Tel, Telomere elongation, dIno80
Please see the JBrowse view of Dmel\Ino80 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the chromatin remodeling Ino80 complex.
The DBINO region is involved in binding to DNA.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ino80 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
The highest Ino80 expression levels are observed at the onset of metamorphosis, from puparium formation to 2 days after puparium formation by qPCR analysis.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ino80 in JBrowse3-66
3-69.5
3-67.8
3-69
Maps to approximately 3-69.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
New stable cell line derived from S2-Invitrogen : Stable S2 cell lines were created to study chromatin remodeling. The base S2[OsTir1] was created and selected core proteins from the four main sub-families of ATP-dependent chromatin remodelers (Snr1, Iswi, Ino80, and Chd1) as well as SWI/SNF component Brd7-9 were inserted to create S2OsTir1-Snr1-AID, S2OsTir1-Iswi-AID, S2OsTir1-Ino80-AID, S2OsTir1-Chd1-AID, and S2OsTir1-Brd7-AID for component depletion studies.
DNA-protein interactions: genome-wide binding profile assayed for Ino80 protein in S2 cells; GEO accession number GSE32404.
Tel1 is a dominant genetic factor that increases addition of HeT-A and TART-elements to telomeres.
Source for merge of: Ino80 CG31212
Source for merge of: Ino80 Tel
Annotation CG18491 split into CG31212 and CG31244 in release 3 of the genome annotation. Release 3 annotation CG31212 contains sequences corresponding to release 2 annotations CG3602, CG14279 and parts of CG18491.
