FB2024_03 , released June 25, 2024
Gene: Dmel\key
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General Information
Symbol
Dmel\key
Species
D. melanogaster
Name
kenny
Annotation Symbol
CG16910
Feature Type
protein_coding_gene
FlyBase ID
FBgn0041205
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
kenny (key) encodes a scaffold protein that is a component of the IKK (IκB Kinase) complex, which participates in the activation of the transcription factor Rel in the Imd pathway. This pathway regulates the antibacterial response and other less characterized cellular processes. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

IKKγ, DmIKKγ, IKK-γ, IKK

Key Links
Genomic Location
Cytogenetic map
60E1-60E1
Sequence location
Recombination map
2-107
RefSeq locus
NT_033778 REGION:24785514..24787411
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q9VEZ5
(Silverman et al., 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables K63-linked polyubiquitin modification-dependent protein binding
inferred from biological aspect of ancestor with PANTHER:PTN001268347
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR034735
(InterPro Project Members, 2004-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in defense response to Gram-negative bacterium
inferred from mutant phenotype
(Wang et al., 2012, Berkey et al., 2009, Gobert et al., 2003, Gottar et al., 2002, Rutschmann et al., 2002)
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
involved_in defense response to virus
inferred from mutant phenotype
(Costa et al., 2009)
involved_in immune response
inferred from mutant phenotype
(Ryu et al., 2006)
involved_in negative regulation of stem cell proliferation
inferred from mutant phenotype
(Wang et al., 2013)
involved_in peptidoglycan recognition protein signaling pathway
inferred from mutant phenotype
(Paquette et al., 2010, Ertürk-Hasdemir et al., 2009, Valanne et al., 2007, Boutros et al., 2002, Gottar et al., 2002, Naitza et al., 2002)
inferred from direct assay
(Kietz et al., 2022)
involved_in positive regulation of antibacterial peptide biosynthetic process
inferred from mutant phenotype
(Rutschmann et al., 2000)
involved_in positive regulation of defense response to virus by host
inferred from mutant phenotype
(Avadhanula et al., 2009)
involved_in positive regulation of innate immune response
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Bonnay et al., 2014)
involved_in protein catabolic process
inferred from direct assay
(Silverman et al., 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of canonical NF-kappaB signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN001268347
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Silverman et al., 2000)
located_in nucleus
inferred from direct assay
(Silverman et al., 2000)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001268347
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001268347
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
kenny (key) encodes a scaffold protein that is a component of the IKK (IκB Kinase) complex, which participates in the activation of the transcription factor Rel in the Imd pathway. This pathway regulates the antibacterial response and other less characterized cellular processes. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
Imd Signaling Pathway Core Components -
The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
Protein Function (UniProtKB)
Essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for NF-kappa-B (Rel) activation. Required for antibacterial immune response.
(UniProt, Q9GYV5)
Summary (Interactive Fly)

IkappaB kinase, respectively IKK regulatory and catalytic subunits - induction of antimicrobial peptide genes

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\key for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9GYV5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
key-RA
FBtr0072428
NM_079132
1415
387
key-RB
FBtr0305672
NM_001259574
1421
389
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
key-PA
FBpp0072333
43.9
387
5.37
Q9GYV5
NP_523856
AAF47273
key-PB
FBpp0296952
44.1
389
5.53
A0A0B4K885
NP_001246503
AFH08256
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with IKKbeta to form the I-kappa-B kinase complex.

(UniProt, Q9GYV5)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\key using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.14

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult Malpighian tubule
(McGettigan et al., 2005)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Silverman et al., 2000)
located_in nucleus
inferred from direct assay
(Silverman et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\key in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of key
Transgenic constructs containing regulatory region of key
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Dll-MP
(Rutschmann et al., 2000)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (4)
Hsap\OPTN
3 of 14
Yes
Yes
3  
Hsap\IKBKG
2 of 14
No
Yes
1  
Hsap\ODF2
1 of 14
No
No
Hsap\ODF2L
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Optn
3 of 14
Yes
Yes
Rnor\Ikbkg
2 of 14
No
Yes
Rnor\Lama2
1 of 14
No
No
Rnor\Odf2l
1 of 14
No
No
Rnor\Odf2
1 of 14
No
No
Mus musculus (laboratory mouse) (5)
Mmus\Optn
3 of 14
Yes
Yes
Mmus\Ikbkg
2 of 14
No
Yes
Mmus\Eea1
1 of 14
No
No
Mmus\Odf2l
1 of 14
No
No
Mmus\Odf2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\ikbkg
3 of 13
Yes
Yes
Xtro\optn
3 of 13
Yes
Yes
Xtro\odf2
1 of 13
No
No
Danio rerio (Zebrafish) (5)
Drer\optn
4 of 14
Yes
Yes
Drer\ikbkg
3 of 14
No
Yes
Drer\odf2a
1 of 14
No
No
Drer\odf2b
1 of 14
No
No
Drer\synm
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP005933
9 of 12
Yes
Yes
Agam\AgaP_AGAP005859
2 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:key. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Human Ortholog
    Disease
    Evidence
    References
    OPTN; optineurin
    model of  primary open angle glaucoma
    IEA
    (FlyBase, 2019-)
    model of  amyotrophic lateral sclerosis type 12
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    OPTN; optineurin
    3 of 14
    602432
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Diedel
    suppressible
    key
    (Lamiable et al., 2016)
    Lam
    suppressible
    key
    (Chen et al., 2014)
    norpA
    suppressible
    key
    (Chinchore et al., 2012)
    PGRP-LF
    enhanceable
    key
    (Maillet et al., 2008)
    PGRP-LF
    suppressible
    key
    (Maillet et al., 2008)
    External Data
    Subunit Structure (UniProtKB)
    Interacts with IKKbeta to form the I-kappa-B kinase complex.
    (UniProt, Q9GYV5 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Imd Signaling Pathway Core Components -
    The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
    Metabolic Pathways
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-107
    Cytogenetic map
    60E1-60E1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    60E1-60E1
    Limits computationally determined from genome sequence between P{lacW}Mmp1k04809 and P{EP}Reg-5EP1065
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    60E-60E
    (Silverman, 2000.3.6, Zhou, 2000.8.8)
    Experimentally Determined Recombination Data
    Location

    2-107

    (FlyBase, 2016)

    2-111.4

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (12)
    Genomic Clones (17)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (29)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        key is necessary to provide immunity to reactive oxygen species-resistant pathogens.

        (Ryu et al., 2006)

        dsRNA made from templates generated with primers directed against this gene stops cleavage of the Rel protein product in mbn-2 and S2 cells.

        (Kleino et al., 2005)

        Mutant flies are highly susceptible to bacterial infections. The inducibility of Dpt but not Drs is markedly reduced in mutant flies challenged with a mixture of E.coli and M.luteus.

        (Rutschmann et al., 2000)

        Identification: as a protein that interacts with ird5 in a yeast two-hybrid screen.

        (Silverman et al., 2000)

        key is required for the activation of the antibacterial immune response genes.

        (Silverman et al., 2000)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: IKKγ CG16910

        (FlyBase, 1996-)
        Additional comments

        Source for merge of IKKγ CG16910 was sequence comparison ( date:000915 ).

        (FlyBase, 1996-)
        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (21)
        Reported As
        Symbol Synonym
        CG16910
        (Douglas et al., 2011, Ni et al., 2011.7.19, Zheng et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Irving et al., 2001)
        DmIKK-γ
        (Zhou et al., 2005)
        DmIKKγ
        (Fukuyama et al., 2013, Silverman et al., 2003, Zhou et al., 2002, Silverman and Maniatis, 2001, Silverman and Maniatis, 2001, Vidal et al., 2001, Zhou et al., 2001, Silverman et al., 2000)
        Dmikkγ
        (Lemaitre, 2000.12.20)
        IKK
        (Maillet et al., 2008, Bischoff et al., 2006, Bischoff et al., 2004)
        IKK-γ
        (Schneider and Imler, 2021, Sciambra and Chtarbanova, 2021, Keebaugh and Schlenke, 2014, Kingsolver et al., 2013, Paquette et al., 2010, Akira et al., 2006, Leclerc and Reichhart, 2004, Hoffmann, 2003)
        IKKγ
        (Leone et al., 2008)
        IKKG
        (Fukuyama et al., 2013)
        IKKg
        (Waterhouse et al., 2007)
        IKKγ
        (Benoit et al., 2022, Salem Wehbe et al., 2021, Kounatidis and Chtarbanova, 2018, Mussabekova et al., 2017, Imler, 2014, Buchon et al., 2013, Ertürk-Hasdemir et al., 2009, Obbard et al., 2009, Waterhouse et al., 2007, Bischoff et al., 2006, Brennan and Anderson, 2004, Sun et al., 2002, Kimbrell and Beutler, 2001, Khush and Lemaitre, 2000, Khush and Lemaitre, 2000, Silverman, 2000.3.6, Silverman et al., 2000)
        Ikkγβ
        (Xu and Cherry, 2014)
        KEY
        (Fukuyama et al., 2013, Cronin et al., 2009)
        Kenny
        (Kietz and Meinander, 2023, Cammarata-Mouchtouris et al., 2022, Rahman et al., 2022, Eleftherianos and Castillo, 2012, Igboin et al., 2012, Leclerc and Reichhart, 2004, Irving et al., 2001, Wasserman, 2000)
        Key
        (Lu and Chtarbanova, 2022, Michki et al., 2021, Tang et al., 2021, Vandehoef et al., 2020, Molaei et al., 2019, Lee et al., 2017, Tusco et al., 2017, Kanoh et al., 2015, Imler, 2014, Kleino and Silverman, 2014, Myllymäki et al., 2014, Zheng et al., 2011, Aymeric et al., 2010, Goto et al., 2010, Bond and Foley, 2009, Bergeret et al., 2008, Lesch et al., 2007, Gesellchen et al., 2005, McGettigan et al., 2005)
        dIKK
        (Mushegian and Medzhitov, 2001)
        dIKK-γ
        (Govind and Nehm, 2004)
        dIKKγ
        (Goto et al., 2018)
        dmIKKγ
        (Khush et al., 2002)
        kenny
        (Koltun et al., 2017, Louie et al., 2016, Zhou et al., 2008)
        key
        (Hédelin et al., 2024, Chen et al., 2023, Pavlidaki et al., 2022, Tsapras and Nezis, 2022, Wu et al., 2022, Yu et al., 2022, Baek et al., 2021, Buhlman et al., 2021, Biwot et al., 2020, Krautz et al., 2020, Robinson et al., 2020, Gene Disruption Project members, 2018-, Goto et al., 2018, Kamareddine et al., 2018, Zhang et al., 2018, Christesen et al., 2017, Transgenic RNAi Project members, 2017-, Tusco et al., 2017, Lamiable et al., 2016, Lee et al., 2016, Verma and Tapadia, 2015, Bonnay et al., 2014, Chen et al., 2014, Sopko et al., 2014, Bonnay et al., 2013, Katzenberger et al., 2013, Kwon et al., 2013, Nelson et al., 2013, Quintin et al., 2013, Wang et al., 2013, Chinchore et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Wang et al., 2012, Bou Aoun et al., 2011, Douglas et al., 2011, Glittenberg et al., 2011, Igboin et al., 2011, Karpac et al., 2011, Limmer et al., 2011, Nehme et al., 2011, Ragab et al., 2011, Valanne et al., 2011, Zheng et al., 2011, Hill-Burns and Clark, 2010, Radyuk et al., 2010, Avadhanula et al., 2009, Berkey et al., 2009, Brown et al., 2009, Costa et al., 2009, Maillet et al., 2008, Tresch and Markowetz, 2008, Busse et al., 2007, Nehme et al., 2007, Sackton et al., 2007, Valanne et al., 2007, Delaney et al., 2006, Gottar et al., 2006, Kaneko et al., 2006, Kim et al., 2006, Leclerc et al., 2006, Mulinari et al., 2006, Ryu et al., 2006, Castillejo-Lopez and Häcker, 2005, Dionne et al., 2003, Gobert et al., 2003, Leulier et al., 2003, Ligoxygakis et al., 2002, Rutschmann et al., 2002, Tauszig-Delamasure et al., 2002)
        Name Synonyms
        Kenney
        (Fukuyama et al., 2013)
        Kenny
        (Khan et al., 2023, Benoit et al., 2022, Cheung et al., 2022, Harnish et al., 2021, Rosendo Machado et al., 2021, Zhu et al., 2021, Arora and Ligoxygakis, 2020, Gohel et al., 2020, Aalto et al., 2019, Tusco et al., 2017, Xiong et al., 2016, Shirinian et al., 2015, Bonnay et al., 2014, Garcia et al., 2012, Vandenabeele and Bertrand, 2012, Buchon et al., 2009, Bond et al., 2008, Glittenberg and Ligoxygakis, 2007, Kuranaga and Miura, 2007, Tsichritzis et al., 2007, Gesellchen et al., 2005)
        kenny
        (Williams et al., 2023, André et al., 2020, Blount et al., 2020, Jacomin et al., 2020, Meltzer et al., 2019, Palmer et al., 2018, Yadav et al., 2017, Lee et al., 2016, Shirinian et al., 2015, Bonnay et al., 2014, Merkling and van Rij, 2013, Igboin et al., 2011, Limmer et al., 2011, Zheng et al., 2011, Radyuk et al., 2010, Valanne et al., 2010, Brown et al., 2009, Costa et al., 2009, Zsindely et al., 2009, Ferrandon et al., 2007, Nehme et al., 2007, Williams et al., 2007, Gottar et al., 2006, Kim et al., 2006, Leclerc et al., 2006, Filipe et al., 2005, Leulier et al., 2003, Ligoxygakis et al., 2002, Tauszig-Delamasure et al., 2002, Rutschmann et al., 2000)
        Secondary FlyBase IDs
        • FBgn0035066
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 61 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        References (234)