Mtn, metallothionein
Please see the JBrowse view of Dmel\MtnA for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MtnA using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\MtnA in JBrowse3-49
3-46.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New stable cell line derived from S2-unspecified : An S2 cell line stably expressing pMT-N (full-length N under the control of the MtnA promoter) was created.
New stable cell line derived from S2-unspecified : S2 cell lines expressing mutant mle proteins tagged with Tag:FLAG under the control of the MtnA promoter were generated.
New stable cell line derived from S2-unspecified : S2 cells stably expressing GFP-tagged Rel under the control of the MtnA promoter were obtained from the laboratory of E. Foley.
New stable cell line derived from S2-unspecified : Stable S2 cell lines expressing Mob4-GFP under the control of the MtnA promoter were generated.
New stable cell line derived from S2-unspecified : Stable S2 cells expressing rpr under the control of the MtnA promoter (S2-Mt-reaper) were used.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
MtnA promoter expression induced by CuSO4 in recombinant baculovirus is inducible but 'leaky'.
Codes for metallothionein, a metal binding protein. Inducible by ingestion of Cu or Cd (but not Zn) ions. In larvae, it is expressed mainly in the midgut. No point mutations are available, but Dp(3;3)Mtn+H22 shows increased tolerance to Cd.
Source for merge of: MtnA BcDNA:GH18460
Source for merge of: MtnA anon-WO0153538.42 anon-WO0153538.44 anon-WO0153538.49
Source for merge of MtnA BcDNA:GH18460 was a shared cDNA ( date:030728 ).
Source for merge of MtnA anon-WO0153538.42 anon-WO0153538.44 anon-WO0153538.49 was sequence comparison ( date:051113 ).
