FlyBase Gene Report: Dmel\Egm

General Information

Symbol

Dmel\Egm

Species

D. melanogaster

Name

Enigma

Annotation Symbol

CG9006

Feature Type

protein_coding_gene

FlyBase ID

FBgn0086712

Gene Model Status

Current

Stock Availability

6 publicly available

Enzyme Name (EC)

medium-chain acyl-CoA dehydrogenase (1.3.8.7)

Gene Summary

Enigma (Egm) encodes a mitochondrial oxidoreductase involved in oxidative stress response and lipid homeostasis. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(2)k14708

Key Links

Genomic Location

Cytogenetic map

48A3-48A3

Sequence location

2R:11,616,869..11,619,023 [-]

Recombination map

2-64

RefSeq locus

NT_033778 REGION:11616869..11619023

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables flavin adenine dinucleotide binding

inferred from electronic annotation with InterPro:IPR013786, InterPro:IPR037069

(InterPro Project Members, 2004-)

enables medium-chain fatty acyl-CoA dehydrogenase activity

inferred from biological aspect of ancestor with PANTHER:PTN000098033

(GO Reference Genome Project, 2011-)

enables oxidoreductase activity, acting on the CH-CH group of donors

inferred from electronic annotation with InterPro:IPR006091, InterPro:IPR009075, InterPro:IPR009100, InterPro:IPR013786, InterPro:IPR036250, InterPro:IPR037069, InterPro:IPR046373

(InterPro Project Members, 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in compound eye morphogenesis

inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647

(Verheyen et al., 1996)

involved_in fatty acid beta-oxidation

inferred from mutant phenotype

(Mourikis et al., 2006)

involved_in lipid homeostasis

inferred from mutant phenotype

(Mourikis et al., 2006)

involved_in negative regulation of cellular response to oxidative stress

inferred from mutant phenotype

(Mourikis et al., 2006)

involved_in response to endoplasmic reticulum stress

inferred from high throughput mutant phenotype

(Chow et al., 2013)

involved_in sexual reproduction

inferred from high throughput expression pattern

(Findlay et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in medium-chain fatty acid catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000098033

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in extracellular space

inferred from high throughput direct assay

(Findlay et al., 2008)

is_active_in mitochondrion

inferred from direct assay

(Murari et al., 2021)

located_in mitochondrion

inferred from direct assay

(Mourikis et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN002535634

(GO Reference Genome Project, 2011-)

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000098033

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ACYL-COA DEHYDROGENASES

MITOCHONDRIAL COMPLEX I INTERMEDIATE ASSEMBLY COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

medium-chain fatty acyl-CoA dehydrogenase activity

a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron- transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] (1.3.8.7)

RHEA 14477:

Summaries

Gene Snapshot

Enigma (Egm) encodes a mitochondrial oxidoreductase involved in oxidative stress response and lipid homeostasis. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

ACYL-COA DEHYDROGENASES -: Acyl-CoA dehydrogenases are oxidoreductases that oxidize acyl-CoA with the reduction of electron-transfer flavoprotein. They catalyze the first reaction of mitochondrial fatty acid beta-oxidation. (Adapted from PMID:19639238).
MITOCHONDRIAL COMPLEX I INTERMEDIATE ASSEMBLY COMPLEX -: The mitochondrial complex I intermediate assembly (MCIA) complex is an inner membrane complex involved in the assembly of Mitochondrial Complex I (MCI). (Adapted from PMID:32320651).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Egm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q5U117)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Egm-RA

FBtr0088090

NM_136843

2033

639

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Egm-PA

FBpp0087192

70.8

639

6.40

Q5U117

NP_610687

AAF58637

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q5U117

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Egm using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Egm_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.74

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic hindgut

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval posterior spiracle

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from high throughput direct assay

(Findlay et al., 2008)

is_active_in mitochondrion

inferred from direct assay

(Murari et al., 2021)

located_in mitochondrion

inferred from direct assay

(Mourikis et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Egm in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Egm

View exonic expression by tissue for Dmel\Egm

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0086712

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36242/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086712

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086712

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9006

Flygut - An atlas of the Drosophila adult midgut

FBgn0086712

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Egm

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Egm

Transgenic constructs containing regulatory region of Egm

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2R)en-B

(BDGP Project Members, 1994-1999)

Df(2R)en-SFX31

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gene not disrupted in

Df(2R)E3363

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)ix⁸⁷ⁱ³

(BDGP Project Members, 1994-1999)

In(2R)vg^W

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Egm^k14708

lethal - all die before end of larval stage

viable

Egm^H

Other Phenotypes

Allele

abnormal developmental rate | larval stage

abnormal developmental rate | pupal stage

Egm^H

long lived | dominant

Egm¹

short lived

Egm^H

some die during larval stage

some die during third instar larval stage

Egm¹

Phenotype manifest in

Allele

embryonic/larval fat body

Egm¹

eye disc

Egm¹

imaginal disc

Egm^k14708

wing disc

Egm¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\ACAD8

3 of 14

Yes

Hsap\ACAD9

3 of 14

Yes

Hsap\ACADL

3 of 14

Yes

Hsap\ACADVL

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Acadl

3 of 14

Yes

Rnor\Acadvl

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Rnor\Acad11

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (14)

Mmus\Acadl

3 of 14

Yes

Mmus\Acadvl

3 of 14

Yes

Mmus\Acad8

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (11)

Xtro\acad9

2 of 13

Yes

Xtro\acad8

1 of 13

Yes

Xtro\acad10

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (13)

Drer\acad8

3 of 14

Yes

Drer\acad9

3 of 14

Yes

Drer\acadl

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (22)

Cele\acdh-9

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\acdh-13

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (12)

Agam\AgaP_AGAP000454

11 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\ACX2

2 of 13

Yes

Atha\ACX4

2 of 13

Yes

Atha\IVD

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\POX1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (4)

Ecol\aidB

1 of 11

Yes

Ecol\caiA

1 of 11

Yes

Ecol\fadE

1 of 11

Yes

Ecol\ydiO

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Egm. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (13)

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Ivd

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Egm^HMS01630

model of nuclear type mitochondrial complex I deficiency 20

CEA

(Murari et al., 2021)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

ACADVL; acyl-CoA dehydrogenase very long chain

model of very long chain acyl-CoA dehydrogenase deficiency

IEA

(FlyBase, 2019-)

ACAD9; acyl-CoA dehydrogenase family member 9

model of nuclear type mitochondrial complex I deficiency 20

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ACAD8; acyl-CoA dehydrogenase family member 8

3 of 14

604773

ISOBUTYRYL-CoA DEHYDROGENASE DEFICIENCY; IBDD

ACAD9; acyl-CoA dehydrogenase family member 9

3 of 14

611103

MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 20; MC1DN20

nuclear type mitochondrial complex I deficiency 20

ACADL; acyl-CoA dehydrogenase long chain

3 of 14

609576

ACADVL; acyl-CoA dehydrogenase very long chain

3 of 14

609575

ACYL-CoA DEHYDROGENASE, VERY LONG-CHAIN, DEFICIENCY OF; ACADVLD

very long chain acyl-CoA dehydrogenase deficiency

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Egm - Rab6

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

Egm

(Verheyen et al., 1996)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62030

DroID - A comprehensive database of gene and protein interactions.

FBgn0086712

MIST (protein-protein) - An integrated Molecular Interaction Database

36242

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

2-methyl-branched fatty acid β-oxidation

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-64

Cytogenetic map

48A3-48A3

Sequence location

2R:11,616,869..11,619,023 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

48A3-48A3

Limits computationally determined from genome sequence between P{lacW}l(2)k13403^k13403&P{lacW}Egm^k14708 and P{lacW}oho48A^k06524

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Mapped using complementation analysis (details unspecified).

(Mourikis and Artavanis-Tsakonas, 2001)

48A4-48A5

(Mourikis and Artavanis-Tsakonas, 2001)

48A3-48A5

(determined by in situ hybridisation)

(Spradling et al., 1999)

48A3-48A5

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-64

(FlyBase, 2016)

2-65.7

(Comeron et al., 2012)

(Verheyen et al., 1996)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

603522

y¹ w¹; P{TKO-UAS.GS06262}attP40/CyO

11133

y¹ w^67c23; P{lacW}Egm^k14708/CyO

36739

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01630}attP40

Kyoto

111342

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}Egm^k14708 /CyO y⁺

NIG-Fly

HMS01630

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01630}attP40

2RG-1573

y² VhaAC39-1^cho-1 v¹; P{U6-Egm.NIG.sgRNA}attP40/CyO

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (104)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LP02372

Other clones

DPiM_LP02372

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0086712

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0086712

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Reduced levels of Egm decelerate the rate of development in a dosage-dependent manner. Cells lacking Egm produce smaller wing margin bristles than in wild-type.

(Mourikis et al., 2006)

Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.

(Roch et al., 1998)

Complementation group isolated in a screen for dominant enhancers and suppressors of N^act.sev or N^nucl.sev.

(Verheyen et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: l(2)k14708 CG9006

(FlyBase, 1996-)

Source for merge of: Egm l(2)k14708

(Mourikis, 2006.3.2)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Acyl CoA DH

(Wheeler et al., 2004)

CG9006

(National Institute of Genetics Fly Stocks, 2022-, Murari et al., 2021, Chen et al., 2015, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Spresser et al., 2008, Comet et al., 2006, Wheeler et al., 2004, Giot et al., 2003, Dworkin et al., 2001)

Egm

(Parkhitko et al., 2020, Li et al., 2019, Transgenic RNAi Project members, 2017-, Dent et al., 2015, Luck et al., 2014, Chow et al., 2013, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Pezzulo et al., 2012, Kühnlein, 2010, Kwon et al., 2009, Mourikis et al., 2006, Mourikis et al., 2006)

dACAD9

(Murari et al., 2021)

egm

(Verheyen et al., 1996)

l(2)k14708

(Zhang et al., 2007, Spradling et al., 1999, Roch et al., 1998)

Name Synonyms

Enigma

(Kühnlein, 2010, Mourikis, 2006.3.2, Mourikis et al., 2006, Mourikis et al., 2006, Mourikis, 2003)

enigma

(Verheyen et al., 1996)

l(2)k14708

(Cammarato et al., 2011)

lethal (2) k14708

Secondary FlyBase IDs

FBgn0033637
FBgn0021848
FBgn0019818

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36242

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q5U117

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q5U117

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q5U117

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0086712

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36242/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086712

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086712

FlyMine - An integrated database for Drosophila genomics

FBgn0086712

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9006

MARRVEL_MODEL - MARRVEL (model organism gene)

36242

Linkouts

BioGRID - A database of protein and genetic interactions.

62030

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0086712

DroID - A comprehensive database of gene and protein interactions.

FBgn0086712

DRSC - Results frm RNAi screens

FBgn0086712

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Egm_1

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0086712

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

2-methyl-branched fatty acid β-oxidation

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9006

Flygut - An atlas of the Drosophila adult midgut

FBgn0086712

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0086712

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001370

MIST (protein-protein) - An integrated Molecular Interaction Database

36242

References (56)

The following external sites may use different assemblies or annotations than FlyBase.

1.74

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