FB2024_03 , released June 25, 2024
Allele: Dmel\ph-d1
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General Information
Symbol
Dmel\ph-d1
Species
D. melanogaster
Name
FlyBase ID
FBal0013722
Feature type
allele
Associated gene
Dmel\ph-d
Associated Insertion(s)
Carried in Construct
Also Known As
ph1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Dura et al., 1987, Dura et al., 1985)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Dura et al., 1987)
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults viable.

      (Dura et al., 1987)

      Homozygous female or hemizygous male flies often show a complete loss of the callus and bristles on the humerus. The prothoracic spiracle is unaffected. The second and third legs are often partially transformed towards the first leg. This transformation is restricted to the anterior compartment, and is particularly noticeable distally, where an extra sex comb appears. The first abdominal segment occasionally shows a partial transformation to a more posterior segment; dorsally, pigment and large bristles appear on the tergite, and ventrally, the sternite acquires bristles characteristic of the second or third abdominal segment. The fourth abdominal segment is often partially transformed to the fifth or sixth abdominal segment in males. Lethal over deficiencies that uncover the locus.

      (Dura et al., 1985)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Abd-BUab-1, ph-d1 has lethal phenotype

      (Dura et al., 1985)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      ph-d1 is an enhancer of phenotype of Pc3

      (Dura et al., 1985)
      Other
      Statement
      Reference

      Abd-BMcp-1, ph-d1 has abdominal segment 3 phenotype

      (Dura et al., 1985)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The abdominal transformations are enhanced by Df(3R)P9, and suppressed by Dp(3;3)P5. The leg transformations are suppressed by Dp(3;3)D1, and enhanced by Df(3R)Scr. Dominant enhancer of Pc3. Interacts with esc20. Lethal in combination with Abd-BUab-1. The third abdominal segment is transformed towards segment five or six in males also carrying Abd-BMcp-1. Does not interact with AntpHu.

      (Dura et al., 1985)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Gans and Komitopoulou.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ph-d1
      ph1
      (Dura et al., 1987, Dura et al., 1985)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)