FB2024_03 , released June 25, 2024
Allele: Dmel\brkMcp
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General Information
Symbol
Dmel\brkMcp
Species
D. melanogaster
Name
FlyBase ID
FBal0280187
Feature type
allele
Associated gene
Dmel\brk
Associated Insertion(s)
P{Ey(FRT.e)Mcp340Y(loxP.McpR)W}brkMcp
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{Ey(FRT.e)Mcp340Y(loxP.McpR)W}brkMcp
    Cytology
    Description

    Insertion of a P{Ey(FRT.e)Mcp340Y(loxP.McpR)W} element 30kb downstream of the brk gene.

    (Kyrchanova and Georgiev, 2010)
    Allele components
    Component
    Use(s)
    Also carries
    FRT
    loxP
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        30% of mutant animals (hemizygous males and homozygous females) have wing defects.

        (Kyrchanova and Georgiev, 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        NOT suppressed by
        Statement
        Reference

        brkMcp has visible | recessive phenotype, non-suppressible by Abd-BMcp-H27/Abd-BMcp-H27

        (Kyrchanova and Georgiev, 2010)
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        brkMcp has wing phenotype, suppressible | partially by Abd-BMcp-1/Abd-BMcp-1

        (Kyrchanova and Georgiev, 2010)

        brkMcp has wing phenotype, suppressible | partially by Abd-BFab7-1/Abd-BFab7-1

        (Kyrchanova and Georgiev, 2010)
        NOT suppressed by
        Statement
        Reference

        brkMcp has wing phenotype, non-suppressible by Abd-BMcp-H27/Abd-BMcp-H27

        (Kyrchanova and Georgiev, 2010)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The penetrance of the wing defect phenotype caused by brkMcp is decreased to 7.7% if the animals are also homozygous for Abd-BMcp-1.

        The penetrance of the wing defect phenotype caused by brkMcp is decreased to 14.5% if the animals are also homozygous for Abd-BFab7-1.

        The penetrance of the wing defect phenotype caused by brkMcp is unaffected if the animals are also homozygous for Abd-BMcp-H27.

        (Kyrchanova and Georgiev, 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        brkKG08470

        (Kyrchanova and Georgiev, 2010)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        brkMcp
        (Kyrchanova and Georgiev, 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)