Rad21, cohesin, Scc1, DRAD21, l(3)80Fh
constituent of the cohesin complex, functions in chromosome cohesion, spindle morphology, dynamics of a chromosome passenger protein, and stability of the cohesin complex
Please see the JBrowse view of Dmel\vtd for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.53
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Gene model reviewed during 5.55
2.3 (northern blot)
None of the polypeptides share 100% sequence identity.
715 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\vtd using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\vtd in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
vtd is required for synaptonemal complex maintenance, but not sister chromatid cohesion, during female meiosis.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show longer metaphase spindles.
Genetic analysis suggests that wild type Rad21 function is required for proper progression through mitosis, in particular for normal chromosome segregation.
Mutant cells delay in prometaphase with normally condensed, but prematurely separated sister chromatids and with abnormal spindle morphology.
Transiently named CG40222 in release 3 of the genome annotation.
One of a series of EMS-induced lethals detected by failure to complement proximal heterochromatic deficiencies in 3L or 3R, which resulted from detachments, i.e., reconstitutions of normal third chromosomes, from irradiated C(3L)RM/C(3R)RM-bearing females; a large set of such proximal heterochromatic deficiencies was employed in deficiency mapping of these lethals (Marchant and Holm, 1988).
Source for merge of: vtd l(3)80Fh
Source for merge of: vtd Rad21
Source for merge of: Rad21 scc1
"vtd" does not correspond to "Dbp80".
Source for merge of Rad21 scc1 was sequence comparison ( date:000202 ).