd-BMcp-1,Abd-BSab-1, male specific pigmentation is expanded into A3 and A4.

      (Kopp et al., 2000)

      A4 is transformed to A5 identity and is a darkly pigmented.

      (Karch et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Abd-BMcp-1/Abd-BMcp-1 is a suppressor | partially of visible | recessive phenotype of brkMcp

      (Kyrchanova and Georgiev, 2010)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Abd-BMcp-1 has phenotype, enhanceable by Pcl1

      (Duncan, 1982)
      Suppressed by
      Statement
      Reference

      Abd-BMcp-1 has abdominal segment 5 | ectopic phenotype, suppressible by TrlR85

      (Bejarano and Busturia, 2004)

      Abd-BMcp-1 has abdominal segment 4 phenotype, suppressible by TrlR85

      (Bejarano and Busturia, 2004)
      Suppressor of
      Statement
      Reference

      Abd-BMcp-1/Abd-BMcp-1 is a suppressor | partially of wing phenotype of brkMcp

      (Kyrchanova and Georgiev, 2010)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The penetrance of the wing defect phenotype caused by brkMcp is decreased to 7.7% if the animals are also homozygous for Abd-BMcp-1.

      (Kyrchanova and Georgiev, 2010)

      96% of Abd-BMcp-1, TrlR85 double heterozygotes have a partially de-pigmented abdominal segment 4.

      (Bejarano and Busturia, 2004)

      The third abdominal segment is transformed towards segment five or six in males also carrying ph-d1 or ph-d2.

      (Dura et al., 1985)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (5)
      Notes on Origin
      Discoverer

      Crosby.

      M. Crosby.

      (Karch et al., 1985)
      Comments
      Comments

      m- r+ mutant, with defect in spatial regulation of Abd-B function. No effect on penetrance of head defect phenotype when in trans with Abd-Biab9-tuh-3.

      (Kuhn et al., 1993)

      The phenotype of Abd-BMcp-1/Abd-BMcp-1 closely resembles that of Abd-BCst/+.

      (Crosby et al., 1993)

      DNase hypersensitivity assays reveal the deletion contains one very prominent nuclease sensitive region as well as several minor hypersensitive sites. Mcp appears to be associated with an unusual chromatin structure.

      (Karch et al., 1994)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (5)
      References (22)