FlyBase Gene Report: Dmel\Syx7

General Information

Symbol

Dmel\Syx7

Species

D. melanogaster

Name

Syntaxin 7

Annotation Symbol

CG5081

Feature Type

protein_coding_gene

FlyBase ID

FBgn0267849

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Syntaxin 7 (Syx7) encodes a SNARE protein that is part of the core machinery (including the products of Rab5, Rbsn-5, and Vps45) by which endocytic cargo vesicles fuse with the early endosome. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Avl, Avalanche, braided, Syntaxin, STX7

Key Links

Genomic Location

Cytogenetic map

78D2-78D2

Sequence location

3L:21,445,834..21,448,128 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:21445834..21448128

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (20 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:Vps33B; FB:FBgn0039335

(Akbar et al., 2009)

inferred from physical interaction with FLYBASE:Vps45; FB:FBgn0261049

(Morrison et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables SNAP receptor activity

non-traceable author statement

(Littleton et al., 1999)

inferred from biological aspect of ancestor with PANTHER:PTN000461349

(GO Reference Genome Project, 2011-)

enables SNARE binding

inferred from sequence or structural similarity with RGD:619747

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000461349

(GO Reference Genome Project, 2011-)

Biological Process (11 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in endosomal vesicle fusion

inferred from mutant phenotype

(Morrison et al., 2008)

involved_in establishment or maintenance of apical/basal cell polarity

inferred from mutant phenotype

(Lu and Bilder, 2005)

involved_in multicellular organism growth

inferred from mutant phenotype

(Colombani et al., 2012)

involved_in negative regulation of imaginal disc growth

inferred from mutant phenotype

(Gerlach et al., 2018)

involved_in plasma membrane to endosome transport

inferred from mutant phenotype

(Morrison et al., 2008)

involved_in positive regulation of endocytosis

inferred from mutant phenotype

(Lu and Bilder, 2005)

involved_in pupariation

inferred from mutant phenotype

(Colombani et al., 2012)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in intracellular protein transport

inferred from biological aspect of ancestor with PANTHER:PTN000461349

(GO Reference Genome Project, 2011-)

involved_in vesicle docking

inferred from biological aspect of ancestor with PANTHER:PTN000461349

(GO Reference Genome Project, 2011-)

involved_in vesicle fusion

inferred from biological aspect of ancestor with PANTHER:PTN000461349

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with RGD:619747

(Gene Ontology Curators, 2002-)

involved_in vesicle-mediated transport

inferred from electronic annotation with InterPro:IPR010989

(InterPro Project Members, 2004-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in early endosome

inferred from direct assay

(Morrison et al., 2008, Lu and Bilder, 2005)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

is_active_in endomembrane system

inferred from biological aspect of ancestor with PANTHER:PTN000461349

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR006011, InterPro:IPR010989

(InterPro Project Members, 2004-)

located_in plasma membrane

non-traceable author statement

(Littleton et al., 1999)

part_of SNARE complex

inferred from sequence or structural similarity with RGD:619747

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000461349

(GO Reference Genome Project, 2011-)

is_active_in synaptic vesicle

inferred from biological aspect of ancestor with PANTHER:PTN000751604

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Qa-SNAREs

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

Qa-SNAREs -: Q-SNAREs are members of the SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptor) family that mediate vesicle-fusion. SNAREs are cytoplasmic, membrane-anchored proteins that contain a 60 amino acid SNARE domain. Three Q-SNAREs domains from the target membrane and one R-SNARE domain from the vesicle interact to form a four four-helix bundle that pulls the two membranes in close proximity and promotes fusion. After fusion, the complexes are dissembled by NSF (N-ethylmaleimide-sensitive factor) and SNAPs (Soluble NSF Attachment Proteins). Q-SNAREs are named from their contribution of a conserved glutamine (Q) residue to the helix bundle. Q-SNARE domains are designated a, b or c, depending on their position within the helix bundle. (Adapted from PMID:15893389 and FBrf0216182).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Syx7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7K0X9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

gene

(Ghabrial et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Syx7-RA

FBtr0078351

NM_168905

1573

282

Syx7-RB

FBtr0078352

NM_168906

1610

282

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Syx7-PA

FBpp0078007

31.8

282

6.81

FBpp0078008

31.8

282

6.81

Q7K0X9

NP_730633

AAF51726

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

282 aa isoforms: Syx7-PA, Syx7-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7K0X9

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Syx7 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Syx7_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.35

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval hemocyte

• early phagosome

(Rahman et al., 2012)

third instar larval stage

cell

• early endosome

(Yuva-Aydemir et al., 2011)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

organism

(Rahman et al., 2012)

Additional Descriptive Data

Syx7 protein is localized to early phagosomes in hemocytes.

(Rahman et al., 2012)

Marker for

early endosome

(Yuva-Aydemir et al., 2011, Vaccari et al., 2010)

Subcellular Localization

CV Term

Evidence

References

located_in early endosome

inferred from direct assay

(Morrison et al., 2008, Lu and Bilder, 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Syx7 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Syx7

View exonic expression by tissue for Dmel\Syx7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36173/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267849

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086377

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267849

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5081

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Syx7

Transgenic constructs containing regulatory region of Syx7

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)BSC836

(Schottenfeld-Roames et al., 2014)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Mef2.PR

Syx7^GD2767

lethal | somatic clone

Syx7¹

lethal - all die before end of first instar larval stage | recessive

Syx7¹

lethal - all die before end of pupal stage, with Scer\GAL4^en-e16E

Syx7^RNAi.UAS.cLa

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Syx7^GD2767

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Syx7^GD2767

viable, with Scer\GAL4^tin.CΔ4

Syx7^GD2767

Sterility

Allele

female sterile germline-dependent

Syx7¹

Other Phenotypes

Allele

abnormal cell polarity, with Scer\GAL4^en-e16E

Syx7^RNAi.UAS.cLa

abnormal cell polarity | somatic clone

Syx7¹

abnormal cell shape | somatic clone

Syx7¹

abnormal developmental rate, with Scer\GAL4^rn.PU

Syx7^KK101990

abnormal developmental rate | somatic clone

Syx7¹

abnormal neuroanatomy | P-stage | somatic clone

Syx7¹

hyperplasia, with Scer\GAL4^en-e16E

Syx7^RNAi.UAS.cLa

hyperplasia | somatic clone

Syx7¹

increased body size, with Scer\GAL4^rn-GAL4-5

Syx7^GD2767

increased body size | larval stage | somatic clone

Syx7¹

neoplasia, with Scer\GAL4^rn-GAL4-5

Syx7^GD2767

neoplasia | somatic clone

Syx7¹

some die during first instar larval stage | recessive

Syx7¹

some die during pupal stage, with Scer\GAL4^en-e16E

Syx7^RNAi.UAS.cLa

some die during pupal stage, with Scer\GAL4^pnr-MD237

Syx7^GD2767

Phenotype manifest in

Allele

dendritic tree | P-stage | somatic clone

Syx7¹

early endosome | somatic clone

Syx7^brd1615

embryonic/larval tracheal system

Syx7^brd1615

epithelium, with Scer\GAL4^NP1624

Syx7^KK101990

eye | somatic clone

Syx7^brd1615

eye-antennal disc & cell & adherens junction | ectopic | somatic clone

Syx7¹

eye-antennal disc | somatic clone

Syx7¹

eye disc | somatic clone

Syx7¹

female germline cyst, with Scer\GAL4^NP1624

Syx7^KK101990

follicle cell | somatic clone

imaginal disc, with Scer\GAL4^rn-GAL4-5

Syx7^GD2767

larval dorsal multidendritic neuron ddaC | P-stage | somatic clone

Syx7¹

terminal tracheal cell

Syx7^brd1615

terminal tracheal cell | somatic clone

wing disc, with Scer\GAL4^rn-GAL4-5

Syx7^GD2767

wing disc posterior compartment, with Scer\GAL4^en-e16E

Syx7^RNAi.UAS.cLa

yolk granule | germline clone

Syx7¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (12)

Hsap\STX7

14 of 14

Yes

Hsap\STX12

13 of 14

Yes

4 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Stx7

14 of 14

Yes

Rnor\Stx12

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (11)

Mmus\Stx7

14 of 14

Yes

Mmus\Stx12

12 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (8)

Xtro\stx7

11 of 13

Yes

Xtro\stx12

10 of 13

Yes

Xtro\tsnare1

3 of 13

Xtro\mpzl3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (18)

Drer\stx7l

13 of 14

Yes

Drer\stx12

12 of 14

Yes

Drer\stx12l

12 of 14

Yes

5 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\syx-7

12 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP005543

12 of 12

Yes

5 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (19)

Atha\VAM3

13 of 13

Yes

Atha\SYP23

12 of 13

Yes

Atha\SYP21

11 of 13

Yes

Atha\ATSYP24

8 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\PEP12

8 of 13

Yes

Scer\VAM3

5 of 13

Yes

Scer\TLG2

2 of 13

Scer\SED5

1 of 13

Scer\SSO2

1 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\pep12

8 of 12

Yes

Spom\tlg2

2 of 12

Spom\psy1

1 of 12

Spom\sed5

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Syx7. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

8 of 13

4 of 13

3 of 13

3 of 13

3 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, epithelial, STX7,12-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

Syx7¹

model of carcinoma

CEA

(Lu and Bilder, 2005)

Syx7^GD2767

model of cancer

CEA

(Santabárbara-Ruiz and Léopold, 2021)

Syx7³¹¹⁹

model of cancer

CEA with Ras85D^V12.cUa.UAS

(Liu et al., 2022)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

Syx7¹

model of carcinoma

is ameliorated by Syx7^hs.PL

(Lu and Bilder, 2005)

Syx7^hs.PL

ameliorates carcinoma

modeled by Syx7¹

(Lu and Bilder, 2005)

Syx7^GD2767

model of cancer

is exacerbated by Oatp33Eb^UAS.cSa

(Santabárbara-Ruiz and Léopold, 2021)

is exacerbated by Oatp74D^UAS.cOa

(Santabárbara-Ruiz and Léopold, 2021)

Syx7^G6457

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

Syx7^JF02436

exacerbates Parkinson's disease

modeled by Hsc70-5^KK100233

(Zhu et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

14 of 14

13 of 14

TSNARE1; t-SNARE domain containing 1

4 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Syx7 - AttD

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Bet1

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - CG14767

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - CG15098

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - CG3164

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - CG7668

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Frl

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Gos28

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Hsap\APOL1

anti tag coimmunoprecipitation, anti tag western blot

(Lee et al., 2023)

Syx7 - Membrin

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Past1

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Pvr

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Sec20

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Sec22

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Slh

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Snap24

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Snap25

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Snap29

experimental knowledge based, anti bait coimmunoprecipitation, peptide massfingerprinting

(Morelli et al., 2014, Guruharsha et al., 2011)

Syx7 - Syb

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Syx13

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Syx16

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Syx18

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Syx1A

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Syx4

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Syx5

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Syx8

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Use1

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Vamp7

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - Vha100-1

pull down, western blot, anti bait coimmunoprecipitation

(Williamson et al., 2010)

Syx7 - Vps33B

anti bait coimmunoprecipitation, anti tag western blot

(Akbar et al., 2009)

Syx7 - Vps45

pull down, anti tag western blot

(Morrison et al., 2008)

Syx7 - Ykt6

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - fax

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - koko

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - αSnap

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - γSnap1

experimental knowledge based

(Guruharsha et al., 2011)

Syx7 - γSnap2

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Syx7

suppressible

aPKC

(Lu and Bilder, 2005)

Syx7

suppressible

ben

(Andersen et al., 2015)

Syx7

suppressible

bsk

(Andersen et al., 2015)

Syx7

suppressible

grnd

(Andersen et al., 2015)

Syx7

suppressible

hep

(Andersen et al., 2015)

Syx7

suppressible

Ilp8

(Romão et al., 2021, Colombani et al., 2012)

Syx7

suppressible

Moe

(Schottenfeld-Roames et al., 2014)

Syx7

suppressible

puc

(Colombani et al., 2012)

Syx7

suppressible

(Boone et al., 2016)

Syx7

suppressible

Tab2

(Andersen et al., 2015)

Syx7

suppressible

Tak1

(Andersen et al., 2015)

Syx7

suppressible

yki

(Boone et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Hsc70-5

enhanceable

Syx7

(Zhu et al., 2021)

External Data

Linkouts

MIST (protein-protein) - An integrated Molecular Interaction Database

36173

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

78D2-78D2

Sequence location

3L:21,445,834..21,448,128 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

78D2-78D2

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Meiotic recombination and chromosomal deficiencies were used to map Syx7¹.

(Lu and Bilder, 2005)

78D-78E

(Lu and Bilder, 2005)

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-43.8

(Comeron et al., 2012)

(Ghabrial et al., 2011)

Left of (cM)

Right of (cM)

Notes

Maps to 3L.

(Ghabrial et al., 2011)

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

29546

y¹ v¹; P{TRiP.JF02436}attP2

84033

y¹ v¹; P{TKO.GS04402}attP40

52000

w^*; P{neoFRT}80B Syx7¹/TM6B, Tb¹

51644

w^*; P{neoFRT}80B Syx7⁴/T(2;3)TSTL, CyO: TM6B, Tb¹

27154

y¹ w^*; P{EP}Syx7^G4416/TM3, Sb¹ Ser¹

28476

y¹ w^*; P{EP}Syx7^G6457/TM3, Sb¹ Ser¹

63103

w^*; P{GAL4-btl.S}2, P{UASp-Act5C.T:GFP}2; Syx7^brdQ6 P{FRT(w^hs)}2A P{neoFRT}82B/TM3, P{tubP-GAL80}3, Sb¹

VDRC

v107264

P{KK101990}VIE-260B

v5413

w¹¹¹⁸; P{GD2767}v5413

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (97)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD23667

Other clones

DPiM_LD23667

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0267849

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

avl is involved in endocytic trafficking.

(Bilder and Lu, 2005)

avl mutant tissues form tumour-like growths. Loss of function avl mutants cause columnar monolayered epithelia to become rounded and mulitlayered and to have apical proteins and adherens junctions ectopically localized throughout the basolateral surface.

(Bilder and Lu, 2005)

Ovarian follicular cells are rounded and form a multilayered structure in mutant females (in contrast to the monolayer of columnar-shaped follicle cells found in the wild type). Eye discs consisting mostly of avl mutant cells show massive overproliferation, resulting in tumour-like growths. Mutant cells ectopically localize apical proteins as well as adherens junctions throughout the basolateral cell surface.

(Lu and Bilder, 2005)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: Syx7 avl

(Lu and Bilder, 2005)

Source for merge of: Syx7 braided

(Schottenfeld-Roames et al., 2014)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Syx7 CG5081

(McLennan, 2001.5.22)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

Aval

(Xu et al., 2011)

CG5081

(Laffafian and Tepass, 2019, Harris et al., 2016, Hosono et al., 2015, Yano et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Lu and Bilder, 2005)

Dm Syx7

(Littleton, 2000)

DmSyx7

(McLennan, 2001.5.22)

FCP-C

(Horne-Badovinac et al., 2012)

STX7

(Gordon et al., 2017, Roman-Fernandez and Bryant, 2016)

SYX7

(Lloyd et al., 2000)

Syx

(Wagh et al., 2006)

braided

dSyn7

(Pulipparacharuvil et al., 2005)

syx7

(Jay et al., 2021, González-Méndez et al., 2020, Sandmann et al., 2007)

syx7/avl

(Gilbert et al., 2009)

Name Synonyms

Avalanche

(Liu et al., 2022, Amoyel and Bach, 2014, Wang et al., 2014, Gailite et al., 2012, Li et al., 2012, Akbar et al., 2011, Yuva-Aydemir et al., 2011, Demontis and Dahmann, 2009, Nagaraj and Banerjee, 2009, Harris and Tepass, 2008, Vaccari et al., 2008, Akbar et al., 2007, Jaekel and Klein, 2006)

Syntaxin

(Hossain et al., 2008, Kittel et al., 2006, Pereanu and Hartenstein, 2006, Wagh et al., 2006)

Syntaxin 7

(Saadin and Starz-Gaiano, 2018, Harris et al., 2016, Yano et al., 2012, McLennan, 2001.5.22)

Syntaxin7

(Schottenfeld-Roames et al., 2014, Suprabha et al., 2003)

avalanche

(Romão et al., 2021, Cong et al., 2018, Vaufrey et al., 2018, Andersen et al., 2015, Schottenfeld-Roames et al., 2014, Vaccari et al., 2009, Tountas and Fortini, 2007, Solecki et al., 2006, Lu and Bilder, 2005, Lu and Bilder, 2005)

braided

(Schottenfeld-Roames et al., 2014, Ghabrial et al., 2011)

dSyntaxin-7

(Pulipparacharuvil et al., 2005)

synatxin7/avalanche

(Gilbert et al., 2009)

syntaxin

(Dumstrei et al., 2003)

syntaxin 7

(Mukherjee et al., 2020)

syntaxin-7

(Cong et al., 2018)

Secondary FlyBase IDs

FBgn0264632
FBgn0086377
FBgn0033583
FBgn0082601

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36173

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7K0X9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7K0X9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7K0X9

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36173/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267849

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267849

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5081

MARRVEL_MODEL - MARRVEL (model organism gene)

36173

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0267849

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Syx7_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086377

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0267849

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5081

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032389

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

36173

References (133)

The following external sites may use different assemblies or annotations than FlyBase.

0.35

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