rad(2)201
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rad201 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\rad201 in JBrowse2-59.9 +/- 1.1
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The "rad201[1]" chromosome contains a number of lesions in two different genes. These are: F50L in the CG42382 annotation, and K61E, V93A and Y108H in the CG2412 annotation (corresponding to the Rad51C gene). In addition, an opus element is inserted in the Rad51C promoter region approximately 400bp upstream of the start codon. This mutant allele was isolated from a natural population, and thus it is not known which of the lesions are neutral and which cause the mutant phenotype.
The "rad201" complementation group has been associated with the "CG8016" annotation on FlyBase. However, evidence suggests that "rad201" instead corresponds to the neighbouring annotation, CG2412; the "rad2011" allele has a lesion within the CG2412 open reading frame (although no lesion has been found in the "rad201ZII-0670" allele), and the protein encoded by CG2412 interacts with Spf45 protein.
FlyBase curator comment: information corresponding to the "rad201" complementation group has been separated out from information corresponding to the "CG8016" annotation in FlyBase, since evidence suggests that the "rad201" complementation group instead may correspond to the neighbouring annotation, CG2412. In addition, the CG8016 annotation has been renamed CG42382 in release 5.10 of the genome annotation to avoid confusion. The "rad201" complementation group has not yet been associated with the CG2412 annotation in FlyBase, as a lesion in CG2412 was only found in one out of two rad201 alleles tested in this paper.
