FB2024_03 , released April 23, 2024
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Citation
Yu, X., Tian, X., Wang, Y., Zhu, C. (2021). Metal-metal interaction and metal toxicity: a comparison between mammalian and D. melanogaster.  Xenobiotica 51(7): 842--851.
FlyBase ID
FBrf0249217
Publication Type
Research paper
Abstract
1. Non-essential heavy metals such as mercury (Hg), arsenic (As), cadmium (Cd), and aluminium (Al) are useless to organisms and have shown extensive toxic effects. Previous studies show that two main molecular mechanisms of metal toxicity are oxidative stress and metal-metal interaction which can disrupt metal homeostasis.2. In this paper, we mainly illustrate metal toxicity and metal-metal interaction through examples in mammalians and D. melanogaster (fruit fly).3. We describe the interference of metal homeostasis by metal-metal interactions in three aspects including replacement, cellular transporter competition, and disruption of the regulation mechanism, and elaborate the mechanisms of metal toxicity to better deal with the challenges of heavy metal pollution and related health problems.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Xenobiotica
    Title
    Xenobiotica; the fate of foreign compounds in biological systems.
    ISBN/ISSN
    0049-8254 1366-5928
    Data From Reference