FlyBase Allele Report: Dmel\MtnA[ΔATG]

General Information

Symbol

Dmel\MtnA^ΔATG

Species

D. melanogaster

Name

FlyBase ID

FBal0197945

Feature type

allele

Associated gene

Dmel\MtnA

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

FLPase

(Egli et al., 2006)

recombination

(Egli et al., 2006)

I-SceI

(Egli et al., 2006)

I-CreI

(Egli et al., 2006)

gene targeting by homologous recombination

(Egli et al., 2006)

Progenitor genotype

Cytology

Description

The MtnA ATG start codon and several neighbouring amino acids have been replaced by a NotI site.

(Egli et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Friedreich ataxia 1

modeled by fh^RNAi.UAS.cAa

(Soriano et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive

(Egli et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

MtnA^ΔATG mutants show reduced survival on 1mM copper concentrations in food compared to controls.

(Egli et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

MtnD^OreR, MtnD^OreR, MtnC^ΔATG, MtnC^ΔATG, MtnB^ΔATG, MtnB^ΔATG, MtnA^ΔATG, MtnA^ΔATG is an enhancer of visible phenotype of MTF-1^{Δ580-791.tub}

(Günther et al., 2012)

MtnD^OreR, MtnD^OreR, MtnC^ΔATG, MtnC^ΔATG, MtnB^ΔATG, MtnB^ΔATG, MtnA^ΔATG, MtnA^ΔATG is an enhancer of partially lethal - majority die phenotype of MTF-1^{Δ580-791.tub}

(Günther et al., 2012)

MtnD^OreR, MtnD^OreR, MtnC^ΔATG, MtnC^ΔATG, MtnB^ΔATG, MtnB^ΔATG, MtnA^ΔATG, MtnA^ΔATG is an enhancer of visible phenotype of MTF-1^{Δ637-791.tub}

(Günther et al., 2012)

MtnD^OreR, MtnD^OreR, MtnC^ΔATG, MtnC^ΔATG, MtnB^ΔATG, MtnB^ΔATG, MtnA^ΔATG, MtnA^ΔATG is an enhancer of partially lethal - majority die phenotype of MTF-1^{Δ637-791.tub}

(Günther et al., 2012)

Other

Statement

Reference

MtnA^ΔATG, MtnB^ΔATG, MtnC^ΔATG, MtnD^ΔATG has chemical sensitive phenotype

(Egli et al., 2006)

MtnA^ΔATG, MtnB^ΔATG, MtnC^ΔATG, MtnD^OreR has chemical sensitive phenotype

(Egli et al., 2006, Egli et al., 2006)

MtnA^ΔATG, MtnB^ΔATG, MtnD^OreR has chemical sensitive phenotype

(Egli et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

MtnD^OreR, MtnD^OreR, MtnC^ΔATG, MtnC^ΔATG, MtnB^ΔATG, MtnB^ΔATG, MtnA^ΔATG, MtnA^ΔATG is an enhancer of wing phenotype of MTF-1^{Δ580-791.tub}

(Günther et al., 2012)

MtnD^OreR, MtnD^OreR, MtnC^ΔATG, MtnC^ΔATG, MtnB^ΔATG, MtnB^ΔATG, MtnA^ΔATG, MtnA^ΔATG is an enhancer of wing phenotype of MTF-1^{Δ637-791.tub}

(Günther et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The wing defects seen in flies expressing MTF-1^{Δ580-791.tub} or MTF-1^{Δ761-791.tub} are enhanced by the "qMtn" mutant combination (MtnA^ΔATG MtnB^ΔATG MtnC^ΔATG MtnD^OreR) and the mutant flies show a very low eclosion rate.

(Günther et al., 2012)

MtnA^ΔATG MtnB^ΔATG MtnC^ΔATG MtnD^OreR quadruple mutants show little or no survival on 1mM copper or 100mM cadmium concentrations in food compared to controls.

MtnA^ΔATG MtnB^ΔATG MtnC^ΔATG MtnD^ΔATG quadruple mutants show little or no survival on 1mM copper or 100mM cadmium concentrations in food compared to controls.

(Egli et al., 2006)

MtnA^ΔATG MtnB^ΔATG MtnC^ΔATG MtnD^OreR quadruple mutants are viable and fertile, but are highly sensitive to copper and cadmium load in food, showing no survival on 0.5mM copper or 50μM cadmium concentrations. The quadruple mutants are not sensitive to copper depletion.

MtnA^ΔATG MtnB^ΔATG MtnD^OreR triple mutants show greatly reduced survival on 0.5mM copper or 50μM cadmium concentrations compared to controls.

With normal food, the life span of MtnA^ΔATG MtnB^ΔATG MtnC^ΔATG MtnD^OreR quadruple homozygotes is similar to that of controls. However, at 50μM copper, the mean life span of quadruple homozygous males is 6 days shorter than that of controls, and at 75μM copper, the mean life span of quadruple homozygous males is 14 days shorter than that of controls. The mean life span of quadruple homozygous females is 3 days shorter than that of controls at both 50μM and 75μM copper.

(Egli et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

MtnA^-

(Egli et al., 2006)

MtnA^ΔATG

(Soriano et al., 2016, Egli et al., 2006, Egli et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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